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    EPR-1 proteins, polypeptides, and nucleic acid molecules encoding same
    7.
    发明授权
    EPR-1 proteins, polypeptides, and nucleic acid molecules encoding same 失效
    EPR-1蛋白质，多肽和编码相同的核酸分子

    公开(公告)号：US06072028A

    公开(公告)日：2000-06-06

    申请号：US448722

    申请日：1995-05-25

    申请人： Dario C. Altieri

    发明人： Dario C. Altieri

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P37/00 ,  C07H21/04 ,  C07K14/575 ,  C07K14/705 ,  C07K14/745 ,  C07K16/28 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  C07K16/36

    CPC分类号： C07K14/575 ,  A61K39/395 ,  C07K14/705 ,  C07K14/745 ,  C07K16/28 ,  A61K38/00 ,  C07K2317/74 ,  Y10S436/813

    摘要： A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. The DNA and amino acid residue sequences of the receptor are also described. The invention also discloses methods, sequences and vectors useful in the purification and synthesis of cellular receptors of the present invention, which receptors are identified herein as Effector Cell Protease Receptor-1 (EPR-1). Antibody compositions capable of immunoreacting with the receptor or with polypeptides containing the identified amino acid residue sequences and related therapeutic and diagnostic protocols are also described, as are polypeptides, compositions and methods relating to the inhibition of T lymphocyte proliferation using the antibodies disclosed herein. The present invention also discloses polypeptides, antibodies and compositions capable of stimulating or co-stimulating lymphocyte proliferation.

    摘要翻译： 鉴定出与凝血因子V和VIII广泛同源但不完全相同的新一类细胞受体。 还描述了受体的DNA和氨基酸残基序列。 本发明还公开了可用于纯化和合成本发明的细胞受体的方法，序列和载体，其受体在本文中被鉴定为效应细胞蛋白酶受体-1（EPR-1）。 还描述了能够与受体或含有鉴定的氨基酸残基序列和相关治疗和诊断方案的多肽免疫反应的抗体组合物，以及使用本文公开的抗体抑制T淋巴细胞增殖的多肽，组合物和方法。 本发明还公开了能刺激或共刺激淋巴细胞增殖的多肽，抗体和组合物。