-
公开(公告)号:US07435540B2
公开(公告)日:2008-10-14
申请号:US11342208
申请日:2006-01-27
申请人: Neil Cashman , Eustache Paramithiotis , Sylvie La Boissière , Robert Lawton , Susan Francoeur, legal representative , Lisa Estey , Marc Pinard
发明人: Greg Francoeur
IPC分类号: G01N33/53 , G01N33/566
CPC分类号: G01N33/6896 , G01N2469/20 , G01N2500/00 , G01N2800/2828
摘要: The present invention features methods for identifying peptides that selectively bind to PrPSc or fragments thereof. The invention also features the use of such peptides in screening methods for the identification of candidate agents useful for the treatment of a prion disease.
摘要翻译: 本发明的特征在于鉴定选择性结合PrP SUP> Sc或其片段的肽的方法。 本发明还特征在于用于鉴定可用于治疗朊病毒病的候选药剂的筛选方法中使用这些肽。
-
公开(公告)号:US20060183156A1
公开(公告)日:2006-08-17
申请号:US11342208
申请日:2006-01-27
申请人: Neil Cashman , Eustache Paramithiotis , Sylvie La Boissiere , Robert Lawton , Greg Francoeur , Susan Francoeur , Lisa Estey , Marc Pinard
发明人: Neil Cashman , Eustache Paramithiotis , Sylvie La Boissiere , Robert Lawton , Greg Francoeur , Susan Francoeur , Lisa Estey , Marc Pinard
IPC分类号: G01N33/53
CPC分类号: G01N33/6896 , G01N2469/20 , G01N2500/00 , G01N2800/2828
摘要: The present invention features methods for identifying peptides that selectively bind to PrPSc or fragments thereof. The invention also features the use of such peptides in screening methods for the identification of candidate agents useful for the treatment of a prion disease.
摘要翻译: 本发明的特征在于鉴定选择性结合PrP SUP> Sc或其片段的肽的方法。 本发明还特征在于用于鉴定可用于治疗朊病毒病的候选药剂的筛选方法中使用这些肽。
-
公开(公告)号:US20050239139A1
公开(公告)日:2005-10-27
申请号:US11099128
申请日:2005-04-05
申请人: Lisa Estey , Reet Toomik
发明人: Lisa Estey , Reet Toomik
IPC分类号: C12N9/00 , G01N33/53 , G01N33/555 , G01N33/567 , G01N33/68
CPC分类号: G01N33/5306 , G01N33/6896 , G01N2800/2828
摘要: The invention provides improved methods and compositions for selectively binding and/or detecting an aggregating abnormal form of a protein in the presence of non-aggregating normal form of the protein.
摘要翻译: 本发明提供了在非聚集正常形式的蛋白质存在下选择性结合和/或检测聚集的异常形式的蛋白质的改进的方法和组合物。
-
-