公开(公告)号：US07165442B2

公开(公告)日：2007-01-23

申请号：US11006357

申请日：2004-12-07

Applicant: Robert Douglas Cryer ,  Thomas Charle Sonney ,  Manoj P. Kumar ,  William Joseph Ruprecht, III ,  Charles Joseph Waugaman ,  Matthew Lee Swedberg ,  Dennis William McAndrew ,  John Albert Mayle

Inventor： Robert Douglas Cryer ,  Thomas Charle Sonney ,  Manoj P. Kumar ,  William Joseph Ruprecht, III ,  Charles Joseph Waugaman ,  Matthew Lee Swedberg ,  Dennis William McAndrew ,  John Albert Mayle

IPC: G01M3/04

CPC classification number: G01M3/04

Abstract: Disclosed herein are methods for detecting a water leak in a locomotive engine cooling system comprising numerous components, each being a potential source of leakage of water. The method typically comprises performing at least one inspection providing an indication of a water leak from an engine cooling system of the locomotive. The step of performing at least one inspection may comprise at least one of several steps including performing a visual inspection to determine if water is leaking from a portion of the cooling system external to the engine; performing a visual inspection of exhaust of the engine to detect an indication of water vapor in the exhaust; performing a visual inspection to detect an indication of water leaking into an intake air manifold 30 of the engine; performing an engine oil analysis to detect water in the engine lubricant; reviewing a fault log history for the locomotive; and checking a level of a cooling system sight glass. The method allows for the isolation of potential sources of the water leak from one another so as to prevent false positive leak identification caused by transient water flow between the potential sources. If an engine cylinder assembly is a component identified as a potential source of the water leak during the water pressurization test, the method enables further testing to confirm leakage at such cylinder assembly, before undertaking the costly and time-consuming process of removing the cylinder assembly from the engine. Cylinder assemblies can be tested for leaks by performing an air leak test disclosed herein.

Abstract translation: 本文公开了一种用于检测机车发动机冷却系统中的漏水的方法，该机车发动机冷却系统包括许多部件，每个部件都是潜在的水泄漏源。 该方法通常包括进行至少一次检查，提供来自机车的发动机冷却系统的漏水指示。 执行至少一次检查的步骤可以包括几个步骤中的至少一个步骤，包括执行目视检查以确定水是否从发动机外部的冷却系统的一部分泄漏; 对发动机的排气进行目视检查，以检测排气中的水蒸汽的指示; 执行目视检查以检测泄漏到发动机的进气歧管30中的水的指示; 进行发动机油分析以检测发动机润滑剂中的水; 检查机车的故障记录历史; 并检查冷却系统观察窗的水平。 该方法允许将漏水的潜在来源彼此隔离，以防止由潜在源之间的瞬时水流引起的假阳性泄漏识别。 如果发动机气缸组件是在水加压试验期间被识别为潜在的漏水源的部件，则该方法能够进行进一步测试以确认在这种气缸组件处的泄漏，然后进行昂贵且耗时的除去气缸组件的过程 从发动机。 可以通过执行本文公开的空气泄漏测试来测试气缸组件的泄漏。

公开(公告)号：US08974824B2

公开(公告)日：2015-03-10

申请号：US12934296

申请日：2009-03-24

Applicant: Nagaraj Amminabavi ,  Indu Bhushan ,  Satish Kumar Jain ,  Subhash Gore ,  Gnanadeva Chalapathy Gudipati ,  Balakrishnan Chinnu ,  Subramanian Iyer ,  Manoj P Kumar ,  Rajesh S Gupta

Inventor： Nagaraj Amminabavi ,  Indu Bhushan ,  Satish Kumar Jain ,  Subhash Gore ,  Gnanadeva Chalapathy Gudipati ,  Balakrishnan Chinnu ,  Subramanian Iyer ,  Manoj P Kumar ,  Rajesh S Gupta

IPC: A61K9/14 ,  A61K33/24 ,  A61K9/20

CPC classification number: A61K33/24 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2077

Abstract: The present invention discloses stable, solid oral pharmaceutical composition comprising Lanthanum carbonate having more than 6 molecules of water per molecule of lanthanum carbonate and pharmaceutically acceptable carriers or diluents, wherein said carrier or diluent excludes monosaccharide/s or disaccharide/s, such that the composition has comparable in-vitro dissolution profile similar to that of FOSRENOL®.Also disclosed is a wet granulation process for making the same.

