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    2,3-dihydro-4(1H)-pyridone derivatives , method for production thereof and pharmaceutical composition comprising the same
    2.
    发明申请
    2,3-dihydro-4(1H)-pyridone derivatives , method for production thereof and pharmaceutical composition comprising the same 审中-公开
    2,3-二氢-4（1H） - 吡啶酮衍生物，其制备方法和包含其的药物组合物

    公开(公告)号：US20060019995A1

    公开(公告)日：2006-01-26

    申请号：US10533784

    申请日：2003-11-04

    申请人： Sylvain Rault ,  Nicolas Leflemme ,  Patrick Dallemagne ,  Pierre Lestage ,  Brian Lockhart ,  Laurence Danober ,  Bruno Pfeiffer ,  Pierre Renard

    发明人： Sylvain Rault ,  Nicolas Leflemme ,  Patrick Dallemagne ,  Pierre Lestage ,  Brian Lockhart ,  Laurence Danober ,  Bruno Pfeiffer ,  Pierre Renard

    IPC分类号： A61K31/444 ,  A61K31/4436 ,  C07D409/02 ,  C07D401/02 ,  C07D211/72

    CPC分类号： C07D401/04 ,  C07D211/86 ,  C07D409/04

    摘要： A compound selected from those of formula (I): wherein: R1 represents hydrogen, aryl(C1-C6)alkyl, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, aryl(C1-C6)alkoxycarbonyl, or trifluoroacetyl, R2 represents hydrogen, linear or branched (C1-C6)alkyl, X represents oxygen or NOR3, R3 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more identical or different groups selected from hydroxy, amino and linear or branched (C1-C6)alkoxy, Ar represents aryl or heteroaryl, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cognitive disorders and which possess antalgic properties.

    摘要翻译： 选自式（I）的化合物的化合物：其中：R 1表示氢，芳基（C 1 -C 6 -C 6）烷基，直链 或支链（C 1 -C 6 -C 6）烷基，直链或支链（C 1 -C 6 -C 6）酰基（C 1 -C 6 -C 6） ，直链或支链（C 1 -C 6）烷氧基羰基，芳基（C 1 -C 6 -C 6）烷氧基羰基 ，或三氟乙酰基，R 2表示氢，直链或支链（C 1 -C 6 -C 6）烷基，X表示氧或NOR 3，R 3表示氢，任选被一个或多个相同的（C 1 -C 6）烷基取代的直链或支链（C 1 -C 6 -C 6）烷基， 或选自羟基，氨基和直链或支链（C 1 -C 6 -C 6）烷氧基的不同基团，Ar表示芳基或杂芳基，其异构体及其加成盐与 药学上可接受的酸或碱，以及含有该化合物的医药产品，其可用于治疗认知障碍并且具有止痛药 红酒

    Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
    4.
    发明申请
    Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them 有权
    苯并噻二嗪类化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US20100240635A1

    公开(公告)日：2010-09-23

    申请号：US12661598

    申请日：2010-03-19

    申请人： Alexis Cordi ,  Patrice Desos ,  Pierre Lestage ,  Laurence Danober

    发明人： Alexis Cordi ,  Patrice Desos ,  Pierre Lestage ,  Laurence Danober

    IPC分类号： A61K31/554 ,  C07D285/36 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/08 ,  A61P9/00 ,  A61P25/22 ,  A61P25/24

    CPC分类号： C07D285/36

    摘要： Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.

    摘要翻译： 式（I）的化合物：其中：R 1和R 2可以相同或不同，各自表示氢或卤素原子或烷基，烷氧基，烷硫基，酰基，烷氧基羰基，羧基，羟基，羟基烷基，氰基，硝基， 氨基，取代或未取代的氨基羰基，氨基磺酰基，烷基磺酰基氨基烷基，N-羟基 - 亚甲代酰胺或苄氧基，R3表示氢原子或烷基，环烷基或环烷基烷基，R4表示氢原子或取代或未取代的烷基含有 它们可用于治疗或预防由AMPA受体调节剂和/或NMDA受体拮抗剂治疗的病症。

    New benzothiazine and benzothiadiazine compounds
    5.
    发明申请
    New benzothiazine and benzothiadiazine compounds 失效
    新的苯并噻嗪和苯并噻二嗪化合物

    公开(公告)号：US20060128697A1

    公开(公告)日：2006-06-15

    申请号：US11297260

    申请日：2005-12-08

    申请人： Patrice Desos ,  Alexis Cordi ,  Pierre Lestage ,  Laurence Danober

    发明人： Patrice Desos ,  Alexis Cordi ,  Pierre Lestage ,  Laurence Danober

    IPC分类号： A61K31/549 ,  C07D498/02

    CPC分类号： C07D513/04

    摘要： The invention relates to compounds of formula (I): wherein R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A represents CR3R4 or NR3 wherein R3 and R4 are as defined in the description, Y represents an alkylene chain as described in the description, X represents NR5R6, S(O)nR7, OR8, C(O)R9, amidino or a heterocycle, their isomers, and addition salts thereof; and medicinal products containing the same which are useful in the prevention or treatment of diseases associated with AMPA flux.

