公开(公告)号：US20050201505A1

公开(公告)日：2005-09-15

申请号：US10913950

申请日：2004-08-07

申请人： Michael Welch ,  Lucie Tang ,  Douglas Rowland

发明人： Michael Welch ,  Lucie Tang ,  Douglas Rowland

IPC分类号： B01D20060101 ,  G21G1/06

CPC分类号： H05H6/00 ,  G21G1/10

摘要： An automated process for preparing and recovering 76Br, 77Br and 124I comprises (I) bombarding enriched 76 or 77Se or enriched 124Te with a beam of protons on a targeted disk respectively to produce 76Br, 77Br and 124I respectively wherein the target is selected from (a) a round tungsten disk with a depression at its center and (b) an inclined target having about a 20° inclination with respect to the beam direction and (II) recovering the 76Br, 77Br and 124I in an automated process comprising by placing the irradiated target face up in a quartz tube in the center of a high temperature furnace utilizing a target holder and heating the irradiated target sufficient to release and recover 76Br, 77Br and 124I therefrom.

摘要翻译： 用于制备和回收76 Br，76 Br和124的自动化方法包括（I）轰击富集的76或77 / 在目标盘上分别具有一束质子束的SUP> Se或富集的124 Te，以产生76 Br Br，以及< 其目标选自（a）在其中心具有凹陷的圆形钨盘，（b）相对于光束方向具有大约20度倾斜的倾斜目标，（II）回收 在自动化过程中包括通过将照射的目标物体朝上放置在石英管的中心位置的自动化过程中，将76 Br，77 Br和124 I 高温炉利用目标保持器并加热照射的靶足以释放并从其中回收和/或从其中回收和/或从其中回收。

公开(公告)号：US20060004491A1

公开(公告)日：2006-01-05

申请号：US10914617

申请日：2004-08-09

申请人： Michael Welch ,  Lucie Tang ,  Gregory Gaehle ,  Jason Lewis

发明人： Michael Welch ,  Lucie Tang ,  Gregory Gaehle ,  Jason Lewis

IPC分类号： G05B21/00

CPC分类号： G05B19/418 ,  A61K51/1282 ,  B01D15/10 ,  B01D15/361 ,  B01D15/363 ,  G21G1/001 ,  G21G4/08 ,  G21G2001/0094

摘要： A novel method for separating an irradiated 60Cu or 61Cu or 64Cu respectively from a composition containing 60Ni or 61Ni or 64Ni respectively therein comprises dissolving the irradiated 60Cu or 61Cu or 64Cu in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising 60Ni or 61Ni or 64Ni ions. In an aspect the eluent is further processed for 60Ni or 61Ni or 64Ni recovery and recycling to prepare future targets. In an aspect 60Cu or 61Cu or 64Cu respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the 60Cu or 61Cu or 64Cu for further use or labeling. An enhanced process for labeling compounds with highly purified 60Cu, 61Cu or 64Cu comprises loading 60Cu, 61Cu and 64Cu elute onto a concentrating cartridge, collecting the 0.5N HCl eluent and admixing therewith 10-μL of ligand and 3N HCl solution in a reaction line to form a 60 or 61 or 64Cu labeled product. In an aspect a further purification step comprises loading 10-mL sterile water into the reaction line and through the C18 Sep-Pak cartridge to further purify the labeled product which is adherent in the cartridge and recovering 60Cu, 61Cu and 64Cu each as a separate and independent purified product.