公开(公告)号：US09173888B1

公开(公告)日：2015-11-03

申请号：US14289395

申请日：2014-05-28

申请人： Elias Baydoun ,  Muhammad Iqbal Choudhary ,  Atia-tul- Wahab ,  Colin Smith ,  Martin Karam ,  Dina Farran ,  Mahwish Shafi Ahmed Khan ,  Malik Shoaib Ahmad

发明人： Elias Baydoun ,  Muhammad Iqbal Choudhary ,  Atia-tul- Wahab ,  Colin Smith ,  Martin Karam ,  Dina Farran ,  Mahwish Shafi Ahmed Khan ,  Malik Shoaib Ahmad

IPC分类号： A61K31/56 ,  A61K31/565 ,  C12Q1/18 ,  A61K31/566

CPC分类号： A61K31/565 ,  C12Q1/18 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/486

摘要： This invention provides new therapeutic potential of nandrolone or a derivative thereof, against protozoal diseases. More specifically, nandrolone or a derivative thereof exhibits anti-protozoal activity against Leishmania major. Anti-protozoal potential of nandrolone derivatives, such as compounds 1-8, can contribute in the development of effective therapies against protozoal diseases, such as leishmaniasis, trypanosomiasis, malaria, toxoplasmosis, babeosis, amoebic dysentery and lambliasis. Another aspect of the invention is a method of testing derivatives of nandrolone for anti-protozoal activity comprising growing Leishmania in the presence of the test derivative and determining the IC50 value.

摘要翻译： 本发明提供了诺乃酮或其衍生物对原生动物疾病的新的治疗潜力。 更具体地，诺龙酮或其衍生物表现出针对利什曼原虫的抗原生动物活性。 诺龙酮衍生物（例如化合物1-8）的抗原生动物潜力可以有助于开发针对原虫性疾病，例如利什曼病，锥虫病，疟疾，弓形虫病，宝宝病，阿米巴痢疾和绵羊病的有效治疗方法。 本发明的另一方面是测试nandrolone的衍生物用于抗原生动物活性的方法，其包括在测试衍生物存在下生长利什曼原虫并测定IC 50值。