    摘要翻译： 本发明涉及式（I）的化合物：其中R 1表示氢，烷基或环烷基，R 2表示氢，卤素或羟基，A表示CR 其中R 3和R 4如在说明书中所定义的那样，其中R 3和R 4都是如本文所定义的 ，Y表示如说明书中所述的亚烷基链，X表示NR 5 R 6，S（O）n R 7 C（O）R 9，脒基或杂环，它们的异构体及其加成盐; 以及含有该物质的药物，其可用于预防或治疗与AMPA通量相关的疾病。

    Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
    7.
    发明授权
    Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them 有权
    苯并噻二嗪类化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US08236790B2

    公开(公告)日：2012-08-07

    申请号：US12661598

    申请日：2010-03-19

    申请人： Alexis Cordi ,  Patrice Desos ,  Pierre Lestage ,  Laurence Danober

    发明人： Alexis Cordi ,  Patrice Desos ,  Pierre Lestage ,  Laurence Danober

    IPC分类号： C07D285/36 ,  A61K31/554

    CPC分类号： C07D285/36

    摘要： Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.

    摘要翻译： 式（I）的化合物：其中：R 1和R 2可以相同或不同，各自表示氢或卤素原子或烷基，烷氧基，烷硫基，酰基，烷氧基羰基，羧基，羟基，羟基烷基，氰基，硝基， 氨基，取代或未取代的氨基羰基，氨基磺酰基，烷基磺酰基氨基烷基，N-羟基 - 亚甲代酰胺或苄氧基，R3表示氢原子或烷基，环烷基或环烷基烷基，R4表示氢原子或取代或未取代的烷基含有 它们可用于治疗或预防由AMPA受体调节剂和/或NMDA受体拮抗剂治疗的病状。

    Thiadiazine derivatives and use thereof as positive AMPA receptor modulators
    8.
    发明授权
    Thiadiazine derivatives and use thereof as positive AMPA receptor modulators 失效
    噻二嗪衍生物及其作为阳性AMPA受体调节剂的用途

    公开(公告)号：US07476668B2

    公开(公告)日：2009-01-13

    申请号：US10555743

    申请日：2004-05-04

    申请人： Emmanuel Graindorge ,  Pierre Francotte ,  Stéphane Boverie ,  Pascal De Tullio ,  Bernard Pirotte ,  Pierre Lestage ,  Laurence Danober ,  Pierre Renard ,  Daniel-Henri Caignard

    发明人： Emmanuel Graindorge ,  Pierre Francotte ,  Stéphane Boverie ,  Pascal De Tullio ,  Bernard Pirotte ,  Pierre Lestage ,  Laurence Danober ,  Pierre Renard ,  Daniel-Henri Caignard

    IPC分类号： C07D513/04 ,  A61K31/542

    CPC分类号： C07D513/04

    摘要： Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR′ and SO2NHR′ wherein R′ represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.

    摘要翻译： 式（I）的化合物：其中：A表示噻吩基，呋喃基，吡咯基，氧硫杂环戊烷，噻唑，异噻唑，恶唑或咪唑，其中：=“3.13mm”wi =“6.35mm” file =“US07476668-20090113-P00001.TIF”alt =“custom character”img-content =“character”img-format =“tif”/>表示单键或双键，R1表示氢，直链或支链（ 任选被一个或多个选自卤素或（C 1 -C 6）烷氧基 - （C 1 -C 6）烷基的基团取代的C 1 -C 6烷基，R 2表示氢或任选被一个或多个（C 1 -C 6）烷氧基取代的直链或支链 卤素，R3表示氢或选自直链或支链（C1-C6）烷基，CONHR'和SO2NHR'的基团，其中R'表示直链或支链（C1-C6）烷基，其对映异构体和非对映异构体，以及其加成盐与 药学上可接受的酸或碱。 含有该药物的药物，可用作AMPA抑制剂。

    Fluorinated benzothiadiazine compounds
    9.
    发明授权
    Fluorinated benzothiadiazine compounds 失效
    氟化苯并噻二嗪化合物

    公开(公告)号：US07268129B2

    公开(公告)日：2007-09-11

    申请号：US11041495

    申请日：2005-01-24

    申请人： Pierre Francotte ,  Pierre Fraikin ,  Pascal De Tullio ,  Bernard Pirotte ,  Pierre Lestage ,  Laurence Danober ,  Daniel-Henri Caignard ,  Pierre Renard

    发明人： Pierre Francotte ,  Pierre Fraikin ,  Pascal De Tullio ,  Bernard Pirotte ,  Pierre Lestage ,  Laurence Danober ,  Daniel-Henri Caignard ,  Pierre Renard

    IPC分类号： C07D285/22 ,  A61K31/5415 ,  A61P25/24

    CPC分类号： C07D285/24

    摘要： Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group selected from alkylaminocarbonyl and optionally substituted alkyl, R2 represents hydrogen, halogen or a group selected from cycloalkyl and optionally substituted alkyl, R3 to R6, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, nitro, cyano, alkylsulphonyl, hydroxy, alkoxy, optionally substituted alkyl and optionally substituted amino, its optical isomers when they exist, and also their addition salts with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as AMPA modulators.

    摘要翻译： 式（I）化合物：其中：R F表示单氟或多氟 - 烷基或单氟或多氟环烷基烷基，R 1表示氢或选自烷基氨基羰基 和任选取代的烷基，R 2表示氢，卤素或选自环烷基和任选取代的烷基，R 3至R 6的基团，其中 可以相同或不同，各自表示选自氢，卤素，硝基，氰基，烷基磺酰基，羟基，烷氧基，任选取代的烷基和任选取代的氨基的原子或基团，当它们存在时的光学异构体，以及它们与 药学上可接受的酸或碱。 含有与AMPA调节剂有用的药用产品。