Abstract translation: 本发明公开了一种稳定的固体口服药物组合物，其包含每分子碳酸镧具有超过6分子水的碳酸镧和药学上可接受的载体或稀释剂，其中所述载体或稀释剂不包括单糖或二糖，使得组合物 具有与FOSRENOL®相似的体外溶出特性。 还公开了用于制造其的湿法造粒方法。

公开(公告)号：US20110020456A1

公开(公告)日：2011-01-27

申请号：US12934296

申请日：2009-03-24

Applicant: Nagaraj Amminabavi ,  Indu Bhushan ,  Kumar Jain ,  Subhash Gore ,  Gnanadeva Guidipati ,  Balakrishnan Chinnu ,  Subramanian Iyer ,  Manoj P. Kumar ,  Rajeshs Gupta

Inventor： Nagaraj Amminabavi ,  Indu Bhushan ,  Kumar Jain ,  Subhash Gore ,  Gnanadeva Guidipati ,  Balakrishnan Chinnu ,  Subramanian Iyer ,  Manoj P. Kumar ,  Rajeshs Gupta

IPC: A61K9/14 ,  A61K33/24

CPC classification number: A61K33/24 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2077

Abstract: The present invention discloses stable, solid oral pharmaceutical composition comprising Lanthanum carbonate having more than 6 molecules of water per molecule of lanthanum carbonate and pharmaceutically acceptable carriers or diluents, wherein said carrier or diluent excludes monosaccharide/s or disaccharide/s, such that the composition has comparable in-vitro dissolution profile similar to that of FOSRENOL®.Also disclosed is a wet granulation process for making the same.

Abstract translation: 本发明公开了一种稳定的固体口服药物组合物，其包含每分子碳酸镧具有超过6分子水的碳酸镧和药学上可接受的载体或稀释剂，其中所述载体或稀释剂不包括单糖或二糖，使得组合物 具有与FOSRENOL®相似的体外溶出特性。 还公开了用于制造其的湿法造粒方法。

公开(公告)号：US06931352B2

公开(公告)日：2005-08-16

申请号：US10271514

申请日：2002-10-16

Applicant: Robert Douglas Cryer ,  Charles Joseph Waugaman ,  Lance Thomas Stewart ,  Dario Patrico Escobar ,  Manoj P. Kumar ,  Laurence Richard Handler ,  Cecil M. Daniel

Inventor： Robert Douglas Cryer ,  Charles Joseph Waugaman ,  Lance Thomas Stewart ,  Dario Patrico Escobar ,  Manoj P. Kumar ,  Laurence Richard Handler ,  Cecil M. Daniel

IPC: B60H1/00 ,  F28F27/00 ,  G01N25/18 ,  G06F11/30

CPC classification number: F28F27/00 ,  B60H1/00792 ,  B60H2001/00992 ,  G01N25/18

Abstract: A system and method for monitoring the effectiveness of a heat exchange unit, which comprises at least one or more sensors for taking a plurality of temperature readings of a heated fluid, a coolant and fluids passing through the heat exchange unit. The temperature readings are transmitted and/or entered into a processor capable of comparing the temperature readings and calculating a measure of effectiveness of the heat exchange unit. The processor is in communication with a database that maintains at least one predetermined parameter limit associated with the effectiveness of the heat exchange unit. The processor analyzes the data and is also capable of generating a signal indicative of the health or condition of the heat exchange unit.

Abstract translation: 一种用于监测热交换单元的有效性的系统和方法，该系统和方法包括至少一个或多个传感器，用于对加热流体，冷却剂和通过热交换单元的流体进行多个温度读数。 温度读数被传输和/或输入到能够比较温度读数并计算热交换单元的有效性量度的处理器。 处理器与保持与热交换单元的有效性相关联的至少一个预定参数限制的数据库通信。 处理器分析数据，并且还能够产生指示热交换单元的健康或状况的信号。