公开(公告)号：US08338572B2

公开(公告)日：2012-12-25

申请号：US12570279

申请日：2009-09-30

Applicant: Gaetano J. Scuderi ,  Lewis S. Hanna ,  Robert Bowser

Inventor： Gaetano J. Scuderi ,  Lewis S. Hanna ,  Robert Bowser

IPC: C07K16/18 ,  C07K14/435

CPC classification number: G01N33/68 ,  G01N33/6887 ,  G01N2333/4722 ,  G01N2333/78 ,  G01N2800/102 ,  G01N2800/52

Abstract: Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for identifying treatment sites in the spine or joint for treatment of pain and inflammation by detecting the presence of, or increased levels of, fibronectin-aggrecan complexes. Methods for treating spinal or joint pain and inflammation are also provided.

Abstract translation: 提供了生物标志物，包括与脊髓或关节疼痛和炎症相关的分离的纤连蛋白 - 聚集蛋白聚糖复合物，以及用于其检测的方法。 还提供了用于通过检测纤连蛋白 - 聚集蛋白聚糖复合物的存在或增加水平来鉴定脊柱或关节中用于治疗疼痛和炎症的治疗部位的方法。 还提供了治疗脊髓或关节疼痛和炎症的方法。

公开(公告)号：US20130078246A1

公开(公告)日：2013-03-28

申请号：US13682454

申请日：2012-11-20

Applicant: Gaetano J. Scuderi ,  Lewis S. Hanna ,  Robert Bowser

Inventor： Gaetano J. Scuderi ,  Lewis S. Hanna ,  Robert Bowser

IPC: G01N33/68

CPC classification number: G01N33/68 ,  G01N33/6887 ,  G01N2333/4722 ,  G01N2333/78 ,  G01N2800/102 ,  G01N2800/52

Abstract: Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for identifying treatment sites in the spine or joint for treatment of pain and inflammation by detecting the presence of, or increased levels of, fibronectin-aggrecan complexes. Methods for treating spinal or joint pain and inflammation are also provided.

Abstract translation: 提供了生物标志物，包括与脊髓或关节疼痛和炎症相关的分离的纤连蛋白 - 聚集蛋白聚糖复合物，以及用于其检测的方法。 还提供了用于通过检测纤连蛋白 - 聚集蛋白聚糖复合物的存在或增加水平来鉴定脊柱或关节中用于治疗疼痛和炎症的治疗部位的方法。 还提供了治疗脊髓或关节疼痛和炎症的方法。

公开(公告)号：US20100098684A1

公开(公告)日：2010-04-22

申请号：US12570279

申请日：2009-09-30

Applicant: Gaetano J. Scuderi ,  Lewis S. Hanna ,  Robert Bowser

Inventor： Gaetano J. Scuderi ,  Lewis S. Hanna ,  Robert Bowser

IPC: A61K39/395 ,  C07K14/78 ,  G01N33/53 ,  A61K38/02 ,  A61K31/711 ,  A61K31/7105 ,  A61P19/02 ,  A61P37/06

CPC classification number: G01N33/68 ,  G01N33/6887 ,  G01N2333/4722 ,  G01N2333/78 ,  G01N2800/102 ,  G01N2800/52

Abstract: Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for identifying treatment sites in the spine or joint for treatment of pain and inflammation by detecting the presence of, or increased levels of, fibronectin-aggrecan complexes. Methods for treating spinal or joint pain and inflammation are also provided.

Abstract translation: 提供了生物标志物，包括与脊髓或关节疼痛和炎症相关的分离的纤连蛋白 - 聚集蛋白聚糖复合物，以及用于其检测的方法。 还提供了用于通过检测纤连蛋白 - 聚集蛋白聚糖复合物的存在或增加水平来鉴定脊柱或关节中用于治疗疼痛和炎症的治疗部位的方法。 还提供了治疗脊髓或关节疼痛和炎症的方法。