公开(公告)号：US07776518B2

公开(公告)日：2010-08-17

申请号：US10463867

申请日：2003-06-18

申请人： Dario C. Altieri ,  Robert M. Weiss ,  Shannon D. Smith ,  Victor A. Morris, legal representative ,  Marcia A. Wheeler ,  Janet Plescia

发明人： Dario C. Altieri ,  Robert M. Weiss ,  Shannon D. Smith ,  Marcia A. Wheeler ,  Janet Plescia

IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  G01N33/574 ,  C12P13/34 ,  C12N9/00 ,  C07H21/04 ,  C07K1/00

CPC分类号： G01N33/574 ,  C07K14/4747 ,  G01N33/57407 ,  G01N33/57434 ,  G01N33/57484 ,  G01N33/57488 ,  G01N2333/47

摘要： The present invention includes a method for diagnosing cancer and predicting recurrent cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucleic acid and a container for collecting biological fluid for testing.

摘要翻译： 本发明包括用于诊断癌症和预测复发性癌症的方法，包括检测患者生物液体中存活素的存在。 本发明还提供包含一种或多种检测存活蛋白多肽或存活蛋白核酸的试剂的试剂盒和用于收集用于测试的生物流体的容器。

公开(公告)号：US07097966B2

公开(公告)日：2006-08-29

申请号：US10042302

申请日：2002-01-11

申请人： Dario C. Altieri ,  Robert M. Weiss ,  Victor A. Morris, legal representative ,  Marcia A. Wheeler ,  Janet Plescia

发明人： Shannon D. Smith, deceased

IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/567 ,  G01N33/574 ,  C12P19/34

CPC分类号： G01N33/57488 ,  C07K14/4747 ,  G01N33/57407 ,  G01N33/57434 ,  G01N2333/47 ,  Y10S435/81

摘要： The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucleic acid and a container for collecting biological fluid for testing.

公开(公告)号：US06605447B2

公开(公告)日：2003-08-12

申请号：US09142722

申请日：1998-09-14

申请人： Robert M. Weiss ,  William C. Sessa ,  Marcia A. Wheeler ,  Shannon D. Smith

发明人： Robert M. Weiss ,  William C. Sessa ,  Marcia A. Wheeler ,  Shannon D. Smith

IPC分类号： C12Q112

CPC分类号： C12Q1/26 ,  C12Q1/527 ,  G01N33/573 ,  Y10S514/93

摘要： Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide synthase in biological samples is also provided. Detection of inducible nitric oxide synthase is useful in the diagnosis of inflammatory responses such as infections mediated by bacteria, yeast or viruses, transplant rejection, rheumatoid arthritis, interstitial cystitis and cancer.

摘要翻译： 提供了用于鉴定和监测生物样品中诱导型一氧化氮合酶水平升高或降低的方法。 还提供了用于检测生物样品中诱导型一氧化氮合酶的收集装置。 诱导型一氧化氮合酶的检测可用于诊断炎症反应，如细菌，酵母或病毒介导的感染，移植排斥反应，类风湿性关节炎，间质性膀胱炎和癌症。