公开(公告)号：US06375584B1

公开(公告)日：2002-04-23

申请号：US09649439

申请日：2000-08-25

申请人： Stan Lee Shapiro

发明人： Stan Lee Shapiro

IPC分类号： A63B6900

CPC分类号： A63B69/002 ,  A63B2243/007

摘要： An apparatus for enhancing in simulated real-time environment, the skills of a football place kicker, center and holder, particularly the speed, distance, direction and angle of the kicks, by simulating charging lineman and providing simultaneous and integrally connected, resettable, visually displayed split-time and total elapsed timing feedback comprising uprights, a cross bar supporting a net, actuator switches for cross bar, timing means, and time display and reset means on the time display.

摘要翻译： 模拟实时环境，足球场踢球者，中心和持有人的技能，特别是踢球的速度，距离，方向和角度的装置，通过模拟充电轮辋并提供同时并整体连接，可重置的视觉 包括立柱的显示分时和总经过的定时反馈，支撑网的横杆，横杆的执行器开关，定时装置，以及时间显示上的时间显示和复位装置。

公开(公告)号：US06246782B1

公开(公告)日：2001-06-12

申请号：US08870709

申请日：1997-06-06

申请人： Gary Lee Shapiro ,  Davis ReGoalt Oliver, Jr.

发明人： Gary Lee Shapiro ,  Davis ReGoalt Oliver, Jr.

IPC分类号： G06K900

CPC分类号： G06T7/0012 ,  Y10S128/925

摘要： A system for automated detection of cancerous masses in mammograms initially identifies regions of interest (ROIs) using Fourier analysis (e.g., by means of an optical correlator). Context data is extracted from the mammogram for each ROI, such as size, location, ranking, brightness, density, and relative isolation from other ROIs. The pixels in the ROI are averaged together to create a smaller array of super-pixels, which are input into a first neural net. A second neural net receives the output values from the first neural net and the context data as inputs and generates an output score indicating whether the ROI contains a cancerous mass. The second neural net can also be provided with context data from another view of the same breast, the same view of the other breast, or a previous mammogram for the same patient.

摘要翻译： 用于乳腺X线照片中的癌质量的自动检测的系统使用傅里叶分析（例如，通过光学相关器）最初识别感兴趣的区域（ROI）。 从针对每个ROI的乳房X线照片提取上下文数据，例如尺寸，位置，等级，亮度，密度以及与其他ROI的相对隔离。 ROI中的像素被一起平均以创建更少的超像素阵列，其被输入到第一神经网络中。 第二神经网络接收来自第一神经网络和上下文数据的输出值作为输入，并产生指示ROI是否包含癌性质量的输出得分。 第二神经网络还可以提供来自同一乳房的另一视图，另一乳房的相同视图或相同患者的先前乳房X线照片的上下文数据。

公开(公告)号：US6116977A

公开(公告)日：2000-09-12

申请号：US182873

申请日：1998-10-30

申请人： Chaim T. Tanny ,  John Chan ,  Lee Shapiro

发明人： Chaim T. Tanny ,  John Chan ,  Lee Shapiro

IPC分类号： A45C1/12 ,  A47G1/06 ,  G07B15/00

CPC分类号： A45C1/12

摘要： The present invention is directed to a donation container system which includes a sensor for detecting the approach of one or more individuals to the container. The container system also includes a microprocessor and a speaker, so that when the sensor detects the approach of one or more individuals to the container, it sends a signal to the microprocessor which in turn communicates with a voice chip. The voice chip then sends an audio signal to an output speaker so as to produce an audio output.

摘要翻译： 本发明涉及一种捐赠容器系统，其包括用于检测一个或多个个人进入容器的方法的传感器。 容器系统还包括微处理器和扬声器，使得当传感器检测到一个或多个个人进入容器时，它向微处理器发送信号，微处理器又与语音芯片通信。 语音芯片然后将音频信号发送到输出扬声器以产生音频输出。

公开(公告)号：US20190102794A1

公开(公告)日：2019-04-04

申请号：US15722170

申请日：2017-10-02

申请人： Jillian Lee Shapiro ,  James Frederick Caruso ,  Jona Mici

发明人： Jillian Lee Shapiro ,  James Frederick Caruso ,  Jona Mici

IPC分类号： G06Q30/02 ,  H04L29/08

摘要： Systems and methods are described herein for monitoring consumer behavior on an individual level across a plurality of consumer data providers. The systems and methods described herein can receive consumer behavior data for an individual consumer. The consumer behavior data can be generated based on advertisements and digital advertisements assets relative to the individual consumer.

