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    NON-AQUEOUS ELECTROLYTIC SOLUTION, ELECTROCHEMICAL ELEMENT USING SAME, AND ALKYNYL COMPOUND USED THEREFOR
    3.
    发明申请
    NON-AQUEOUS ELECTROLYTIC SOLUTION, ELECTROCHEMICAL ELEMENT USING SAME, AND ALKYNYL COMPOUND USED THEREFOR 有权
    非水溶性电解液，电化学元素及其使用的烷基化合物

    公开(公告)号：US20120301797A1

    公开(公告)日：2012-11-29

    申请号：US13576182

    申请日：2011-02-02

    Applicant: Koji Abe ,  Kazuhiro Miyoshi ,  Masahide Kondo

    Inventor： Koji Abe ,  Kazuhiro Miyoshi ,  Masahide Kondo

    IPC: H01M10/056 ,  C07C309/70 ,  C07C309/68 ,  C07C309/67

    CPC classification number: H01M10/0567 ,  C07C309/67 ,  C07F9/113 ,  C07F9/327 ,  H01M10/052 ,  H01M2300/0025 ,  Y02E60/122 ,  Y02T10/7011

    Abstract: The present invention provides an excellent nonaqueous electrolytic solution capable of improving low-temperature and high-temperature cycle properties and load characteristics after high-temperature charging storage, an electrochemical element using it, and an alkynyl compound used for it.The nonaqueous electrolytic solution of the present invention comprises containing at least one alkynyl compound represented by the following general formula (I) in an amount of from 0.01 to 10% by mass in the nonaqueous electrolytic solution. R1(O)n—X1—R2  (I) (In the formula, X1 represents a group —C(═O)—, a group —C(═O)—C(═O)—, a group —S(═O)2—, a group —P(═O) (—R3)—, or a group —X2—S(═O)2O—. R1 represents an alkenyl group, a formyl group, an alkyl group, an acyl group, an arylcarbonyl, an alkanesulfonyl group, an alkynyloxysulfonyl group, an arylsulfonyl group, a dialkylphosphoryl group, an alkyl(alkoxy)phosphoryl group, or a dialkoxyphosphoryl group; R2 represents an alkynyl group or an alkynyloxy group; R3 represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkoxy group, an alkenyloxy group, an alkynyloxy group, or an aryloxy group; n indicates 0 or 1.

    Abstract translation: 本发明提供一种能够提高高温充电保存后的低温高温循环性能和负载特性的优异的非水电解液，使用它的电化学元件和用于其的炔基化合物。 本发明的非水电解液在非水电解液中含有0.01〜10质量％的由通式（I）表示的至少一种炔基化合物。 R 1（O）n -X 1 -R 2（I）（式中，X1表示-C（= O） - 基，-C（= O）-C（= O） - 基，-S（ = O）2-，基团-P（= O）（-R 3） - 或基团-X 2 -S（= O）2 O-，R 1表示链烯基，甲酰基，烷基，酰基 基团，芳基羰基，烷磺酰基，炔氧基磺酰基，芳基磺酰基，二烷基磷酰基，烷基（烷氧基）磷酰基或二烷氧基磷酰基; R2表示炔基或炔氧基; R3表示烷基， 烯基，炔基，芳基，烷氧基，烯氧基，炔氧基或芳氧基; n表示0或1。

    2-phenylpropionic acid derivatives and pharmaceutical compositions containing them
    4.
    发明申请
    2-phenylpropionic acid derivatives and pharmaceutical compositions containing them 有权
    2-苯基丙酸衍生物和含有它们的药物组合物

    公开(公告)号：US20090203740A1

    公开(公告)日：2009-08-13

    申请号：US10592572

    申请日：2005-03-21

    Applicant: Marcello Allegretti ,  Maria Candida Cesta ,  Riccardo Bertini ,  Marco Mosca ,  Francesco Colotta

    Inventor： Marcello Allegretti ,  Maria Candida Cesta ,  Riccardo Bertini ,  Marco Mosca ,  Francesco Colotta

    IPC: A61K31/4453 ,  C07C309/70 ,  A61K31/255 ,  C07D211/06

    CPC classification number: C07C309/65 ,  C07C2601/08 ,  C07D295/13

    Abstract: 4-(trifluoromethanesulfonyloxyphenyl)propionic acid derivatives and pharmaceutical composition containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, these metabolites are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

    Abstract translation: 4-（三氟甲磺酰氧基苯基）丙酸衍生物和含有这些化合物的药物组合物可用于抑制由白细胞介素-8（IL-8）与CXCR1和CXCR2膜受体相互作用诱导的嗜中性粒细胞（PMN白细胞）的趋化活化。 所述化合物用于预防和治疗由所述活化引起的病理学。 值得注意的是，这些代谢物没有环加氧酶抑制活性，并且特别可用于治疗嗜中性粒细胞依赖性病理学如牛皮癣，溃疡性结肠炎，黑素瘤，慢性阻塞性肺病（COPD），大疱性类天疱疮，类风湿性关节炎，特发性纤维化， 在预防和治疗由缺血和再灌注引起的损伤中的肾小球肾炎。

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