公开(公告)号：US06844343B1

公开(公告)日：2005-01-18

申请号：US10070976

申请日：2000-09-11

申请人： Wolfgang Pfleiderer ,  Harald Schmidt ,  Lothar Fröhlich ,  Peter Kotsonis ,  Shahriyar Taghavi-Moghadam

发明人： Wolfgang Pfleiderer ,  Harald Schmidt ,  Lothar Fröhlich ,  Peter Kotsonis ,  Shahriyar Taghavi-Moghadam

IPC分类号： C07D239/50 ,  A61K31/519 ,  A61K31/5377 ,  A61P1/04 ,  A61P9/00 ,  A61P9/02 ,  A61P9/10 ,  A61P13/12 ,  A61P25/00 ,  A61P25/06 ,  A61P25/08 ,  A61P25/28 ,  A61P31/04 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D239/46 ,  C07D475/08 ,  C07D487/04 ,  A61K31/4985

CPC分类号： C07D239/46 ,  C07D475/08

摘要： Compounds of formula (I), where preferably: A=a bridge of partial formula (II) or (III), R1 and R2=independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R3=H, —CO-Alkyl, or —CO-Aryl, R4=Aryl, —CO—O-Aryl or —CO-Aryl and R5=H, are potent inhibitors of NO-synthase and are suitable as pharmaceutical agents of prophylaxis and treatment of disease states associates with a disturbed NO metabolism.

摘要翻译： 式（I）的化合物，其中优选：A =部分式（II）或（III）的桥，R 1和R 2独立地是（取代的）烷基，芳基或芳烷基，或一起形成杂环 ，R 3 = H，-CO-烷基或-CO-芳基，R 4 =芳基，-CO-O-芳基或-CO-芳基且R 5 = H是有效的NO抑制剂 并且适合作为与受干扰的NO代谢相关联的疾病状态的预防和治疗的药剂。

公开(公告)号：US07687654B2

公开(公告)日：2010-03-30

申请号：US12029493

申请日：2008-02-12

申请人： Lothar Fröhlich ,  Stephane Jacob ,  Michael Popall ,  Ruth Houbertz-Krauss

发明人： Lothar Fröhlich ,  Stephane Jacob ,  Michael Popall ,  Ruth Houbertz-Krauss

IPC分类号： C07F7/08

CPC分类号： C08G77/14 ,  C08G77/20

摘要： A silane resin that can be structured photochemically and/or thermally is obtained by at least partial condensation of a mixture of a) at least one silane compound RaR2bSiX4-a-b wherein R is a group polymerizable photochemically and/or thermally via an organic group by radical or cationic polymerization; R2 is a straight-chain, branched, or cyclic C1-C12 alkyl group; X is identical or different and is a leaving group; a is 1 or 2; b is 0 or 1; a+b is not more than 2; and b) at least one silanediol R12Si(OH)2 wherein R1 is identical or different and is a straight-chain, branched, or cyclic C1-C12 alkyl group or a group polymerizable photochemically and/or thermally via an organic group by radical or cationic polymerization, provided the group does not contain aryl. The silane resins have dielectric properties useful in extremely high frequency applications.

摘要翻译： 可通过光化学和/或热结构形成的硅烷树脂通过a）至少一种硅烷化合物RaR2bSiX4-ab的混合物的至少部分缩合获得，其中R是通过基团可光化学和/或热通过有机基团可聚合的基团 或阳离子聚合; R2是直链，支链或环状的C 1 -C 12烷基; X相同或不同，为离去组; a是1或2; b为0或1; a + b不大于2; 和b）至少一种硅烷二醇R 12 Si（OH）2，其中R 1相同或不同，并且是直链，支链或环状的C 1 -C 12烷基或通过有机基团可光化和/或热自由基或/ 阳离子聚合，条件是该基团不含芳基。 硅烷树脂具有在极高频应用中有用的介电特性。

公开(公告)号：US06949616B2

公开(公告)日：2005-09-27

申请号：US10324079

申请日：2002-12-20

申请人： Stéphane Jacob ,  Lothar Fröhlich ,  Konrad Olma ,  Michael Popall ,  Frank Kahlenberg

发明人： Stéphane Jacob ,  Lothar Fröhlich ,  Konrad Olma ,  Michael Popall ,  Frank Kahlenberg

IPC分类号： B01D71/70 ,  H01M8/1037 ,  H01M8/1048 ,  H01M8/1072 ,  C08G77/20

CPC分类号： C08L83/08 ,  B01D71/70 ,  C08G77/26 ,  C08G77/28 ,  H01M8/1037 ,  H01M8/1048 ,  H01M8/1074 ,  Y02P70/56

摘要： This invention relates to a silane-resin composition that can be obtained by at least partial hydrolytic condensation of at least the following components: (1) one or more sulfonic acid group-containing silane(s) with at least one group that can be cleaved under hydrolytic conditions, (2) one or more styryl-functionalized silane(s) and (3) one or more silane(s) that carry a nitrogen-containing heterocyclic compound, an amine group or a sulfonamide group with at least one group that can be cleaved under hydrolytic conditions, and mixing of the components before, during or after the hydrolytic condensation, as well as a process for the production of this composition. With the silane resin that is obtained, proton-conductive, organically cross-linked heteropolysiloxanes can be produced that are suitable for PEMFC in a layer or membrane form as proton-conductive systems. Their proton conductivity can be further increased by the addition of suitable liquids.

