公开(公告)号：US20130072506A1

公开(公告)日：2013-03-21

申请号：US13611491

申请日：2012-09-12

申请人： Lenka ZAHAJSKA ,  Jan Hanus ,  Lukas Spichal ,  Jiri Voller ,  Miroslav Strnad

发明人： Lenka ZAHAJSKA ,  Jan Hanus ,  Lukas Spichal ,  Jiri Voller ,  Miroslav Strnad

IPC分类号： A61K31/522 ,  C07D473/34 ,  A61Q19/08 ,  A61K8/49 ,  C12N5/071 ,  C07D473/36 ,  A61K31/52 ,  C07D473/32

CPC分类号： C07D473/34 ,  A61K8/4953 ,  A61Q19/00 ,  A61Q19/08 ,  C12N5/0625

摘要： 6,8-Disubstituted purines which can be used in drug and cosmetic compositions and/or applications are provided. These 6,8-disubstituted purines have a wide range of biological activities, including for example anti-inflammatory, anti-senescent, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. The 6,8-disubstituted purine compounds and compositions containing such 6,8-disubstituted purines provide growth-regulatory, differentiating, antisenescent and antiaging properties with improved selectivities and efficiencies and lower toxicities than analogues known heretofore.

摘要翻译： 提供了可用于药物和化妆品组合物和/或应用中的6,8-二取代嘌呤。 这些6,8-二取代的嘌呤具有广泛的生物活性，包括例如抗炎，抗衰老，以及其它在制药和化妆品应用中特别有用的活性。 含有这种6,8-二取代嘌呤的6,8-二取代嘌呤化合物和组合物提供生长调节，分化，抗衰老和抗衰老特性，与迄今为止已知的类似物相比具有改进的选择性和效率以及较低的毒性。