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公开(公告)号：US20120115954A1
公开(公告)日：2012-05-10
申请号：US13352497
申请日：2012-01-18
IPC分类号： A61K31/327 , A61P17/10 , A61P31/00 , A61K31/203
CPC分类号： A61K31/192 , A61K9/0014 , A61K31/203 , A61K2300/00
摘要： Embodiments of this invention relate to a composition containing both benzoyl peroxide and a retinoid. Additionally, it relates to the treatment of acne vulgaris by applying an aqueous gel comprising BPO and a retinoid.
摘要翻译： 本发明的实施方案涉及含有过氧化苯甲酰和类视黄醇的组合物。 另外，它涉及通过应用包含BPO和类视黄醇的水性凝胶来治疗寻常痤疮。
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2.发明申请公开(公告)号：US20110009393A1
公开(公告)日：2011-01-13
申请号：US12838565
申请日：2010-07-19
申请人： Manzer Durrani , William B. Geiss , David J. Fairfax , Dmytro O. Tymoshenko , Van-Duc Le , Lisa H. Peterson
发明人： Manzer Durrani , William B. Geiss , David J. Fairfax , Dmytro O. Tymoshenko , Van-Duc Le , Lisa H. Peterson
IPC分类号： A61K31/5513 , C07D243/24 , A61P37/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P17/06 , A61P11/06 , A61P37/06
CPC分类号： A61K31/5513 , C07D243/14 , C07D243/24 , C07D401/04
摘要： The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
摘要翻译： 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供苯并二氮杂衍生物和相关化合物以及使用苯并二氮杂衍生物和相关化合物作为治疗剂来治疗与程序性细胞死亡，自身免疫，炎症，过度增殖以及 类似。
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公开(公告)号：US07759338B2
公开(公告)日：2010-07-20
申请号：US11796039
申请日：2007-04-26
申请人： Manzer Durrani , William B. Geiss , David J. Fairfax , Dmytro O. Tymoshenko , Van-Duc Le , Lisa Helen Peterson
发明人： Manzer Durrani , William B. Geiss , David J. Fairfax , Dmytro O. Tymoshenko , Van-Duc Le , Lisa Helen Peterson
IPC分类号： A61K31/5513 , A61P35/00 , C07D243/18
CPC分类号： A61K31/5513 , C07D243/14 , C07D243/24 , C07D401/04
摘要： The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
摘要翻译： 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供苯并二氮杂衍生物和相关化合物以及使用苯并二氮杂衍生物和相关化合物作为治疗剂来治疗与程序性细胞死亡，自身免疫，炎症，过度增殖以及 类似。
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4.发明申请公开(公告)号：US20080064686A1
公开(公告)日：2008-03-13
申请号：US11796039
申请日：2007-04-26
申请人： Manzer Durrani , William Geiss , David Fairfax , Dmytro Tymoshenko , Van-Duc Le , Lisa Peterson
发明人： Manzer Durrani , William Geiss , David Fairfax , Dmytro Tymoshenko , Van-Duc Le , Lisa Peterson
IPC分类号： A61K31/5513 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/04
CPC分类号： A61K31/5513 , C07D243/14 , C07D243/24 , C07D401/04
摘要： The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
摘要翻译： 本发明涉及新型化合物，其发现方法及其治疗用途。 特别地，本发明提供苯并二氮杂衍生物和相关化合物以及使用苯并二氮杂衍生物和相关化合物作为治疗剂来治疗与程序性细胞死亡，自身免疫，炎症，过度增殖以及 类似。
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公开(公告)号：US20090131521A1
公开(公告)日：2009-05-21
申请号：US12288411
申请日：2008-10-20
IPC分类号： A61K31/327 , A61K31/19 , A61P17/10
CPC分类号： A61K31/192 , A61K9/0014 , A61K31/203 , A61K2300/00
摘要： Embodiments of this invention relate to a composition containing both benzoyl peroxide and a retinoid. Additionally, it relates to the treatment of acne vulgaris by applying an aqueous gel comprising BPO and a retinoid.
