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公开(公告)号：US20140234830A1
公开(公告)日：2014-08-21
申请号：US14130705
申请日：2012-07-06
Applicant: Maurice Exner , Luca Jacky , Yin-Peng Chen , Huong Mai , Michelle M. Tabb , Michael Aye
Inventor： Maurice Exner , Luca Jacky , Yin-Peng Chen , Huong Mai , Michelle M. Tabb , Michael Aye
CPC classification number: C12Q1/701 , C12Q1/68 , C12Q1/6846 , C12Q1/686 , C12Q1/689 , C12Q1/70 , C12Q2527/101 , C12Q2527/125
Abstract: Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction.
Abstract translation: 提供的是使用直接扩增从微生物鉴定靶核酸的存在或不存在的方法，而不提取核酸的步骤，但是保留测定提取的核酸的方法的基本相同的特异性和灵敏度。 还提供允许直接扩增样品的试剂混合物，而不需要提取核酸步骤。
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公开(公告)号：US20090197262A1
公开(公告)日：2009-08-06
申请号：US12116364
申请日：2008-05-07
Applicant: Michelle M. Tabb , Ming-Chou Lee , Lilly I. Kong , Ning Lu , Michael Aye , Fan Chen , Jules Chen
Inventor： Michelle M. Tabb , Ming-Chou Lee , Lilly I. Kong , Ning Lu , Michael Aye , Fan Chen , Jules Chen
CPC classification number: C12Q1/689 , C12Q2600/16
Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
Abstract translation: 本文公开了分别通过检测IS481和IS1001基因组插入序列的存在来检测百日咳博德特氏菌和副百日咳杆菌的方法和组合物。
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公开(公告)号：US08354230B2
公开(公告)日：2013-01-15
申请号：US11963699
申请日：2007-12-21
Applicant: Jules Chen , Lilly I. Kong , Ming-Chou Lee , Fan Chen , Michelle M. Tabb , Michael Aye
Inventor： Jules Chen , Lilly I. Kong , Ming-Chou Lee , Fan Chen , Michelle M. Tabb , Michael Aye
CPC classification number: C12Q1/701
Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.
Abstract translation: 本发明一般涉及A型流感，B型流感，呼吸道合胞病毒A和呼吸道合胞病毒B的分子检测，以鉴定病毒感染患者。 因此，公开了方法和组合物以确定含有来自A型流感，B型流感，呼吸道合胞病毒A和/或呼吸道合胞病毒B的M基因的一种或多种靶核酸的样品中病毒病原体的存在或不存在。
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公开(公告)号：US20090226889A1
公开(公告)日：2009-09-10
申请号：US12014063
申请日：2008-01-14
Applicant: Fan Chen , Lilly I. Kong , Ming-Chou Lee , Jules Chen , Michelle M. Tabb , Michael Aye
Inventor： Fan Chen , Lilly I. Kong , Ming-Chou Lee , Jules Chen , Michelle M. Tabb , Michael Aye
IPC: C12Q1/70
CPC classification number: C12Q1/705
Abstract: The present invention generally relates to a molecular test of enterovirus, herpes simplex virus-1 and -2, and/or Varicella-Zoster virus, in order to identify patients with a viral infection, in particular a viral infection of the central nervous system. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a biological sample comprising, wherein the target nucleic acids comprise the 5′ UTR of the enterovirus genome, UL29 of herpes simplex virus and gene 36 of Varicella-Zoster virus.
Abstract translation: 本发明一般涉及肠病毒，单纯疱疹病毒-1和-2和/或水痘带状疱疹病毒的分子检测，以便鉴定病毒感染的病人，特别是中枢神经系统的病毒感染。 因此，公开了确定生物样品中病毒病原体的存在或不存在的方法和组合物，其包含其中靶核酸包含肠病毒基因组的5'UTR，单纯疱疹病毒的UL29和水痘 - 带状疱疹病毒基因36 。
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公开(公告)号：US09464331B2
公开(公告)日：2016-10-11
申请号：US14130705
申请日：2012-07-06
Applicant: Maurice Exner , Luca Jacky , Yin-Peng Chen , Huong Mai , Michelle M. Tabb , Michael Aye
Inventor： Maurice Exner , Luca Jacky , Yin-Peng Chen , Huong Mai , Michelle M. Tabb , Michael Aye
CPC classification number: C12Q1/701 , C12Q1/68 , C12Q1/6846 , C12Q1/686 , C12Q1/689 , C12Q1/70 , C12Q2527/101 , C12Q2527/125
Abstract: Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction.