公开(公告)号：US20110112017A1

公开(公告)日：2011-05-12

申请号：US12814263

申请日：2010-06-11

申请人： Lee SHAPIRO ,  Charles A. DINARELLO ,  Eli LEWIS ,  Peter GOTTLIEB ,  Amy WALLACE ,  Aaron MICHELS ,  Gregory B. POTTS

发明人： Lee SHAPIRO ,  Charles A. DINARELLO ,  Eli LEWIS ,  Peter GOTTLIEB ,  Amy WALLACE ,  Aaron MICHELS ,  Gregory B. POTTS

IPC分类号： A61K38/17 ,  A61P3/10

CPC分类号： A61K38/57

摘要： Embodiments herein concern compositions and methods for treating diabetes in a subject.

摘要翻译： 本文的实施方案涉及用于治疗受试者的糖尿病的组合物和方法。

公开(公告)号：US07732696B1

公开(公告)日：2010-06-08

申请号：US12187206

申请日：2008-08-06

申请人： Lee Shapiro

发明人： Lee Shapiro

IPC分类号： G09B15/00

CPC分类号： G09B15/06 ,  G09B15/003 ,  G10H1/0016 ,  G10H1/32 ,  G10H2220/051

摘要： An instantly playable stringed instrument having a body, neck and fret spaces is provided. The instrument includes a plurality of strings. The strings are tuned such that in combination the sound they produce is an open E minor chord. The instantly playable stringed instrument may further include a plurality of indicators, each indicator corresponding to one fret space. Each indicator indicates a minor chord to be played by depressing all the strings within the fret space the indicator is associated with. The stringed instrument may further include a minor third string that has a color identification to distinguish it from the rest of the plurality of strings. The minor third string may be depressed on an adjacent fret space thereby converting the minor chord associated with the fret space having all strings depressed to a major chord.

摘要翻译： 提供了具有身体，颈部和毛孔空间的即时可播放的弦乐器。 仪器包括多个弦。 琴弦被调整，使得它们组合的声音是一个开放的E小和弦。 即时可播放的弦乐器还可以包括多个指示器，每个指示符对应于一个音柱空间。 每个指示符表示通过按下指示符相关联的空白区域中的所有字符串来播放的小和弦。 弦乐器还可以包括具有颜色识别以将其与多个弦的其余部分区分开的次要第三弦。 次要的第三弦可以在相邻的音柱空间上被压下，从而将与所有弦的颤音空间相关联的小和弦转换成主弦。

公开(公告)号：US20140221327A1

公开(公告)日：2014-08-07

申请号：US14169365

申请日：2014-01-31

申请人： Jules B. Puschett ,  Lee Shapiro

发明人： Jules B. Puschett ,  Lee Shapiro

IPC分类号： G01N33/53 ,  A61K31/585

CPC分类号： G01N33/53 ,  A61K31/585 ,  G01N33/743 ,  G01N2800/28 ,  G01N2800/40

摘要： Known or suspected traumatic brain injuries may be treated therapeutically by administering a therapeutically effective dose of resibufogenin. A preferred method for determining if a patient has a traumatic brain injury includes obtaining a body specimen from the patient, determining the concentration of marinobufagenin in the body specimen, comparing the concentration of marinobufagenin to the concentration in such body specimens in normal patients, and if the marinobufagenin concentration is substantially above the concentration of a normal patient, concluding traumatic brain injury exists. In a preferred embodiment, a substantial elevation is deemed to be an increase of about 30 percent above the marinobufagenin concentration of a normal patient. The body specimen may be blood, urine, or cerebrospinal fluid. If a substantial elevation is deemed to exist, the magnitude of the departure from the concentration of a normal patient may be employed in determining the timing and nature of treatment provided to the patient. The method may be repeated at predetermined intervals to monitor changes in the marinobufagenin with time.

摘要翻译： 可以通过施用治疗有效剂量的抗纤维蛋白原治疗来治疗已知或怀疑的创伤性脑损伤。 用于确定患者是否具有创伤性脑损伤的优选方法包括从患者获得身体标本，确定身体标本中海马素原基因的浓度，将正常患者中的马氏原虫基因的浓度与这些身体标本中的浓度进行比较，以及如果 造血干细胞因子浓度明显高于正常患者的浓度，结论存在创伤性脑损伤。 在优选的实施方案中，认为实质高程比普通患者的海因素原基因浓度高出约30％。 身体标本可能是血液，尿液或脑脊液。 如果认为存在实质性高程，则在确定提供给患者的治疗的时间和性质时可以采用偏离正常患者浓度的大小。 可以以预定的间隔重复该方法以随时间监测马铃薯白蛋白原的变化。

