公开(公告)号：US5213811A

公开(公告)日：1993-05-25

申请号：US759347

申请日：1991-09-13

申请人： Steven E. Frisbee ,  Gregg Stetsko ,  Margaret A. Lawton

发明人： Steven E. Frisbee ,  Gregg Stetsko ,  Margaret A. Lawton

IPC分类号： A61K9/50 ,  A61K9/54

CPC分类号： A61K9/5078 ,  Y10S514/962 ,  Y10S514/963 ,  Y10S514/964

摘要： Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or hydroxypropyl cellulose and a plasticizer selected from triacetin, diacetylated monoglycerides, glycerin, propylene glycol, polyethylene glycol, diethyl phthalate and triethyl citrate or a mixture of two or more thereof and a second coating of high-viscosity ethylcellulose, low-viscosity ethylcellulose, hydroxypropyl cellulose, polyvinyl acetate phthalate and a plasticizer selected from diacetylated monoglycerides and triacetin or a mixture thereof and optionally coated with additional first coating and capsules filled therewith and method of preparation thereof are disclosed.

摘要翻译： 用药物的第一次包被的糖或糖/淀粉珠，例如1,2-二氢-6-（低级烷基）-2-氧代-5-（4-吡啶基） - 烟腈（米力农），羟丙基甲基纤维素或 羟丙基纤维素和增塑剂，其选自三醋精，二乙酰化单酸甘油酯，甘油，丙二醇，聚乙二醇，邻苯二甲酸二乙酯和柠檬酸三乙酯或其两种或更多种的混合物和第二层高粘度乙基纤维素，低粘度乙基纤维素，羟丙基纤维素 ，聚乙酸乙烯酯邻苯二甲酸酯和选自二乙酰化单甘油酯和三醋精或其混合物的增塑剂，并任选地涂覆有另外的第一涂层和填充的胶囊及其制备方法。