Abstract translation: 提供的是使用直接扩增从微生物鉴定靶核酸的存在或不存在的方法，而不提取核酸的步骤，但是保留测定提取的核酸的方法的基本相同的特异性和灵敏度。 还提供允许直接扩增样品的试剂混合物，而不需要提取核酸步骤。
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Patent Agency Ranking
公开(公告)号：US09194006B2
公开(公告)日：2015-11-24
申请号：US13543336
申请日：2012-07-06
Applicant: Maurice Exner , Luca Jacky , Yin-Peng Chen , Huong Mai , Jules Chen , Michelle M. Tabb , Michael Aye , Emberlee Eleazar
Inventor： Maurice Exner , Luca Jacky , Yin-Peng Chen , Huong Mai , Jules Chen , Michelle M. Tabb , Michael Aye , Emberlee Eleazar
CPC classification number: C12Q1/701 , C12Q1/68 , C12Q1/6846 , C12Q1/686 , C12Q1/689 , C12Q1/70 , C12Q2527/101 , C12Q2527/125
Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.
Abstract translation: 本文提供的方法是使用直接扩增从微生物鉴定靶核酸的存在或不存在，而没有提取核酸的步骤，但是保留测定提取的核酸的方法的基本上相同的特异性和灵敏度。
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公开(公告)号：US20130022963A1
公开(公告)日：2013-01-24
申请号：US13543336
申请日：2012-07-06
Applicant: MAURICE EXNER , LUCA JACKY , YIN-PENG CHEN , HUONG MAI , JULES CHEN , MICHELLE M. TABB , MICHAEL AYE , EMBERLEE ELEAZAR
Inventor： MAURICE EXNER , LUCA JACKY , YIN-PENG CHEN , HUONG MAI , JULES CHEN , MICHELLE M. TABB , MICHAEL AYE , EMBERLEE ELEAZAR
CPC classification number: C12Q1/701 , C12Q1/68 , C12Q1/6846 , C12Q1/686 , C12Q1/689 , C12Q1/70 , C12Q2527/101 , C12Q2527/125
Abstract: Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids.
Abstract translation: 本文提供的方法是使用直接扩增从微生物鉴定靶核酸的存在或不存在，而没有提取核酸的步骤，但是保留测定提取的核酸的方法的基本上相同的特异性和灵敏度。
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公开(公告)号：US20090092969A1
公开(公告)日：2009-04-09
申请号：US11869650
申请日：2007-10-09
Applicant: Michael Aye , Ming-Chou Lee , Lilly I. Kong , Michelle M. Tabb , Fan Chen , Jules Chen
Inventor： Michael Aye , Ming-Chou Lee , Lilly I. Kong , Michelle M. Tabb , Fan Chen , Jules Chen
CPC classification number: C12Q1/689 , C12Q1/6886 , C12Q2600/16
Abstract: Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.
Abstract translation: 本文公开了用于检测导致非典型肺炎的一种或多种病原体的方法和组合物。 可检测的病原体包括肺炎支原体，肺炎衣原体和嗜肺军团杆菌。
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公开(公告)号：US10465252B2
公开(公告)日：2019-11-05
申请号：US12116364
申请日：2008-05-07
Applicant: Michelle M. Tabb , Ming-Chou Lee , Lilly I. Kong , Ning Lu , Michael Aye , Fan Chen , Jules Chen
Inventor： Michelle M. Tabb , Ming-Chou Lee , Lilly I. Kong , Ning Lu , Michael Aye , Fan Chen , Jules Chen
IPC: C12Q1/689
Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
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公开(公告)号：US20090181360A1
公开(公告)日：2009-07-16
申请号：US11963699
申请日：2007-12-21
Applicant: Jules Chen , Lilly I. Kong , Ming-Chou Lee , Fan Chen , Michelle M. Tabb , Michael Aye
Inventor： Jules Chen , Lilly I. Kong , Ming-Chou Lee , Fan Chen , Michelle M. Tabb , Michael Aye
IPC: C12Q1/70
CPC classification number: C12Q1/701
Abstract: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a sample containing one or more target nucleic acids from the M gene of Influenza A, Influenza B, Respiratory Syncytial Virus A, and/or Respiratory Syncytial Virus B.
Abstract translation: 本发明一般涉及A型流感，B型流感，呼吸道合胞病毒A和呼吸道合胞病毒B的分子检测，以鉴定病毒感染患者。 因此，公开了方法和组合物以确定含有来自A型流感，B型流感，呼吸道合胞病毒A和/或呼吸道合胞病毒B的M基因的一种或多种靶核酸的样品中病毒病原体的存在或不存在。
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