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    Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease
    2.
    发明申请
    Lipidomic Approaches to Determining Drug Response Phenotypes in Cardiovascular Disease 有权
    确定心血管疾病药物反应表型的脂质体方法

    公开(公告)号：US20090197242A1

    公开(公告)日：2009-08-06

    申请号：US12257957

    申请日：2008-10-24

    申请人： Rima F. Kaddurah-Daouk ,  Michelle M. Wiest ,  Steven M. Watkins ,  Rebecca A. Baillie ,  Madhumita Patnaik ,  K. Ranga Rama Krishnan ,  Richard M. Weinshilboum ,  Ronald M. Krauss

    发明人： Rima F. Kaddurah-Daouk ,  Michelle M. Wiest ,  Steven M. Watkins ,  Rebecca A. Baillie ,  Madhumita Patnaik ,  K. Ranga Rama Krishnan ,  Richard M. Weinshilboum ,  Ronald M. Krauss

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/92 ,  G01N2800/32 ,  G01N2800/52

    摘要： The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.

    摘要翻译： 本发明涉及脂质组学对于诸如心血管疾病之类的病症的他汀类药物治疗的应用。 因此，本发明尤其提供了一种通过在开始治疗方案之后从哺乳动物受试者获得样品的脂质谱，将脂质谱与对他汀类药物治疗方案的阳性或阴性反应相关的方法; 并将样品中的脂质谱与对治疗方案的阳性或阴性反应相关联。 本发明还提供了一种通过在开始治疗方案之前从哺乳动物受试者获得样品的脂质分布来将脂质谱与对他汀类药物治疗方案的阳性或阴性反应相关的方法; 并将样品中的脂质谱与对治疗方案的阳性或阴性反应相关联。

    METABOLIC MARKERS OF DIABETIC CONDITIONS AND METHODS OF USE THEREOF
    3.
    发明申请
    METABOLIC MARKERS OF DIABETIC CONDITIONS AND METHODS OF USE THEREOF 审中-公开
    糖尿病患者的代谢标记及其使用方法

    公开(公告)号：US20100197028A1

    公开(公告)日：2010-08-05

    申请号：US12528065

    申请日：2008-02-22

    申请人： Steven M. Watkins ,  Michelle M. Wiest

    发明人： Steven M. Watkins ,  Michelle M. Wiest

    IPC分类号： G01N33/72 ,  G01N33/92

    CPC分类号： G01N33/6893 ,  A61K38/00 ,  G01N2500/00 ,  G01N2800/042

    摘要： Novel methods for assessing the state of a diabetic condition of a subject are described, comprising determining the amount of a metabolite in a sample from a body fluid or tissue of the subject. The methods may be used, for example, in diagnosing and monitoring insulin resistance, prediabetes, or the response to a drug which alters a diabetic condition.

    摘要翻译： 描述了用于评估受试者的糖尿病状态的新方法，其包括确定来自受试者体液或组织的样品中代谢物的量。 该方法可用于例如诊断和监测胰岛素抵抗，糖尿病前期或对改变糖尿病状况的药物的反应。

    METABOLITE MARKERS FOR WEIGHT MANAGEMENT
    5.
    发明申请
    METABOLITE MARKERS FOR WEIGHT MANAGEMENT 审中-公开
    代表性管理标签

    公开(公告)号：US20090221081A1

    公开(公告)日：2009-09-03

    申请号：US12324017

    申请日：2008-11-26

    申请人： Steve M. Watkins ,  Michelle M. Wiest

    发明人： Steve M. Watkins ,  Michelle M. Wiest

    IPC分类号： G01N33/92

    CPC分类号： G01N33/6893 ,  G01N33/92 ,  G01N2800/02 ,  G01N2800/044

    摘要： The present invention provides methods of using certain metabolite markers for predicting weight development or its related conditions of a subject. The present invention also provides compositions and kits useful for detecting metabolite markers of the present invention.

    摘要翻译： 本发明提供了使用某些代谢物标记物来预测受试者的体重发育或其相关状况的方法。 本发明还提供可用于检测本发明的代谢物标记物的组合物和试剂盒。