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公开(公告)号：US20090062377A1
公开(公告)日：2009-03-05
申请号：US12264197
申请日：2008-11-03
申请人： Liang-Chuan Steve Wang , James William Paxton , Lai-Ming Ching , Bruce Charles Baguley , Philip Kestell
发明人： Liang-Chuan Steve Wang , James William Paxton , Lai-Ming Ching , Bruce Charles Baguley , Philip Kestell
IPC分类号： A61K31/352 , A61P35/04
CPC分类号： A61K45/06 , A61K31/352 , A61K2300/00
摘要： The present invention relates to synergistic combinations of the compounds of formula I such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and NSAIDs, in particular diclofenac, which have anti-tumour activity. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing said combinations.
摘要翻译： 本发明涉及式I化合物的协同组合，例如呫吨酮乙酸类化合物如5,6-二甲基呫吨酮-4-乙酸（DMXAA）和NSAIDs，特别是双氯芬酸，其具有抗肿瘤活性 。 更具体地，本发明涉及这样的组合在治疗癌症中的用途以及含有所述组合的药物组合物。
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公开(公告)号：US20170224701A1
公开(公告)日：2017-08-10
申请号：US15503210
申请日：2015-08-12
申请人： Brian Desmond Palmer , Lai Ming Ching , Swarnalatha Akuratiya Gamage , AUCKLAND UNISERVICES LIMITED
IPC分类号： A61K31/5377 , A61K31/444 , A61K31/519 , A61K31/437 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/423 , A61K31/437 , A61K31/444 , A61K31/4745 , A61K31/519 , A61K45/06 , C07D498/04 , A61K2300/00
摘要： Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
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公开(公告)号：US07585893B2
公开(公告)日：2009-09-08
申请号：US11116798
申请日：2005-04-28
IPC分类号： A61K31/35
CPC分类号： A61K31/352 , A61K9/0053
摘要： The present invention relates to the use of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) for the treatment of cancer, wherein the compounds are administered gastrointestinally, preferably orally. More particularly, the invention is concerned with the use of such compounds, wherein the compound is delivered to the site of action in the patient to be treated in two or more doses.
摘要翻译： 本发明涉及化合物如呫吨酮乙酸类化合物如5,6-二甲基呫吨酮-4-乙酸（DMXAA）用于治疗癌症的用途，其中所述化合物是胃肠道给药，优选口服施用的。 更具体地说，本发明涉及这种化合物的用途，其中化合物以两种或更多种剂量递送至待治疗患者的作用部位。
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公开(公告)号：US07510830B2
公开(公告)日：2009-03-31
申请号：US10341736
申请日：2003-01-14
IPC分类号： A61K39/395 , A61K38/00
CPC分类号： A61K31/352 , A61K31/222 , A61K31/739 , A61K38/2006 , A61K45/06 , A61K2300/00
摘要： Methods and compositions are provided for treating cancer, the methods including the step administering, either sequentially or simultaneously, (i) a compound of the xanthenone acetic acid group of compounds, and (ii) at least one compound selected from compounds which modulate TNF production and compounds which act on biochemical pathways leading to TNF synthesis. Compositions include a combination of (i) and (ii) above, together with acceptable pharmaceutical carriers and/or vehicles.
摘要翻译： 提供了用于治疗癌症的方法和组合物，所述方法包括顺序或同时地步骤（i）化合物的呫吨酮乙酸基化合物和（ii）至少一种选自调节TNF产生的化合物的化合物 和作用于导致TNF合成的生物化学途径的化合物。 组合物包括上述（i）和（ii）的组合，以及可接受的药物载体和/或载体。
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公开(公告)号：US20080167272A1
公开(公告)日：2008-07-10
申请号：US11454420
申请日：2006-06-16
申请人： Lai-Ming Ching , Brian D. Palmer
发明人： Lai-Ming Ching , Brian D. Palmer
IPC分类号： A61K31/661 , A61K31/4523 , A61P35/00
CPC分类号： A61K31/4523 , A61K31/661
摘要： The present invention concerns certain hydrolytic thalidomide metabolites, combinations thereof with other anti-neoplastic compounds and their use in the treatment of solid tumours.
