-
公开(公告)号：US07807363B2
公开(公告)日：2010-10-05
申请号：US11680416
申请日：2007-02-28
CPC分类号： G01N33/6893 , A61K31/21 , A61K31/4196 , A61K31/56 , C12Q1/26 , C12Q1/6851 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N2500/00 , G01N2800/168
摘要： The present invention concerns a method for diagnosing or monitoring elevated intraocular pressure or glaucoma in a patient comprising providing a biological sample from the patient and measuring the expression level of a superoxide dismutase-2 (SOD-2) gene in the biological sample. The present invention also concerns methods for treating glaucoma or elevated intraocular pressure in a patient comprising administering to a patient an effective amount of an agent that modulates SOD-2 expression or SOD-2 activity.
摘要翻译： 本发明涉及用于诊断或监测患者中升高的眼内压或青光眼的方法，包括从患者提供生物样品并测量生物样品中超氧化物歧化酶-2（SOD-2）基因的表达水平。 本发明还涉及治疗患者青光眼或升高的眼内压的方法，包括向患者施用有效量的调节SOD-2表达或SOD-2活性的药剂。
-
2.发明申请RNAI-MEDIATED INHIBITION OF FRIZZLED RELATED PROTEIN-1 FOR TREATMENT OF GLAUCOMA 有权用于治疗葡萄球菌的相关蛋白-1的RNAi介导的抑制公开(公告)号：US20120178795A1
公开(公告)日：2012-07-12
申请号：US13429913
申请日：2012-03-26
IPC分类号： A61K31/713 , A61P27/06
CPC分类号： C12N15/113 , A61K9/0048 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/316 , C12N2310/321 , C12N2310/351
摘要： RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
摘要翻译： 提供RNA干扰用于抑制卷曲相关蛋白-1 mRNA表达，特别是用于治疗患有青光眼或有发展青光眼风险的患者。
-
3.发明申请USE OF SERUM AMYLOID A GENE IN DIAGNOSIS AND TREATMENT OF GLAUCOMA AND IDENTIFICATION OF ANTI-GLAUCOMA AGENTS 审中-公开血清淀粉样蛋白A基因在糖尿病诊断和治疗中的应用及抗GLAUCOMA代谢鉴定公开(公告)号：US20100063052A1
公开(公告)日：2010-03-11
申请号：US12617795
申请日：2009-11-13
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/4439 , A61K31/506 , A61P27/02
CPC分类号： A61K31/202 , A61K31/337 , A61K31/353 , A61K31/365 , A61K31/395 , A61K31/397 , A61K31/4439 , A61K31/519 , A61K31/7072
摘要： The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
摘要翻译： 本发明提供了用于治疗青光眼的组合物和方法，用于诊断青光眼的方法，以及用于鉴定可用于治疗青光眼的药剂的方法。 更具体地，本发明描述了调节血清淀粉样蛋白A表达的试剂的用途。
-
4.发明申请INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA 审中-公开GLYCOGEN SYNTHASE KINASE-3（GSK-3）用于治疗GLAUCOMA的抑制剂公开(公告)号：US20090312390A1
公开(公告)日：2009-12-17
申请号：US12545611
申请日：2009-08-21
申请人： Mark R. Hellberg , Abbot F. Clark , Iok-Hou Pang , Peggy Elizabeth Hellberg , Loretta Graves McNatt , Wan-Heng Wang
发明人： Mark R. Hellberg , Abbot F. Clark , Iok-Hou Pang , Peggy Elizabeth Hellberg , Loretta Graves McNatt , Wan-Heng Wang
IPC分类号： A61K31/404 , A61K31/4015
CPC分类号： A61K9/0048 , A61K31/4015 , A61K31/404 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/55
摘要： The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
摘要翻译： 公开了使用可用于治疗青光眼的GSK-3抑制剂。
-
5.发明授权RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma 有权RNAi介导的卷曲相关蛋白-1抑制治疗青光眼公开(公告)号：US07947660B2
