公开(公告)号：US07482019B2

公开(公告)日：2009-01-27

申请号：US10501202

申请日：2003-01-08

申请人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

发明人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

IPC分类号： A61K9/00 ,  A61K36/06

CPC分类号： C12P19/26 ,  C08B37/003

摘要： Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized with agitation using aqueous hydroxides and/or their salts to attain a pH not lower than 7.0. The precipitated modified microcrystalline chitosan is highly pure and may be concentrated and dried according to known methods. Methods according to the invention also include methods by which an aqueous solution of chitosan is first alkalized using hydroxides and/or their salts to a pH not lower than 7.0. Then the precipitated microcrystalline chitosan is subjected to enzymatic or oxidative degradation to achieve a desired average molecular weight and polydispersity. The product is highly pure and may be concentrated and dried according to known methods.

摘要翻译： 公开了生产改性微晶壳聚糖的方法。 壳聚糖在水溶液中酶促，水解或氧化降解。 然后使用氢氧化物水溶液和/或其盐进行搅拌使壳聚糖溶液碱化以达到不低于7.0的pH。 沉淀的改性微晶壳聚糖是高纯度的，并且可以根据已知方法进行浓缩和干燥。 根据本发明的方法还包括使用氢氧化物和/或它们的盐将壳聚糖的水溶液首先碱化至pH不低于7.0的方法。 然后将沉淀的微晶壳聚糖进行酶促或氧化降解以获得所需的平均分子量和多分散性。 该产品是高纯度的，并可根据已知方法进行浓缩和干燥。

公开(公告)号：US20070129326A1

公开(公告)日：2007-06-07

申请号：US11563526

申请日：2006-11-27

申请人： Henry Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

发明人： Henry Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

IPC分类号： A61K31/722 ,  C08B37/08

CPC分类号： C12P19/26 ,  C08B37/003

摘要： Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized with agitation using aqueous hydroxides and/or their salts to attain a pH not lower than 7.0. The precipitated modified microcrystalline chitosan is highly pure and may be concentrated and dried according to known methods. Methods according to the invention also include methods by which an aqueous solution of chitosan is first alkalized using hydroxides and/or their salts to a pH not lower than 7.0. Then the precipitated microcrystalline chitosan is subjected to enzymatic or oxidative degradation to achieve a desired average molecular weight and polydispersity. The product is highly pure and may be concentrated and dried according to known methods.

公开(公告)号：US20070087997A1

公开(公告)日：2007-04-19

申请号：US11563532

申请日：2006-11-27

申请人： Henry Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

发明人： Henry Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

IPC分类号： C08B37/08 ,  A61K31/722

CPC分类号： C12P19/26 ,  C08B37/003

摘要： Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized with agitation using aqueous hydroxides and/or their salts to attain a pH not lower than 7.0. The precipitated modified microcrystalline chitosan is highly pure and may be concentrated and dried according to known methods. Methods according to the invention also include methods by which an aqueous solution of chitosan is first alkalized using hydroxides and/or their salts to a pH not lower than 7.0. Then the precipitated microcrystalline chitosan is subjected to enzymatic or oxidative degradation to achieve a desired average molecular weight and polydispersity. The product is highly pure and may be concentrated and dried according to known methods.

摘要翻译： 公开了生产改性微晶壳聚糖的方法。 壳聚糖在水溶液中酶促，水解或氧化降解。 然后使用氢氧化物水溶液和/或其盐进行搅拌使壳聚糖溶液碱化以达到不低于7.0的pH。 沉淀的改性微晶壳聚糖是高纯度的，并且可以根据已知方法进行浓缩和干燥。 根据本发明的方法还包括使用氢氧化物和/或它们的盐将壳聚糖的水溶液首先碱化至pH不低于7.0的方法。 然后将沉淀的微晶壳聚糖进行酶促或氧化降解以获得所需的平均分子量和多分散性。 该产品是高纯度的，并可根据已知方法进行浓缩和干燥。

公开(公告)号：US20070087415A1

公开(公告)日：2007-04-19

申请号：US11563507

申请日：2006-11-27

申请人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

发明人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

IPC分类号： C12P19/28 ,  C08B37/08

CPC分类号： C12P19/26 ,  C08B37/003

摘要： Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized with agitation using aqueous hydroxides and/or their salts to attain a pH not lower than 7.0. The precipitated modified microcrystalline chitosan is highly pure and may be concentrated and dried according to known methods. Methods according to the invention also include methods by which an aqueous solution of chitosan is first alkalized using hydroxides and/or their salts to a pH not lower than 7.0. Then the precipitated microcrystalline chitosan is subjected to enzymatic or oxidative degradation to achieve a desired average molecular weight and polydispersity. The product is highly pure and may be concentrated and dried according to known methods.