公开(公告)号：US08642568B2

公开(公告)日：2014-02-04

申请号：US13160735

申请日：2011-06-15

申请人： Jules B. Puschett ,  Lee Shapiro

发明人： Jules B. Puschett ,  Lee Shapiro

IPC分类号： A01N45/00 ,  A61K31/56 ,  A61K31/58

CPC分类号： G01N33/53 ,  A61K31/585 ,  G01N33/743 ,  G01N2800/28 ,  G01N2800/40

摘要： Known or suspected traumatic brain injuries may be treated therapeutically by administering a therapeutically effective dose of resibufogenin. A preferred method for determining if a patient has a traumatic brain injury includes obtaining a body specimen from the patient, determining the concentration of marinobufagenin in the body specimen, comparing the concentration of marinobufagenin to the concentration in such body specimens in normal patients, and if the marinobufagenin concentration is substantially above the concentration of a normal patient, concluding traumatic brain injury exists. In a preferred embodiment, a substantial elevation is deemed to be an increase of about 30 percent above the marinobufagenin concentration of a normal patient. The body specimen may be blood, urine, or cerebrospinal fluid. If a substantial elevation is deemed to exist, the magnitude of the departure from the concentration of a normal patient may be employed in determining the timing and nature of treatment provided to the patient. The method may be repeated at predetermined intervals to monitor changes in the marinobufagenin with time.

摘要翻译： 可以通过施用治疗有效剂量的抗纤维蛋白原治疗来治疗已知或怀疑的创伤性脑损伤。 用于确定患者是否具有创伤性脑损伤的优选方法包括从患者获得身体标本，确定身体标本中海马素原基因的浓度，将正常患者中的马氏原虫基因的浓度与这些身体标本中的浓度进行比较，以及如果 造血干细胞因子浓度明显高于正常患者的浓度，结论存在创伤性脑损伤。 在优选的实施方案中，认为实质高程比普通患者的海因素原基因浓度高出约30％。 身体标本可能是血液，尿液或脑脊液。 如果认为存在实质性高程，则在确定提供给患者的治疗的时间和性质时可以采用偏离正常患者浓度的大小。 可以以预定的间隔重复该方法以随时间监测马铃薯白蛋白原的变化。

公开(公告)号：US20110319372A1

公开(公告)日：2011-12-29

申请号：US13160735

申请日：2011-06-15

申请人： JULES B. PUSCHETT ,  LEE SHAPIRO

发明人： JULES B. PUSCHETT ,  LEE SHAPIRO

IPC分类号： A61K31/58 ,  A61P25/00 ,  G01N33/566

CPC分类号： G01N33/53 ,  A61K31/585 ,  G01N33/743 ,  G01N2800/28 ,  G01N2800/40

摘要： Known or suspected traumatic brain injuries may be treated therapeutically by administering a therapeutically effective dose of resibufogenin. A preferred method for determining if a patient has a traumatic brain injury includes obtaining a body specimen from the patient, determining the concentration of marinobufagenin in the body specimen, comparing the concentration of marinobufagenin to the concentration in such body specimens in normal patients, and if the marinobufagenin concentration is substantially above the concentration of a normal patient, concluding traumatic brain injury exists. In a preferred embodiment, a substantial elevation is deemed to be an increase of about 30 percent above the marinobufagenin concentration of a normal patient. The body specimen may be blood, urine, or cerebrospinal fluid. If a substantial elevation is deemed to exist, the magnitude of the departure from the concentration of a normal patient may be employed in determining the timing and nature of treatment provided to the patient. The method may be repeated at predetermined intervals to monitor changes in the marinobufagenin with time.

摘要翻译： 可以通过施用治疗有效剂量的抗纤维蛋白原治疗来治疗已知或怀疑的创伤性脑损伤。 用于确定患者是否具有创伤性脑损伤的优选方法包括从患者获得身体标本，确定身体标本中海马素原基因的浓度，将正常患者中的马氏原虫基因的浓度与这些身体标本中的浓度进行比较，以及如果 造血干细胞因子浓度明显高于正常患者的浓度，结论存在创伤性脑损伤。 在优选的实施方案中，认为实质高程比普通患者的海因素原基因浓度高出约30％。 身体标本可能是血液，尿液或脑脊液。 如果认为存在实质性高程，则在确定提供给患者的治疗的时间和性质时可以采用偏离正常患者浓度的大小。 可以以预定的间隔重复该方法以随时间监测马铃薯白蛋白原的变化。