公开(公告)号：US20120184510A1

公开(公告)日：2012-07-19

申请号：US13006810

申请日：2011-01-14

申请人： Raymond W. Colburn ,  Scott L. Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark A. Youngman

发明人： Raymond W. Colburn ,  Scott L. Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark A. Youngman

IPC分类号： A61K31/675 ,  C07F9/28 ,  C07F9/02 ,  C07D333/50 ,  A61K31/67

CPC分类号： C07F9/655354 ,  C07F9/5728 ,  C07F9/6541 ,  C07F9/65517 ,  C07F9/655345 ,  C07F9/65586 ,  C07F9/6561

摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。

公开(公告)号：US08629281B2

公开(公告)日：2014-01-14

申请号：US13006810

申请日：2011-01-14

申请人： Raymond W. Colburn ,  Scott L. Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark A. Youngman

发明人： Raymond W. Colburn ,  Scott L. Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark A. Youngman

IPC分类号： C07F9/28

CPC分类号： C07F9/655354 ,  C07F9/5728 ,  C07F9/6541 ,  C07F9/65517 ,  C07F9/655345 ,  C07F9/65586 ,  C07F9/6561

摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。

公开(公告)号：US07897781B2

公开(公告)日：2011-03-01

申请号：US11746318

申请日：2007-05-09

申请人： Raymond W. Colburn ,  Scott L. Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark A. Youngman

发明人： Raymond W. Colburn ,  Scott L. Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark A. Youngman

IPC分类号： C07F9/28

CPC分类号： C07F9/655354 ,  C07F9/5728 ,  C07F9/65517 ,  C07F9/65586 ,  C07F9/6561

摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。

公开(公告)号：US20090247618A1

公开(公告)日：2009-10-01

申请号：US12055924

申请日：2008-03-26

申请人： Scott A. Ballentine ,  Laura Reany

发明人： Scott A. Ballentine ,  Laura Reany

IPC分类号： A61K31/357 ,  C07D319/16 ,  A61P25/08

CPC分类号： C07D319/20

摘要： The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.

摘要翻译： 本发明涉及用于治疗癫痫和相关疾病的苯并稠合杂芳基衍生物的制备方法。 本发明还涉及在苯并稠合杂芳基衍生物的合成中制备中间体的方法。

公开(公告)号：US20080027029A1

公开(公告)日：2008-01-31

申请号：US11746318

申请日：2007-05-09

申请人： Raymond Colburn ,  Scott Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark Youngman

发明人： Raymond Colburn ,  Scott Dax ,  Christopher Flores ,  Jay Matthews ,  Ning Qin ,  Laura Reany ,  Christopher Teleha ,  Mark Youngman

IPC分类号： A61K31/67 ,  A61K31/665 ,  A61K31/675 ,  A61P25/00 ,  A61P29/00 ,  A61P9/00 ,  A61P9/12 ,  C07D495/00 ,  C07F9/572 ,  C07F9/655 ,  C07F9/6553

CPC分类号： C07F9/655354 ,  C07F9/5728 ,  C07F9/65517 ,  C07F9/65586 ,  C07F9/6561

摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。