公开(公告)号：US20050053663A1

公开(公告)日：2005-03-10

申请号：US10501173

申请日：2003-01-08

申请人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Kinga Brzoza ,  Danuta Ciechanska ,  Maria Wisniewska-Wrona

发明人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Kinga Brzoza ,  Danuta Ciechanska ,  Maria Wisniewska-Wrona

IPC分类号： C08B37/08 ,  C08L5/08 ,  A61K9/14

CPC分类号： C08B37/003 ,  C08L5/08

摘要： Chitosan-calcium complexes of calcium (II) ions with a gel of a chitosan salt, containing not less than 0.5 wt % of the polymer with an average molecular weight not less than 10 kD, a polydispersity degree not lower than 2.0 and a deacetylation degree at least 65%. The complex is characterized by pH not higher than 6.9 and a calcium Ca (II) ions content not less than 0.1 wt % on chitosan. Methods to prepare chitosan-calcium complexes use a gel of a chitosan salt, containing not less than 0.5 wt % of the polymer. Calcium salts are introduced in the amount of at least 0.1 wt % Ca (II) on chitosan weight. The mixture is next homogenized and reacted at 10° C. during a time not shorter than 1 minute. Methods of producing a gel of chitosan salts involves subjecting a chitosan with the concentration of at least 0.5 wt % in an aqueous acidic solution to a controlled enzymatic, hydrolytic or oxidative degradation.

摘要翻译： 钙（II）离子的壳聚糖 - 钙络合物与壳聚糖盐的凝胶组成，含有不少于0.5重量％的平均分子量不小于10kD的聚合物，多分散度不低于2.0，脱乙酰度 至少65％。 该配合物的特征在于pH不高于6.9，Ca（II）离子含量对壳聚糖不低于0.1重量％。 制备壳聚糖 - 钙配合物的方法使用壳聚糖盐的凝胶，其含有不小于聚合物重量的0.5％重量。 钙盐以壳聚糖重量计至少0.1wt％Ca（II）的量引入。 接着将混合物均匀化并在10℃下反应不少于1分钟。 生产壳聚糖盐凝胶的方法包括在酸性水溶液中使浓度至少为0.5重量％的壳聚糖进行受控的酶促，水解或氧化降解。

公开(公告)号：US20050019873A1

公开(公告)日：2005-01-27

申请号：US10501202

申请日：2003-01-08

申请人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

发明人： Henryk Struszczyk ,  Antoni Niekraszewicz ,  Magdelena Kucharska ,  Alojzy Urbanowski ,  Maria Wisniewska-Wrona ,  Ewa Wesolowska ,  Danuta Ciechanska

IPC分类号： C08B37/08 ,  C12P19/26

CPC分类号： C12P19/26 ,  C08B37/003

摘要： Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized with agitation using aqueous hydroxides and/or their salts to attain a pH not lower than 7.0. The precipitated modified microcrystalline chitosan is highly pure and may be concentrated and dried according to known methods. Methods according to the invention also include methods by which an aqueous solution of chitosan is first alkalized using hydroxides and/or their salts to a pH not lower than 7.0. Then the precipitated microcrystalline chitosan is subjected to enzymatic or oxidative degradation to achieve a desired average molecular weight and polydispersity. The product is highly pure and may be concentrated and dried according to known methods.

摘要翻译： 公开了生产改性微晶壳聚糖的方法。 壳聚糖在水溶液中酶促，水解或氧化降解。 然后使用氢氧化物水溶液和/或其盐进行搅拌使壳聚糖溶液碱化以达到不低于7.0的pH。 沉淀的改性微晶壳聚糖是高纯度的，并且可以根据已知方法进行浓缩和干燥。 根据本发明的方法还包括使用氢氧化物和/或它们的盐将壳聚糖的水溶液首先碱化至pH不低于7.0的方法。 然后将沉淀的微晶壳聚糖进行酶促或氧化降解以获得所需的平均分子量和多分散性。 该产品是高纯度的，并可根据已知方法进行浓缩和干燥。