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    Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease
    2.
    发明申请
    Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease 有权
    确定心血管疾病药物反应表型的脂质体方法

    公开(公告)号：US20090197242A1

    公开(公告)日：2009-08-06

    申请号：US12257957

    申请日：2008-10-24

    申请人： Rima F. Kaddurah-Daouk ,  Michelle M. Wiest ,  Steven M. Watkins ,  Rebecca A. Baillie ,  Madhumita Patnaik ,  K. Ranga Rama Krishnan ,  Richard M. Weinshilboum ,  Ronald M. Krauss

    发明人： Rima F. Kaddurah-Daouk ,  Michelle M. Wiest ,  Steven M. Watkins ,  Rebecca A. Baillie ,  Madhumita Patnaik ,  K. Ranga Rama Krishnan ,  Richard M. Weinshilboum ,  Ronald M. Krauss

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/92 ,  G01N2800/32 ,  G01N2800/52

    摘要： The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.

    摘要翻译： 本发明涉及脂质组学对于诸如心血管疾病之类的病症的他汀类药物治疗的应用。 因此，本发明尤其提供了一种通过在开始治疗方案之后从哺乳动物受试者获得样品的脂质谱，将脂质谱与对他汀类药物治疗方案的阳性或阴性反应相关的方法; 并将样品中的脂质谱与对治疗方案的阳性或阴性反应相关联。 本发明还提供了一种通过在开始治疗方案之前从哺乳动物受试者获得样品的脂质分布来将脂质谱与对他汀类药物治疗方案的阳性或阴性反应相关的方法; 并将样品中的脂质谱与对治疗方案的阳性或阴性反应相关联。