摘要翻译： 本发明涉及可以通过至少以下组分至少部分水解缩合获得的硅烷 - 树脂组合物：（1）一种或多种含有磺酸基的硅烷与至少一个可被切割的基团 在水解条件下，（2）一种或多种苯乙烯基官能化的硅烷和（3）一种或多种含有至少一个基团的含氮杂环化合物，胺基或磺酰胺基团的硅烷， 可以在水解条件下裂解，并且在水解缩合之前，期间或之后混合组分，以及制备该组合物的方法。 使用得到的硅烷树脂，可以制备质子传导性有机交联杂多硅氧烷，其适用于作为质子传导系统的层或膜形式的PEMFC。 通过加入合适的液体可以进一步提高其质子传导性。

公开(公告)号：US07470761B2

公开(公告)日：2008-12-30

申请号：US11208553

申请日：2005-08-23

申请人： Stéphane Jacob ,  Lothar Fröhlich ,  Konrad Olma ,  Michael Popall ,  Frank Kahlenberg

发明人： Stéphane Jacob ,  Lothar Fröhlich ,  Konrad Olma ,  Michael Popall ,  Frank Kahlenberg

IPC分类号： C08F30/08

CPC分类号： C08L83/08 ,  B01D71/70 ,  C08G77/26 ,  C08G77/28 ,  H01M8/1037 ,  H01M8/1048 ,  H01M8/1074 ,  Y02P70/56

摘要： This invention relates to a silane-resin composition that can be obtained by at least partial hydrolytic condensation of at least the following components: (1) one or more sulfonic acid group-containing silane(s) with at least one group that can be cleaved under hydrolytic conditions, (2) one or more styryl-functionalized silane(s) and (3) one or more silane(s) that carry a nitrogen-containing heterocyclic compound, an amine group or a sulfonamide group with at least one group that can be cleaved under hydrolytic conditions, and mixing of the components before, during or after the hydrolytic condensation, as well as a process for the production of this composition. With the silane resin that is obtained, proton-conductive, organically cross-linked heteropolysiloxanes can be produced that are suitable for PEMFC in a layer or membrane form as proton-conductive systems. Their proton conductivity can be further increased by the addition of suitable liquids.

摘要翻译： 本发明涉及可以通过至少以下组分至少部分水解缩合获得的硅烷 - 树脂组合物：（1）一种或多种含有磺酸基的硅烷与至少一个可被切割的基团 在水解条件下，（2）一种或多种苯乙烯基官能化的硅烷和（3）一种或多种含有至少一个基团的含氮杂环化合物，胺基或磺酰胺基团的硅烷， 可以在水解条件下裂解，并且在水解缩合之前，期间或之后混合组分，以及制备该组合物的方法。 使用得到的硅烷树脂，可以制备质子传导性有机交联杂多硅氧烷，其适用于作为质子传导系统的层或膜形式的PEMFC。 通过加入合适的液体可以进一步提高其质子传导性。

公开(公告)号：US06984747B2

公开(公告)日：2006-01-10

申请号：US10313007

申请日：2002-12-06

申请人： Stéphane Jacob ,  Lothar Fröhlich ,  Konrad Olma ,  Michael Popall ,  Frank Kahlenberg

发明人： Stéphane Jacob ,  Lothar Fröhlich ,  Konrad Olma ,  Michael Popall ,  Frank Kahlenberg

IPC分类号： C07F7/04

CPC分类号： C07F7/1876

摘要： The invention relates to a method for preparing silanes comprising styryl groups, said silanes being represented by the general formula (I): (St)bSiR′aR4−a−b with improved yields through a reaction with magnesium in a solvent mixture comprising from 30:70 to 70:30 (v/v) of diethyl ether and tetrahydrofuran.

摘要翻译： 本发明涉及一种制备包含苯乙烯基的硅烷的方法，所述硅烷由通式（I）表示：<？in-line-formula description =“In-line Formulas”end =“lead”？>（St） α-in-line-formula description =“In-line Formulas”end =“tail”？ >与包含30:70至70:30（v / v）二乙醚和四氢呋喃的溶剂混合物中的镁反应，产率提高。

公开(公告)号：US07348393B2

公开(公告)日：2008-03-25

申请号：US10491588

申请日：2002-10-04

申请人： Lothar Fröhlich ,  Stéphane Jacob ,  Michael Popall ,  Ruth Houbertz-Krauss

发明人： Lothar Fröhlich ,  Stéphane Jacob ,  Michael Popall ,  Ruth Houbertz-Krauss

IPC分类号： C08G77/20

CPC分类号： C08G77/14 ,  C08G77/20

摘要： A silane resin that can be structured photochemically and/or thermally is obtained by at least partial condensation of a mixture of a) at least one silane compound RaR2bSiX4-a-b wherein R is a group polymerizable photochemically and/or thermally via an organic rest by radical or cationic polymerization; R2 is a straight-chain, branched, or cyclic C1-C12 alkyl group; X is identical or different and is a leaving group; a is 1 or 2; b is 0 or 1; a+b is not more than 2; and b) at least one silanediol R12Si(OH)2 wherein R1 is identical or different and is a straight-chain, branched, or cyclic C1-C12 alkyl group or a group polymerizable photochemically and/or thermally via an organic rest by radical or cationic polymerization, provided the group does not contain aryl. The silane resins have dielectric properties useful in extremely high frequency applications.

摘要翻译： 可通过光化学和/或热结构的硅烷树脂通过a）至少一种硅烷化合物R 2的混合物的至少部分缩合获得， 其中R是通过自由基或阳离子聚合通过有机残基可光化学和/或热可聚合的基团; R 2是直链，支链或环状C 1 -C 12烷基; X相同或不同，为离去组; a是1或2; b为0或1; a + b不大于2; 和b）至少一种硅烷二醇R 1 2 Si（OH）2 2其中R 1是相同或不同的 并且是直链，支链或环状C 1 -C 12烷基或通过自由基或阳离子聚合通过有机残基可光化和/或热可聚合的基团 ，条件是该基团不含芳基。 硅烷树脂具有在极高频应用中有用的介电特性。