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公开(公告)号：US5405432A
公开(公告)日：1995-04-11
申请号：US108872
申请日：1993-08-18
CPC分类号： G01N30/8693 , G01N30/8658 , G01N30/8662 , G01N30/8672
摘要： The invention is a method for modifying a known chromatographic method without changing peak elution order and with little or no change in resolution. Column and operational parameters of a known method are systematically translated to ensure that a new chromatographic method having possibly different column and operational parameters has a chromatographic output with similar separation.
摘要翻译： 本发明是一种改变已知色谱法而不改变峰洗脱顺序并且几乎没有或没有改变分辨率的方法。 系统地翻译已知方法的色谱柱和操作参数，以确保具有可能不同色谱柱和操作参数的新色谱方法具有类似分离的色谱输出。
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公开(公告)号：US06634211B1
公开(公告)日：2003-10-21
申请号：US10147955
申请日：2002-05-16
申请人： Leonid M. Blumberg
发明人： Leonid M. Blumberg
IPC分类号： G01N3002
CPC分类号： G01N30/86 , G01N30/8658 , G01N30/8672 , G01N2030/025 , G01N2030/8804
摘要： A method is provided for translating from a first method for performing gas chromatographic analysis to a second method for performing gas chromatographic analysis in a gas chromatography system without changing a peak elution pattern. Unlike the known method translation techniques that work only with the constant pressure gas chromatographic analyses, the invention can translate the gas chromatographic methods where column pressure and/or carrier gas flow rate change during the analysis by an arbitrary program.
摘要翻译： 提供了用于从用于进行气相色谱分析的第一种方法转变为在气相色谱系统中进行气相色谱分析而不改变峰值洗脱图案的第二种方法的方法。 与仅通过恒压气相色谱分析工作的已知方法翻译技术不同，本发明可以转换气相色谱法，其中柱压和/或载气流量在分析期间通过任意程序改变。
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公开(公告)号：US5448239A
公开(公告)日：1995-09-05
申请号：US202311
申请日：1994-02-25
摘要： Analog-to-Digital Converter (A/D converter) consisting of several continuously integrating charge balancing (CB) conversion stages. During each conversion interval, all CB capacitors are discharged by a reference current. In each stage, the end of the discharge of the CB capacitor is detected by a zero crossing detector. Time intervals between the zero crossing events and corresponding discharge termination events represent time equivalents of quantization errors. Each stage, other than the first, converts the time equivalents of quantization errors of the previous stage. Output of the entire multistage A/D converter is combined from the outputs of all stages in a way which provides compensation of a quantization error of any stage by the output of the next stage. Quantization noise (sequence of quantization errors) of the entire A/D converter becomes the same as the N-time differenced (N-number of stages) quantization noise of the last stage. The differencing shapes spectral density of quantization noise in such a way that the largest portion of the noise energy becomes shifted outside of the signal bandwidth. The larger the number of stages, the smaller the in-band portion of the quantization noise. The out-of-band portion of quantization noise can be filtered out in the post-conversion digital signal processing.
摘要翻译： 由数字连续积分电荷平衡（CB）转换级组成的模数转换器（A / D转换器）。 在每个转换间隔期间，所有CB电容都通过参考电流放电。 在每个阶段，CB电容器的放电结束由过零检测器检测。 零交叉事件和相应的放电终止事件之间的时间间隔表示量化误差的等效时间。 除了第一级之外的每个阶段转换前一级的量化误差的时间等价物。 整个多级A / D转换器的输出从所有级的输出组合起来，其方法是通过下一级的输出提供任何级的量化误差的补偿。 整个A / D转换器的量化噪声（量化误差序列）与最后一级的N次差分（N级）量化噪声相同。 差分形式使得噪声能量的最大部分变得偏离信号带宽以外的量化噪声的频谱密度。 级数越大，量化噪声的带内部分越小。 量化噪声的带外部分可以在后转换数字信号处理中被滤除。
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公开(公告)号：US6153438A
公开(公告)日：2000-11-28
申请号：US859630
申请日：1997-05-20
CPC分类号： G01N30/8651 , G01N2030/8804 , G01N30/32 , G01N30/8631
摘要： A method for identifying analytes of interest by referencing to a retention factor database corresponding to a plurality of identified analytes that is independent of column dimensions and carrier gas type while dependent upon stationary phase type ratio and a relative temperature program. The retention factor database is generated on a reference GC system in which the column head pressure is adjusted to ensure high reproducibility of retention times by locking the column void time and/or the retention time of an identified analyte to a specific value such that accurate retention factors (k) can be calculated in accordance with the formula: ##EQU1## where VT is the void time of the column having a specified stationary phase and phase coating installed in a GC system operating in accordance to a specified temperature program (where time is expressed in units of column void time).