摘要翻译： 本发明的实施方案涉及含有过氧化苯甲酰和类视黄醇的组合物。 另外，它涉及通过应用包含BPO和类视黄醇的水性凝胶来治疗寻常痤疮。
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公开(公告)号：US20110245238A1
公开(公告)日：2011-10-06
申请号：US13162731
申请日：2011-06-17
申请人： Manzer Durrani , William B. Geiss , David J. Fairfax , Dmytro O. Tymoshenko , Van-Duc Le , Lisa H. Peterson
发明人： Manzer Durrani , William B. Geiss , David J. Fairfax , Dmytro O. Tymoshenko , Van-Duc Le , Lisa H. Peterson
IPC分类号： A61K31/5513 , C07D413/12 , C07D243/24 , A61P35/00 , A61P11/06 , A61P17/06 , A61P37/06
CPC分类号： A61K31/5513 , C07D243/14 , C07D243/24 , C07D401/04
摘要： The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
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7.发明申请Alpha 1-Antitrypsin Compositions and Treatment Methods Using Such Compositions 审中-公开α1-抗胰蛋白酶组合物和使用这种组合物的治疗方法公开(公告)号：US20100286066A1
公开(公告)日：2010-11-11
申请号：US12714432
申请日：2010-02-26
申请人： Manzer Durrani , Harish Kumar , Timothy Krieger , Ken Kabingue , Virginia Mosher , Philip J. Barr , Ian C. Bathurst
发明人： Manzer Durrani , Harish Kumar , Timothy Krieger , Ken Kabingue , Virginia Mosher , Philip J. Barr , Ian C. Bathurst
CPC分类号： A61K9/0078 , A61K9/19 , A61K38/57 , A61K47/36 , C07K14/8125
摘要： Alpha 1-antitrypsin compositions and treatment methods using such compositions for treating a variety of pulmonary diseases are provided. The compositions generally contain AAT, a stabilizing carbohydrate such as trehalose, a surfactant such as Polysorbate 80 and an antioxidant to stabilize AAT for use as a therapeutic. The formulations can be prepared as both liquids and solids and administered by nebulization of the liquid formulation or by conversion of dry powder formulation into an aerosol.
摘要翻译： 提供了α1-抗胰蛋白酶组合物和使用这种组合物治疗各种肺部疾病的治疗方法。 组合物通常含有AAT，稳定性碳水化合物如海藻糖，表面活性剂如聚山梨酸酯80和抗氧化剂，以稳定AAT用作治疗剂。 制剂可以制备成液体和固体，并通过液体制剂的雾化或通过将干粉制剂转化成气溶胶来施用。
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8.发明申请Alpha 1-Antitrypsin Compositions and Treatment Methods Using Such Compositions 审中-公开α1-抗胰蛋白酶组合物和使用这种组合物的治疗方法公开(公告)号：US20080312136A1
公开(公告)日：2008-12-18
申请号：US10579088
申请日：2004-11-11
申请人： Manzer Durrani , Harish Kumar , Timothy Krieger , Ken Kabingue , Virginia Mosher , Philip J. Barr , Ian C. Bathurst
发明人： Manzer Durrani , Harish Kumar , Timothy Krieger , Ken Kabingue , Virginia Mosher , Philip J. Barr , Ian C. Bathurst
CPC分类号： A61K9/0078 , A61K9/19 , A61K38/57 , A61K47/36 , C07K14/8125
摘要： Alpha 1-antitrypsin compositions and treatment methods using such compositions for treating a variety of pulmonary diseases are provided. The compositions generally contain AAT, a stabilizing carbohydrate such as trehalose, a surfactant such as Polysorbate 80 and an antioxidant to stabilize AAT for use as a therapeutic. The formulations can be prepared as both liquids and solids and administered by nebulization of the liquid formulation or by conversion of dry powder formulation into an aerosol.
摘要翻译： 提供了α1-抗胰蛋白酶组合物和使用这种组合物治疗各种肺部疾病的治疗方法。 组合物通常含有AAT，稳定性碳水化合物如海藻糖，表面活性剂如聚山梨酸酯80和抗氧化剂，以稳定AAT用作治疗剂。 制剂可以制备成液体和固体，并通过液体制剂的雾化或通过将干粉制剂转化成气溶胶来施用。
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公开(公告)号：US20050271711A1
公开(公告)日：2005-12-08
申请号：US11113505
申请日：2005-04-25
申请人： Michael Lynch , Rudyard Istvan , Bart Chernow , Manzer Durrani , Robert Pan , Abel Saud , Rosa Moese
发明人： Michael Lynch , Rudyard Istvan , Bart Chernow , Manzer Durrani , Robert Pan , Abel Saud , Rosa Moese
IPC分类号： A01N25/30 , A61K9/00 , A61K9/70 , A61K31/00 , A61K31/185 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/24 , A61L2/18
CPC分类号： A61K47/12 , A01N25/30 , A61K9/0014 , A61K31/185 , A61K47/10 , A61K47/20 , A61K47/24 , A61L2/18 , A01N43/36 , A01N43/08 , A01N37/44 , A01N37/36 , A01N37/04
摘要： Therapeutic antimicrobial compositions and methods for providing enhanced immediate and residual anti-viral and antibacterial efficacy against rhinovirus, rotavirus, coronovirus, respitory syricytial virus, Gram-positive bacteria, Gram-negative bacteria and combinations thereof. More specifically, therapeutic antimicrobial compositions comprising an organic acid or organic acid mixture and a short-chain anionic surfactant having at least one of a large head group; a branched alkyl chain and an unsaturated alkyl chain, and therapeutic methods of use thereof.
摘要翻译： 用于提供针对鼻病毒，轮状病毒，冠状病毒，呼吸道感染病毒，革兰氏阳性菌，革兰氏阴性菌及其组合的立即和残留的抗病毒和抗细菌功效的治疗性抗微生物组合物和方法。 更具体地，包含有机酸或有机酸混合物的治疗性抗微生物组合物和具有大头基中的至少一个的短链阴离子表面活性剂; 支链烷基链和不饱和烷基链，以及其使用的治疗方法。
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