公开(公告)号：US07597892B2

公开(公告)日：2009-10-06

申请号：US11827306

申请日：2007-07-11

申请人： Jan G. J. Van de Winkel ,  Marcus Antonius Van Dijk ,  Janine Schuurman ,  Arnout F. Gerritsen ,  Ole Baadsgaard ,  Jørgen Petersen

发明人： Jan G. J. Van de Winkel ,  Marcus Antonius Van Dijk ,  Janine Schuurman ,  Arnout F. Gerritsen ,  Ole Baadsgaard ,  Jørgen Petersen

IPC分类号： A61K39/395

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  Y10S514/885

摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

摘要翻译： 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。

公开(公告)号：US07585961B2

公开(公告)日：2009-09-08

申请号：US11827195

申请日：2007-07-11

申请人： Jan G. J. Van De Winkel ,  Marcus Antonius Van Dijk ,  Janine Schuurman ,  Arnout F. Gerritsen ,  Ole Baadsgaard ,  Jørgen Petersen

发明人： Jan G. J. Van De Winkel ,  Marcus Antonius Van Dijk ,  Janine Schuurman ,  Arnout F. Gerritsen ,  Ole Baadsgaard ,  Jørgen Petersen

IPC分类号： C12N15/12 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K16/24 ,  A01K2217/05 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  Y10S514/885

摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

摘要翻译： 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。

公开(公告)号：US08586041B2

公开(公告)日：2013-11-19

申请号：US12464057

申请日：2009-05-11

申请人： Jan G. J. van de Winkel ,  Marcus Antonius van Dijk ,  Edward Halk ,  Arnout F. Gerritsen ,  Jorgen Petersen ,  Ole Baadsgaard

发明人： Jan G. J. van de Winkel ,  Marcus Antonius van Dijk ,  Edward Halk ,  Arnout F. Gerritsen ,  Jorgen Petersen ,  Ole Baadsgaard

IPC分类号： A61K39/395 ,  C12P21/08 ,  C07K16/28

CPC分类号： C07K16/2863 ,  A01K2217/05 ,  A01K2217/075 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56966

摘要： Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.