摘要翻译： 本发明涉及某些水解沙利度胺代谢物，其与其它抗肿瘤化合物的组合及其在治疗实体瘤中的用途。
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公开(公告)号：US20060009505A1
公开(公告)日：2006-01-12
申请号：US11116798
申请日：2005-04-28
申请人： Bruce Baguley , Lai-Ming Ching , Philip Kestell , Liangli Zhao
发明人： Bruce Baguley , Lai-Ming Ching , Philip Kestell , Liangli Zhao
IPC分类号： A61K31/4172
CPC分类号： A61K31/352 , A61K9/0053
摘要： The present invention relates to the use of compounds such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) for the treatment of cancer, wherein the compounds are administered gastrointestinally, preferably orally. More particularly, the invention is concerned with the use of such compounds, wherein the compound is delivered to the site of action in the patient to be treated in two or more doses.
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公开(公告)号：US20050131059A1
公开(公告)日：2005-06-16
申请号：US10946833
申请日：2004-09-22
IPC分类号： A61K45/00 , A61K31/192 , A61K31/196 , A61K31/341 , A61K31/352 , A61K31/353 , A61K31/60 , A61K31/635 , A61K45/06 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/352 , A61K2300/00
摘要： The present invention relates to synergistic combinations of the compounds of formula I such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and NSAIDs, in particular diclofenac, which have anti-tumour activity. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing said combinations.
摘要翻译： 本发明涉及式I化合物的协同组合，例如呫吨酮乙酸类化合物如5,6-二甲基呫吨酮-4-乙酸（DMXAA）和NSAIDs，特别是双氯芬酸，其具有抗肿瘤活性 。 更具体地，本发明涉及这样的组合在治疗癌症中的用途以及含有所述组合的药物组合物。
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公开(公告)号：US07462642B2
公开(公告)日：2008-12-09
申请号：US10946833
申请日：2004-09-22
申请人： Liang-Chuan Steve Wang , James William Paxton , Lai-Ming Ching , Bruce Charles Baguley , Philip Kestell
发明人： Liang-Chuan Steve Wang , James William Paxton , Lai-Ming Ching , Bruce Charles Baguley , Philip Kestell
IPC分类号： A61K31/35
CPC分类号： A61K45/06 , A61K31/352 , A61K2300/00
摘要： The present invention relates to synergistic combinations of the compounds of formula I such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and NSAIDs, in particular diclofenac, which have anti-tumor activity. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing said combinations.
摘要翻译： 本发明涉及式I化合物的协同组合，例如呫吨酮乙酸类化合物如5,6-二甲基呫吨酮-4-乙酸（DMXAA）和NSAIDs，特别是双氯芬酸，其具有抗肿瘤活性 。 更具体地，本发明涉及这样的组合在治疗癌症中的用途以及含有所述组合的药物组合物。
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公开(公告)号：US20070082937A1
公开(公告)日：2007-04-12
申请号：US10572304
申请日：2004-09-02
IPC分类号： A01N43/50
CPC分类号： A61K45/06 , A61K31/352 , A61K31/365 , A61K2300/00
摘要： The present invention relates to synergistic combinations of the compounds of formula (I) such as compounds of the xanthenone acetic acid class such as 5,6dimethylxanthenone-4-acetic acid (DMXAA) and a selective COX-2 inhibitor, in particular rofecoxib, which have anti-tumour activity. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical formulations containing said combinations.
摘要翻译： 本发明涉及式（I）化合物如呫吨酮乙酸类化合物如5,6-二甲基呫吨酮-4-乙酸（DMXAA）和选择性COX-2抑制剂，特别是罗非昔布的协同组合，其中 具有抗肿瘤活性。 更具体地，本发明涉及这样的组合在治疗癌症中的用途以及含有所述组合的药物制剂。
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