公开(公告)号：US20130142792A1

公开(公告)日：2013-06-06

申请号：US13062395

申请日：2010-10-19

Applicant: Jeffrey C. Webster ,  Gregory T. Bleck ,  Madan Katragadda ,  Manoj Rajadhyaksha ,  Bernard N. Violand ,  Jo-Ann Wentland ,  Linda Marie Rothlein

Inventor： Robert Rothlein ,  Jeffrey C. Webster ,  Gregory T. Bleck ,  Madan Katragadda ,  Manoj Rajadhyaksha ,  Bernard N. Violand ,  Jo-Ann Wentland

IPC: C07K14/705 ,  C07K16/00

CPC classification number: C07K14/70503 ,  A61K39/00 ,  C07K16/00 ,  C12N15/62

Abstract: Disclosed are fusion proteins comprising a RAGE polypeptide, wherein the RAGE polypeptide comprises a fragment of a mammalian wild type RAGE peptide and at least one point mutation in the RAGE polypeptide portion of the fusion protein relative to the wild type RAGE peptide. The point mutation may remove and/or alter a glycosylation site or an enzyme cleavage site. Also disclosed are nucleic acids encoding such proteins as well as methods of using such proteins for treating RAGE-mediated pathologies.

Abstract translation: 公开了包含RAGE多肽的融合蛋白，其中RAGE多肽包含哺乳动物野生型RAGE肽的片段和融合蛋白的RAGE多肽部分相对于野生型RAGE肽的至少一个点突变。 点突变可以去除和/或改变糖基化位点或酶切割位点。 还公开了编码这种蛋白质的核酸以及使用这些蛋白质治疗RAGE介导的病理学的方法。

公开(公告)号：US06703208B1

公开(公告)日：2004-03-09

申请号：US09690637

申请日：2000-10-17

Applicant: Manoj Rajadhyaksha ,  Vijay Kumar

Inventor： Manoj Rajadhyaksha ,  Vijay Kumar

IPC: G01N3553

CPC classification number: G01N33/6893 ,  C12Q1/48 ,  G01N33/6854

Abstract: The present invention discloses a method for the detection of antibodies in celiac disease. The method comprises detecting antibodies in serum, to a combination of transglutaminase and a substrate therefor.

Abstract translation: 本发明公开了一种检测乳糜泻中抗体的方法。 该方法包括检测血清中的抗体，转谷氨酰胺酶和底物的组合。