公开(公告)号：US4916214A

公开(公告)日：1990-04-10

申请号：US254082

申请日：1988-10-06

申请人： Kwok W. Chiu ,  James D. Kelly ,  Ian A. Latham ,  David V. Griffiths ,  Peter G. Edwards

发明人： Kwok W. Chiu ,  James D. Kelly ,  Ian A. Latham ,  David V. Griffiths ,  Peter G. Edwards

IPC分类号： A61K51/00 ,  A61K51/04 ,  C07F9/50 ,  C07F9/655 ,  C07F9/68 ,  C07F9/72 ,  C07F13/00

CPC分类号： C07F9/6552 ,  A61K51/04 ,  C07F13/005 ,  C07F9/5027 ,  C07F9/723 ,  A61K2123/00

摘要： The invention concerns cationic complexes of Technetium-99m with bidentate ligands (L), including complexes having the formulae [Tc(NO) X L.sub.2 ].sup.+ and [Tc L.sub.3 ].sup.+, which are of interest as heart imaging agents. The ligands are characterized by having the formula Y.sub.2 QZQY.sub.2, where each Q is phosphorus or arsenic, Z is a 2 or 3 carbon atom linking group, and at least one of the groups Y and Z includes at least one --COC--ether group.

公开(公告)号：US5344639A

公开(公告)日：1994-09-06

申请号：US719715

申请日：1991-06-26

申请人： Kwok W. Chiu ,  Wassif Hussain ,  John R. Thornback

发明人： Kwok W. Chiu ,  Wassif Hussain ,  John R. Thornback

IPC分类号： A61K49/00 ,  C07K5/02 ,  C07K5/06 ,  A61B5/055 ,  C07C229/00

CPC分类号： C07K5/022 ,  Y10T436/24

摘要： The present invention relates to a contrast agent for NMR imaging constituted by a complex between a chelating agent and paramagnetic metal cations, wherein said complex corresponds to the formula I: ##STR1## or a physiologically acceptable salt of this complex, in which formula: n and n' are whole numbers from 1 to 4R.sub.1 -R.sub.7 are selected from among H, a halogen, alkyl, alkoxy, aryl, alkenyl, and cycloalkyl groups; with the alkyl groups being optionally substituted by halogen, alkoxy, alkyl, nitrile, nitro or amino; >C(R.sub.6, R.sub.7) can in addition represent >C=O;the three substituents Y are identical or different and represent H or an ionic equivalent of a divalent or trivalent paramagnetic metal cation or of a physiologically acceptable cation derived from an inorganic or organic base,with the condition that at least two of the substituents Y represent ionic equivalents of paramagnetic metal cations.

摘要翻译： 本发明涉及由螯合剂和顺磁性金属阳离子之间的络合物构成的NMR成像造影剂，其中所述复合物对应于该络合物的式I：t，式中n和n'为 1至4个R 1 -R 7选自H，卤素，烷基，烷氧基，芳基，烯基和环烷基; 烷基，腈，硝基或氨基任选被烷基取代; > C（R 6，R 7）可以另外表示> C = O; 三个取代基Y相同或不同，表示二价或三价顺磁金属阳离子或衍生自无机或有机碱的生理学上可接受的阳离子的H或离子当量，条件是至少两个取代基Y表示离子 顺磁金属阳离子的当量。

公开(公告)号：US5312904A

公开(公告)日：1994-05-17

申请号：US879098

申请日：1992-05-04

申请人： James D. Kelly ,  Kwok W. Chiu ,  David V. Griffiths ,  Jonathan R. Dilworth

发明人： James D. Kelly ,  Kwok W. Chiu ,  David V. Griffiths ,  Jonathan R. Dilworth

IPC分类号： A61K51/00 ,  A61K51/04 ,  C07F9/50 ,  C07F9/72 ,  C07F9/74 ,  C07F13/00 ,  A61K49/02

CPC分类号： C07F13/005 ,  A61K51/0478 ,  A61K2123/00

摘要： Tridentate mono-anionic ligands have the structureX-A-Y-Q-Zwhere each of X and Y is independently P, As or N,Z is phenol, thiophenol or thiol, andA and Q are hydrocarbon linking groups.The ligands from cationic complexes with Technetium-99m, e.g. [Tc.sup.III K.sub.2 ].sup.+ where K is the ligand, having useful imaging properties.

摘要翻译： 三齿单阴离子配体具有结构X-A-Y-Q-Z，其中X和Y各自独立地为P，As或N，Z为苯酚，苯硫酚或硫醇，A和Q为烃连接基团。 来自与锝-99m的阳离子络合物的配体，例如 [TcIIIK2] +其中K是配体，具有有用的成像性质。

公开(公告)号：US5045302A

公开(公告)日：1991-09-03

申请号：US329639

申请日：1989-03-28

申请人： James D. Kelly ,  Kwok W. Chiu ,  Ian A. Latham

发明人： James D. Kelly ,  Kwok W. Chiu ,  Ian A. Latham

IPC分类号： A61K51/00 ,  A61K51/04 ,  C07F9/50 ,  C07F9/655 ,  C07F9/70 ,  C07F13/00

CPC分类号： A61K51/04 ,  C07F13/005 ,  C07F9/5027 ,  C07F9/655 ,  A61K2123/00

摘要： This invention concerns novel bidentate ligands L having two phosphorus or arsenic atoms. Cationic complexes of the ligands with Technetium-99m, e.g. having the formula [TcO.sub.2 L.sub.2 ].sup.+, are useful for body imaging, particularly myocardial imaging. The ligands have the general formulaY.sub.2 QZQY.sub.2where Q is phosphorus orZ is a --CC-- or --CCC-- or --COC-- groups,the four groups Y are all C1-C8 saturated hydrocarbon or fluorohydrocarbon with 1-3 ether oxygen atoms.