摘要翻译： 通过参考与多个识别的分析物相对应的保留因子数据库来识别感兴趣的分析物的方法，其独立于列尺寸和载气类型，同时依赖于固定相型比率和相对温度程序。 保留因子数据库是在参考GC系统上产生的，其中柱头压力被调整以通过将所确定的分析物的柱空隙时间和/或保留时间锁定到特定值来确保保留时间的高再现性，使得精确保留 因子（k）可以根据以下公式计算：其中VT是具有指定的固定相和相涂层的柱的空隙时间，其安装在根据指定温度程序操作的GC系统中（时间以单位表示 的列空闲时间）。
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5.发明授权
公开(公告)号：US6036747A
公开(公告)日：2000-03-14
申请号：US122273
申请日：1998-07-24
申请人： Leonid M. Blumberg , Alan D. Broske
发明人： Leonid M. Blumberg , Alan D. Broske
CPC分类号： G01N30/32 , G01N2030/8804
摘要： The present invention provides an improved method for calculating and adjusting the column head pressure of a GC instrument based on the column's plate capacity, N.sub.c, and film thickness, d.sub.s, measured ideally during the manufacturing process and identified with the column such that software associated with the GC instrument can calculate a new column head pressure based on the relationship between the plate capacity and film thickness of the existing column to the plate capacity and film thickness of the new or shortened column. The column head pressure of the GC is adjusted to the new column head pressure to provide a reduction in the column-to-column non-reproducibility error in retention times of all peaks.
摘要翻译： 本发明提供了一种用于计算和调整GC仪器的柱头压力的改进方法，其基于在制造过程中理想地测量的柱的板容量Nc和膜厚度ds，并且与柱识别，使得与 GC仪器可以根据现有柱的板容量和膜厚度与新的或缩短的柱的板容量和膜厚度之间的关系来计算新的柱头压力。 将GC的柱头压力调节到新的柱头压力，以降低所有峰的保留时间中的柱对柱不可重复性误差。
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公开(公告)号：US5987959A
公开(公告)日：1999-11-23
申请号：US36658
申请日：1998-03-06
CPC分类号： G01N30/32 , G01N30/8658 , G01N30/8668
摘要： The invention provides a method for automated matching of retention times obtained using a known chromatographic method having a defined set of column parameters and operating parameters to the retention times obtained using a new chromatographic method having a new set of column parameters, wherein the retention times of components separated in accordance with the new chromatographic method are matched to the retention times set forth in the known chromatographic methods. A procedure is described to adjust head pressure to compensate for differences in a new versus the original column, carrier gas, and column outlet pressure of the known method.
摘要翻译： 本发明提供了一种使用已知色谱法获得的保留时间自动匹配的方法，所述色谱方法具有定义的一组列参数和操作参数与使用具有新的一组列参数的新色谱方法获得的保留时间，其中保留时间 根据新的色谱方法分离的组分与已知色谱方法中列出的保留时间相匹配。 描述了一种程序来调节压头压力以补偿已知方法的新色谱柱与原始色谱柱，载气和色谱柱出口压力的差异。
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7.发明授权
公开(公告)号：US5827946A
公开(公告)日：1998-10-27
申请号：US846977
申请日：1997-04-30
CPC分类号： G01N30/8651 , G01N2030/8804 , G01N30/32 , G01N30/8631
摘要： The invention provides a method for developing a retention time database of identified analytes and their respective retention times in a reference Gas Chromatograph (GC) system under locked conditions for identification of unknown analytes of interest eluting from any GC system locked to the retention time database and may also be employed in combination with selective detection and or method translation for enhanced certainty of identification.
摘要翻译： 本发明提供了一种在锁定条件下在参考气相色谱（GC）系统中开发识别的分析物的保留时间数据库及其各自保留时间的方法，用于鉴定从锁定到保留时间数据库的任何GC系统洗脱的未知分析物， 也可以与选择性检测和/或方法转换结合使用以增强识别的确定性。
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