-
1.发明授权Method for treating psoriasis by administering human antibodies specific for Interleukin 15 (IL-15) 有权通过施用针对白细胞介素15（IL-15）特异性的人抗体治疗牛皮癣的方法公开(公告)号：US07597892B2
公开(公告)日：2009-10-06
申请号：US11827306
申请日：2007-07-11
申请人： Jan G. J. Van de Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
发明人： Jan G. J. Van de Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
2.发明授权Nucleic acid encoding human antibodies specific for interleukin 15 (IL-15) 有权编码对白介素15（IL-15）特异性的人抗体的核酸公开(公告)号：US07585961B2
公开(公告)日：2009-09-08
申请号：US11827195
申请日：2007-07-11
申请人： Jan G. J. Van De Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
发明人： Jan G. J. Van De Winkel , Marcus Antonius Van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
公开(公告)号：US07329405B2
公开(公告)日：2008-02-12
申请号：US10374932
申请日：2003-02-26
申请人： Jan G. J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
发明人： Jan G. J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Petersen
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
-
公开(公告)号：US07247304B2
公开(公告)日：2007-07-24
申请号：US10379741
申请日：2003-03-05
申请人： Jan G. J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Peterson
发明人： Jan G. J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jørgen Peterson
IPC分类号： A61K39/395
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
公开(公告)号：US07153507B2
公开(公告)日：2006-12-26
申请号：US10226615
申请日：2002-08-23
申请人： Jan G. J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard
发明人： Jan G. J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard
IPC分类号： A61K39/395 , C12N5/12
CPC分类号： C07K16/244 , A01K2217/05 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
-
公开(公告)号：US07438907B2
公开(公告)日：2008-10-21
申请号：US10714353
申请日：2003-11-14
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
公开(公告)号：US08961968B2
公开(公告)日：2015-02-24
申请号：US13465181
申请日：2012-05-07
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jørgen Petersen , Ole Baadsgaard
IPC分类号： C07K16/28 , C07K17/00 , G01N33/577 , A61K51/10 , A61K39/395 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
-
公开(公告)号：US08182812B2
公开(公告)日：2012-05-22
申请号：US12283775
申请日：2008-09-16
申请人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
发明人： Janine Schuurman , Catharina Emanuele Gerarda Havenith , Paul Parren , Jan G. J. Van De Winkel , Denise Leah Williams , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , A61P37/02 , A61P37/08 , G01N33/53
CPC分类号： C07K16/2866 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/062 , C07K16/4258 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/56966 , G01N33/57492 , G01N33/6854 , G01N33/6869 , G01N2333/70596 , G01N2333/715 , G01N2333/7155
摘要： Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了结合并抑制人CD25的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的杂交瘤，转染瘤或非人类转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物，产生人抗体的杂交瘤和转染瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
公开(公告)号：US20080166347A1
公开(公告)日：2008-07-10
申请号：US11827306
申请日：2007-07-11
申请人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
发明人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
IPC分类号： A61K39/00
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
公开(公告)号：US20080166802A1
公开(公告)日：2008-07-10
申请号：US11827195
申请日：2007-07-11
申请人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
发明人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
-
-
-
-
-
-
-
-
-
搜索结果
40 条记录 (耗时 0.042 秒)
