利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.021 秒)

    Carbon monoxide as a biomarker and therapeutic agent
    3.
    发明授权
    Carbon monoxide as a biomarker and therapeutic agent 有权
    一氧化碳作为生物标志物和治疗剂

    公开(公告)号：US07678390B2

    公开(公告)日：2010-03-16

    申请号：US10053535

    申请日：2002-01-15

    申请人： Augustine M. K. Choi ,  Leo E. Otterbein

    发明人： Augustine M. K. Choi ,  Leo E. Otterbein

    IPC分类号： A61K33/00 ,  A61P1/00

    CPC分类号： A61K33/00 ,  A61K2300/00

    摘要： The present invention relates to the use of carbon monoxide (CO) as a biomarker and therapeutic agent of heart, lung, liver, spleen, brain, skin and kidney diseases and other conditions and disease states including, for example, asthma, emphysema, bronchitis, adult respiratory distress syndrome, sepsis, cystic fibrosis, pneumonia, interstitial lung diseases, idiopathic pulmonary diseases, other lung diseases including primary pulmonary hypertension, secondary pulmonary hypertension, cancers, including lung, larynx and throat cancer, arthritis, wound healing, Parkinson's disease, Alzheimer's disease, peripheral vascular disease and pulmonary vascular thrombotic diseases such as pulmonary embolism. CO may be used to provide anti-inflammatory relief in patients suffering from oxidative stress and other conditions especially including sepsis and septic shock. In addition, carbon monoxide may be used as a biomarker or therapeutic agent for reducing respiratory distress in lung transplant patients and to reduce or inhibit oxidative stress and inflammation in transplant patients.

    摘要翻译： 本发明涉及一氧化碳（CO）作为心脏，肺，肝，脾，脑，皮肤和肾脏疾病以及其他病症和疾病状态的生物标志物和治疗剂的用途，包括例如哮喘，肺气肿，支气管炎 ，成人呼吸窘迫综合征，败血症，囊性纤维化，肺炎，间质性肺病，特发性肺部疾病，其他肺部疾病，包括原发性肺动脉高压，继发性肺动脉高压，包括肺，喉和咽喉癌，关节炎，伤口愈合，帕金森病 ，阿尔茨海默病，外周血管疾病和肺血栓性血栓性疾病如肺栓塞。 CO可用于在患有氧化应激和其他病症的患者中提供消炎缓解，特别是包括败血症和败血性休克。 此外，一氧化碳可用作生物标志物或治疗剂，用于减少肺移植患者的呼吸窘迫，并减少或抑制移植患者的氧化应激和炎症。