公开(公告)号：US07259276B2

公开(公告)日：2007-08-21

申请号：US10608466

申请日：2003-06-27

申请人： László Vertesy ,  Michael Kurz ,  Joachim Wink

发明人： László Vertesy ,  Michael Kurz ,  Joachim Wink

IPC分类号： C07C59/00 ,  C07C323/02 ,  C07C229/00 ,  C07C69/76

CPC分类号： C12R1/01 ,  C07C57/42 ,  C07C59/48 ,  C12P7/42 ,  C12P7/44 ,  C12P7/62

摘要： The present invention relates to novel compounds, termed serpentemycins, of the formula (I) in which Y, R, R2, R3, R4, X, X2, X3, n, m and o are as defined in the specification, which are formed by the microorganism Actinomycetales sp. DSM 14865 during its fermentation, to chemical derivatives of the serpentemycins, to a process for preparing them, and to their use as pharmaceuticals, in particular for the treatment and prophylaxis of infectious bacterial diseases.

摘要翻译： 本发明涉及式（I）的新的化合物，称为蛇霉素，其中Y，R，R 2，R 3，R 4， X，X 2，X 3，n，m和o如本说明书中所定义，由微生物放线菌（Spinomycetales sp。）形成。 DSM 14865在其发酵过程中，涉及蛇血霉素的化学衍生物，其制备方法及其用作药物，特别是用于治疗和预防感染性细菌性疾病。

公开(公告)号：US06194383B1

公开(公告)日：2001-02-27

申请号：US08811843

申请日：1997-03-05

申请人： Peter Hammann ,  Johannes Meiwes ,  Gerhard Seibert ,  László Vertesy ,  Joachim Wink ,  Astrid Markus

发明人： Peter Hammann ,  Johannes Meiwes ,  Gerhard Seibert ,  László Vertesy ,  Joachim Wink ,  Astrid Markus

IPC分类号： A61K3800

CPC分类号： C07K7/60 ,  A61K38/00 ,  Y10S435/827

摘要： The invention relates to lipopeptides with very homologous amino-acid sequences but different fatty acid residues (lipid portion) which are synthesized by Actinoplanes sp. during fermentation and are released into the culture medium, to a process for isolating the lipopeptides from the culture medium and purifying them, to the use of the lipopeptides as pharmacologically active substances, in particular against Gram-positive bacteria, and to Actinoplanes sp. DSM 7358 for producing the abovementioned lipopeptides.

摘要翻译： 本发明涉及具有非常同源的氨基酸序列但不同脂肪酸残基（脂质部分）的脂肽，其由Actinoplanes sp。 在发酵过程中释放到培养基中，从分离来自培养基中的脂肽并纯化它们的方法，使用脂肽作为药理活性物质，特别是抗革兰氏阳性细菌，以及使用Actinoplanes sp。 DSM 7358用于生产上述脂肽。