公开(公告)日：2011-05-24
申请号：US11373376
申请日：2006-03-10
CPC分类号： C12N15/113 , A61K9/0048 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/316 , C12N2310/321 , C12N2310/351
摘要： RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
摘要翻译： 提供RNA干扰用于抑制卷曲相关蛋白-1 mRNA表达，特别是用于治疗患有青光眼或有发展青光眼风险的患者。
-
6.发明申请Use of Serum Amyloid A Gene in Diagnosis and Treatment of Glaucoma and Identification of Anti-Glaucoma Agents 审中-公开血清淀粉样蛋白A基因在青光眼诊断和治疗中的应用及抗青光眼药物的鉴定公开(公告)号：US20120064532A1
公开(公告)日：2012-03-15
申请号：US13226640
申请日：2011-09-07
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： A61K38/046 , A61K31/385 , G01N33/5023 , G01N2333/4709 , G01N2500/02 , G01N2800/168
摘要： The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
摘要翻译： 本发明提供了用于治疗青光眼的组合物和方法，用于诊断青光眼的方法，以及用于鉴定可用于治疗青光眼的药剂的方法。 更具体地，本发明描述了调节血清淀粉样蛋白A表达的试剂的用途。
-
7.发明授权Use of serum amyloid A gene in diagnosis and treatment of glaucoma and identification of anti-glaucoma agents 失效血清淀粉样蛋白A基因在青光眼诊断和治疗中的应用及抗青光眼药物的鉴定公开(公告)号：US07662389B2
公开(公告)日：2010-02-16
申请号：US11615454
申请日：2006-12-22
IPC分类号： A61K39/00
CPC分类号： A61K31/202 , A61K31/337 , A61K31/353 , A61K31/365 , A61K31/395 , A61K31/397 , A61K31/4439 , A61K31/519 , A61K31/7072
摘要： The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.
摘要翻译： 本发明提供了用于治疗青光眼的组合物和方法，用于诊断青光眼的方法，以及用于鉴定可用于治疗青光眼的药剂的方法。 更具体地，本发明描述了调节血清淀粉样蛋白A表达的试剂的用途。
-
8.发明授权RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma 有权RNAi介导的卷曲相关蛋白-1抑制治疗青光眼公开(公告)号：US09040494B2
公开(公告)日：2015-05-26
申请号：US13429913
申请日：2012-03-26
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , A61K38/00
CPC分类号： C12N15/113 , A61K9/0048 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/316 , C12N2310/321 , C12N2310/351
摘要： RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
摘要翻译： 提供RNA干扰用于抑制卷曲相关蛋白-1 mRNA表达，特别是用于治疗患有青光眼或有发展青光眼风险的患者。
-
9.发明授权RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma 有权RNAi介导的卷曲相关蛋白-1抑制治疗青光眼公开(公告)号：US08173617B2
公开(公告)日：2012-05-08
申请号：US13084944
申请日：2011-04-12
CPC分类号： C12N15/113 , A61K9/0048 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/316 , C12N2310/321 , C12N2310/351
摘要： RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
摘要翻译： 提供RNA干扰用于抑制卷曲相关蛋白-1 mRNA表达，特别是用于治疗患有青光眼或有发展青光眼风险的患者。
-
10.发明申请RNAI-MEDIATED INHIBITION OF FRIZZLED RELATED PROTEIN-1 FOR TREATMENT OF GLAUCOMA 有权用于治疗葡萄球菌的相关蛋白-1的RNAi介导的抑制公开(公告)号：US20110190381A1
公开(公告)日：2011-08-04
申请号：US13084944
申请日：2011-04-12
IPC分类号： A61K31/7088 , A61P27/06
CPC分类号： C12N15/113 , A61K9/0048 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/316 , C12N2310/321 , C12N2310/351
摘要： RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.
摘要翻译： 提供RNA干扰用于抑制卷曲相关蛋白-1 mRNA表达，特别是用于治疗患有青光眼或有发展青光眼风险的患者。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.016 秒)
