公开(公告)号：US4435574A

公开(公告)日：1984-03-06

申请号：US398910

申请日：1982-07-16

申请人： Valeria V. Kastron ,  Rasma O. Vitolin ,  Gunar Y. Dubur ,  Marita Y. Selga ,  Guntis V. Zarinsh ,  Natalya V. Kondratenko ,  Vladimir I. Popov ,  Alexandr A. Kolomeitsev ,  Lev M. Yagupolsky

发明人： Valeria V. Kastron ,  Rasma O. Vitolin ,  Gunar Y. Dubur ,  Marita Y. Selga ,  Guntis V. Zarinsh ,  Natalya V. Kondratenko ,  Vladimir I. Popov ,  Alexandr A. Kolomeitsev ,  Lev M. Yagupolsky

IPC分类号： A61K31/455 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/90 ,  C07D213/55

CPC分类号： C07D211/90

摘要： The present invention relates to derivatives of 1,4-dihydropyridine and, more specifically, to 2,6-dimethyl-3,5-dicarbomethoxy-4-(o-difluoromethylthiophenyl)-1,4-dihydropyridine having the formula ##STR1## The proposed compound features pronounced hypotensive activity of prolonged duration and is capable of producing a coronarodilating effect while having low toxicity and being useful for treating diseases of the cardiovascular system.

摘要翻译： 本发明涉及1,4-二氢吡啶的衍生物，更具体地说，涉及具有式“IMAGE”的2,6-二甲基-3,5-二甲氧基-4-（邻 - 二氟甲硫基苯基）-1,4-二氢吡啶并[ 所提出的化合物具有延长持续时间的明显的降血压活性，并且能够产生抗晕菌作用，同时具有低毒性并且可用于治疗心血管系统的疾病。

公开(公告)号：US4738965A

公开(公告)日：1988-04-19

申请号：US10393

申请日：1987-02-03

申请人： Valeria V. Kastron ,  Rasma O. Vitolin ,  Elena L. Khanina ,  Gunar Y. Dubur ,  Agris A. Kimenis ,  Natalya V. Kondratenko ,  Vladimir I. Popov ,  Lev M. Yagupolsky ,  Alexandr A. Kolomeitsev

发明人： Valeria V. Kastron ,  Rasma O. Vitolin ,  Elena L. Khanina ,  Gunar Y. Dubur ,  Agris A. Kimenis ,  Natalya V. Kondratenko ,  Vladimir I. Popov ,  Lev M. Yagupolsky ,  Alexandr A. Kolomeitsev

IPC分类号： A61K31/505 ,  A61P9/08 ,  A61P9/10 ,  C07D239/22 ,  C07D239/36

CPC分类号： C07D239/22

摘要： The present invention relates to organic chemistry.The novel compound 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine has the formula: ##STR1## Said compound displays coronary-dilating activity and can be utilized in medicine.

摘要翻译： 本发明涉及有机化学。 新化合物2-氧代-4-（2'-二氟甲硫基苯基）-5-甲氧基羰基-6-甲基-1,2,3,4-四氢嘧啶具有下式：所述化合物显示冠状动脉扩张活性，可以 用于医学。

公开(公告)号：US4219653A

公开(公告)日：1980-08-26

申请号：US1148

申请日：1979-01-05

申请人： Valeria V. Kastron ,  Rasma O. Vitolin ,  Jury A. Fialkov ,  Svetlana V. Shelyazhenko ,  Gunar Y. Dubur ,  Agris A. Kimenis ,  Lev M. Yagupolsky

发明人： Valeria V. Kastron ,  Rasma O. Vitolin ,  Jury A. Fialkov ,  Svetlana V. Shelyazhenko ,  Gunar Y. Dubur ,  Agris A. Kimenis ,  Lev M. Yagupolsky

IPC分类号： A61K31/4422 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61P9/12 ,  C07D211/90

CPC分类号： C07D211/90

摘要： The present invention relates to derivatives of 1,4-dihydropyridine and, more specifically, to 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydropyridine of the formula: ##STR1## This compound features a clearly pronounced hypotensive activity while being low-toxic, wherefore it can be used in medicine for treating hypertensive disease.

摘要翻译： 本发明涉及1,4-二氢吡啶的衍生物，更具体地说，涉及下式的2,6-二甲基-3,5-二甲氧基羰基-4-（邻 - 二氟甲氧基苯基）-1,4-二阴离子：该化合物具有明显的低血压活性，同时具有低毒性，因此可用于治疗高血压疾病的药物。

公开(公告)号：US4124456A

公开(公告)日：1978-11-07

申请号：US688912

申请日：1976-05-21

申请人： Lev M. Yagupolsky ,  Vladimir N. Zavatsky ,  Valery Y. Semeny ,  Konstantin N. Bildinov ,  Petr V. Serebrov ,  Alevtina A. Goncharenko ,  Alexandr V. Kirsanov ,  Mikhail I. Lyapunov ,  Ninel G. Feschenko

发明人： Lev M. Yagupolsky ,  Vladimir N. Zavatsky ,  Valery Y. Semeny ,  Konstantin N. Bildinov ,  Petr V. Serebrov ,  Alevtina A. Goncharenko ,  Alexandr V. Kirsanov ,  Mikhail I. Lyapunov ,  Ninel G. Feschenko

IPC分类号： C07F9/53 ,  C25B3/08 ,  C25B3/04

CPC分类号： C25B3/08 ,  C07F9/5304

摘要： Novel compounds, viz., tris(perfluoroalkyl)phosphine oxides have the following general formula ##STR1## where R.sub.F is a perfluoroalkyl of normal and iso-structure, having from 2 to 8 carbon atoms.The method of preparing said compounds consists in that trialkylphosphine oxide having the general formula R.sub.3 PO, where R = C.sub.8 -C.sub.8, is fluorinated electrochemically in a medium of anhydrous hydrogen fluoride; whenever trialkylphosphine oxides having the general formula R.sub.3 PO, where R = C.sub.5 - C.sub.8, are used as the starting material, they are first brominated in a medium of anhydrous hydrogen fluoride, with subsequent isolation of the end product.The proposed novel compounds can be used as solvents for salts of rare earth elements and as complexing agents in the separation of valuable metals.

摘要翻译： 新的化合物，即三（全氟烷基）氧化膦具有以下通式：其中RF是具有2-8个碳原子的正构和异构结构的全氟烷基。