公开(公告)号：US20120015344A1

公开(公告)日：2012-01-19

申请号：US13068427

申请日：2011-05-11

申请人： Evangelyn C. Alocilia ,  Tracy L. Kamikawa ,  Dorothy Elizabeth Scott ,  Michael C. Kennedy ,  Pei Zhang ,  Malgorzata Mikolajczyk ,  Lilin Zhong

发明人： Evangelyn C. Alocilia ,  Tracy L. Kamikawa ,  Dorothy Elizabeth Scott ,  Michael C. Kennedy ,  Pei Zhang ,  Malgorzata Mikolajczyk ,  Lilin Zhong

IPC分类号： C12Q1/70 ,  C08G73/02 ,  C12M1/34 ,  C12N7/00 ,  B82Y15/00

CPC分类号： C08G73/0266 ,  B82Y15/00 ,  C08G2261/3221 ,  C08G2261/3223 ,  C08G2261/94 ,  C08G2261/964 ,  C08K3/22 ,  C08L65/00 ,  C12N2760/16111 ,  C12N2760/16211 ,  C12N2760/16311 ,  C08L79/02

摘要： The disclosure generally relates to a particulate composition formed from a conductive polymer bound to magnetic nanoparticles. The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding pair member (e.g., an antibody or a fragment thereof that specifically recognizes a virus strain or a virus surface protein) bound to the conductive polymer of the particulate composition. The disclosure further provides compositions, kits, detection apparatus, and methods for detecting specific viral strains including those with pandemic potential. In the various embodiments, a triplex including the BEAM nanoparticle, a virus or virally derived material (e.g. strain- and/or strain subtype specific viral surface protein or fragments thereof), and a viral strain subtype-specific binding pair member (e.g., a glycan that recognizes a specific virus strain subtype) is formed and detected, such as by use of a biosensor.

摘要翻译： 本发明一般涉及由与磁性纳米颗粒结合的导电聚合物形成的颗粒组合物。 颗粒组合物可以通过进一步包括结合对成员（例如，特异性识别病毒株或病毒表面蛋白的抗体或其片段）结合到生物增强的电活性磁性（BEAM）纳米颗粒组合物 导电聚合物。 本公开进一步提供了组合物，试剂盒，检测装置和用于检测特定病毒株的方法，包括具有大流行潜力的病毒株。 在各种实施方案中，包括BEAM纳米颗粒，病毒或病毒衍生的材料（例如菌株和/或菌株亚型特异性病毒表面蛋白或其片段）和病毒株亚型特异性结合对成员（例如， 形成并检测识别特定病毒株亚型的聚糖，例如通过使用生物传感器。