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    Biological process for the production of ortho-aminophenols from nitroaromatic compounds using mutase
    1.
    发明授权
    Biological process for the production of ortho-aminophenols from nitroaromatic compounds using mutase 失效
    使用变位酶从硝基芳族化合物生产邻氨基苯酚的生物工艺

    公开(公告)号：US06797497B1

    公开(公告)日：2004-09-28

    申请号：US10076383

    申请日：2002-02-19

    申请人： Jim C. Spain ,  Lloyd J. Nadeau ,  Zhongqi He

    发明人： Jim C. Spain ,  Lloyd J. Nadeau ,  Zhongqi He

    IPC分类号： C12P1300

    CPC分类号： C12P13/001

    摘要： A process for the production of ortho-aminophenols from nitroarenes using a biocatalyst consisting of pure enzymes, partially purified enzymes, cell lysate, intact cells, or a metal reaction linked with a subsequent enzymatic reaction. The biocatalyst is an enzyme system that makes use of a nitroreductase enzyme that initially reduces the nitroarene to the hydroxylaminoarene and a mutase enzyme that converts the hydroxylaminoarene to an ortho-aminophenol. The biocatalyst can also consist of a coupled, two-step metal and enzyme reaction in which the metal, such as zinc, catalyzes the transformation of the nitroarene to the hydroxylaminoarene and the mutase then catalyzes the transformation of hydroxylaminoarene to the corresponding ortho-aminophenol.

    摘要翻译： 使用由纯酶，部分纯化的酶，细胞裂解物，完整细胞或与随后的酶反应连接的金属反应组成的生物催化剂从硝基芳烃生产邻氨基苯酚的方法。 生物催化剂是一种使用硝基还原酶的酶系统，其最初将硝基芳烃还原成羟基氨基芳烃，以及将羟基氨基芳烃转化为邻氨基苯酚的变位酶。 生物催化剂还可以由偶联的两步金属和酶反应组成，其中金属如锌催化硝基芳烃转化为羟基氨基芳烃和变性酶，然后催化羟基氨基芳烃转化成相应的邻氨基苯酚。

    Biocatalytic process for the production of ortho-aminophenols from chloramphenicol and analogs
    2.
    发明授权
    Biocatalytic process for the production of ortho-aminophenols from chloramphenicol and analogs 有权
    用于从氯霉素和类似物生产邻氨基苯酚的生物催化方法

    公开(公告)号：US08071340B1

    公开(公告)日：2011-12-06

    申请号：US11602435

    申请日：2006-11-02

    申请人： Lloyd J. Nadeau ,  Heather R. Luckarift ,  Jim C. Spain

    发明人： Lloyd J. Nadeau ,  Heather R. Luckarift ,  Jim C. Spain

    IPC分类号： C12P13/00

    CPC分类号： C12P13/02 ,  C12Y101/01284 ,  C12Y504/04003

    摘要： A process for the production of ortho-aminophenolic analogs of chloramphenicol using a biocatalyst consisting of pure enzymes, partially purified enzymes, cell lysate, intact cells, or a metal reaction linked with a subsequent enzymatic reaction. The biocatalyst is an enzyme system that makes use of a nitroreductase enzyme that initially reduces the nitroarene to the hydroxylaminoarene and a mutase enzyme that converts the hydroxylaminoarene to an ortho-aminophenol. The biocatalyst can also consist of a coupled, two-step metal and enzyme reaction in which the metal, such as zinc, catalyzes the transformation of the nitroarene to the hydroxylaminoarene and the mutase then catalyzes the transformation of hydroxylaminoarene to the corresponding ortho-aminophenol.

    摘要翻译： 使用由纯酶，部分纯化的酶，细胞裂解物，完整细胞或与随后的酶反应连接的金属反应组成的生物催化剂来生产氯霉素的邻氨基苯酚类似物的方法。 生物催化剂是一种使用硝基还原酶的酶系统，其最初将硝基芳烃还原成羟基氨基芳烃，以及将羟基氨基芳烃转化为邻氨基苯酚的变位酶。 生物催化剂还可以由偶联的两步金属和酶反应组成，其中金属如锌催化硝基芳烃转化为羟基氨基芳烃和变性酶，然后催化羟基氨基芳烃转化成相应的邻氨基苯酚。