公开(公告)号：US20110009636A1

公开(公告)日：2011-01-13

申请号：US12865234

申请日：2009-02-12

Applicant: Chun-Ho Lee ,  Ja-Heouk Khoo ,  Kyoung-Chan Kwon ,  Hyun Ju

Inventor： Chun-Ho Lee ,  Ja-Heouk Khoo ,  Kyoung-Chan Kwon ,  Hyun Ju

IPC: C07D401/04 ,  C07C69/612 ,  C07C309/70 ,  C07C309/77 ,  C07C303/28 ,  C07C67/31 ,  C07D401/14

CPC classification number: C07D401/04 ,  C07C67/31 ,  C07C67/46 ,  C07C69/612

Abstract: The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2′-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.

Abstract translation: 本发明涉及以更简化的方式制备显示抗组胺活性的2-甲基-2'-苯基丙酸衍生物的方法，中间体化合物及其制备方法。 根据本发明，可以以工业规模高产率和纯度制备药学上可用的2-甲基-2'-苯基丙酸衍生物。

公开(公告)号：US08367704B2

公开(公告)日：2013-02-05

申请号：US12865234

申请日：2009-02-12

Applicant: Chun-Ho Lee ,  Ja-Heouk Khoo ,  Kyoung-Chan Kwon ,  Hyun Ju

Inventor： Chun-Ho Lee ,  Ja-Heouk Khoo ,  Kyoung-Chan Kwon ,  Hyun Ju

IPC: A61K31/445 ,  C07D401/04 ,  C07D413/14

CPC classification number: C07D401/04 ,  C07C67/31 ,  C07C67/46 ,  C07C69/612

Abstract: The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2′-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.

Abstract translation: 本发明涉及以更简化的方式制备显示抗组胺活性的2-甲基-2'-苯基丙酸衍生物的方法，中间体化合物及其制备方法。 根据本发明，可以以工业规模高产率和纯度制备药学上可用的2-甲基-2'-苯基丙酸衍生物。

公开(公告)号：US06689913B2

公开(公告)日：2004-02-10

申请号：US10330927

申请日：2002-12-27

Applicant: Tai-Au Lee ,  Kyu-Jung Wang ,  Hong-Bae Kim ,  Kyoung-Chan Kwon ,  Chang-Hoe Ku

Inventor： Tai-Au Lee ,  Kyu-Jung Wang ,  Hong-Bae Kim ,  Kyoung-Chan Kwon ,  Chang-Hoe Ku

IPC: C07C20900

CPC classification number: C07C209/28 ,  C07C211/30

Abstract: Provided is a process for preparing terbinafine or its HCl salt comprising: reacting a furan derivative with a base to form a second compound; performing a reductive alkylation of the second compound obtained in the step with N-methyl-1-naphthalenemethylamine or its HCl salt to form a third compound; and purifying the third compound.

Abstract translation: 提供了一种制备特比萘芬或其HCl盐的方法，包括：使呋喃衍生物与碱反应形成第二化合物; 用N-甲基-1-萘甲胺或其HCl盐进行步骤中获得的第二化合物的还原烷基化，形成第三化合物; 并纯化第三化合物。