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    Oral sustained-release drug compositions
    1.
    发明授权
    Oral sustained-release drug compositions 失效
    口服持续释放药物组合物

    公开(公告)号：US5213811A

    公开(公告)日：1993-05-25

    申请号：US759347

    申请日：1991-09-13

    申请人： Steven E. Frisbee ,  Gregg Stetsko ,  Margaret A. Lawton

    发明人： Steven E. Frisbee ,  Gregg Stetsko ,  Margaret A. Lawton

    IPC分类号： A61K9/50 ,  A61K9/54

    CPC分类号： A61K9/5078 ,  Y10S514/962 ,  Y10S514/963 ,  Y10S514/964

    摘要： Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or hydroxypropyl cellulose and a plasticizer selected from triacetin, diacetylated monoglycerides, glycerin, propylene glycol, polyethylene glycol, diethyl phthalate and triethyl citrate or a mixture of two or more thereof and a second coating of high-viscosity ethylcellulose, low-viscosity ethylcellulose, hydroxypropyl cellulose, polyvinyl acetate phthalate and a plasticizer selected from diacetylated monoglycerides and triacetin or a mixture thereof and optionally coated with additional first coating and capsules filled therewith and method of preparation thereof are disclosed.

    摘要翻译： 用药物的第一次包被的糖或糖/淀粉珠，例如1,2-二氢-6-（低级烷基）-2-氧代-5-（4-吡啶基） - 烟腈（米力农），羟丙基甲基纤维素或 羟丙基纤维素和增塑剂，其选自三醋精，二乙酰化单酸甘油酯，甘油，丙二醇，聚乙二醇，邻苯二甲酸二乙酯和柠檬酸三乙酯或其两种或更多种的混合物和第二层高粘度乙基纤维素，低粘度乙基纤维素，羟丙基纤维素 ，聚乙酸乙烯酯邻苯二甲酸酯和选自二乙酰化单甘油酯和三醋精或其混合物的增塑剂，并任选地涂覆有另外的第一涂层和填充的胶囊及其制备方法。

    PHARMACEUTICAL COMPOSITIONS
    2.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号：US20100055133A1

    公开(公告)日：2010-03-04

    申请号：US12540144

    申请日：2009-08-12

    申请人： Andrew John Duffield ,  Graham Jackson ,  Steven E. Frisbee

    发明人： Andrew John Duffield ,  Graham Jackson ,  Steven E. Frisbee

    IPC分类号： A61K39/08 ,  A61K31/435 ,  A61K31/5513 ,  A61P25/00

    CPC分类号： A61K45/06 ,  A61K9/2054 ,  A61K31/4745

    摘要： The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonlus, dystoniia and/or Tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder.

    摘要翻译： 本发明提供一种药物组合物，其包含丁苯那嗪和释放阻滞剂; 以及治疗过度运动障碍（例如亨廷顿舞蹈病，与亨廷顿舞蹈病，偏头痛，老年性舞蹈病，抽搐障碍，迟发性运动障碍，肌阵挛，肌张力障碍和/或图雷特综合征相关的舞蹈病）的方法。 该方法包括给予有效量的药物组合物一段有效治疗过度运动障碍的时间。

    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON
    5.
    发明申请
    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON 审中-公开
    基于快速溶解组合物和片剂

    公开(公告)号：US20100178353A1

    公开(公告)日：2010-07-15

    申请号：US12730339

    申请日：2010-03-24

    申请人： Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    发明人： Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    IPC分类号： A61K9/14 ,  A61K31/138 ,  A61K31/4525 ,  A61K31/437 ,  A61P25/24

    CPC分类号： A61K9/1635 ,  A61K9/0056 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/2081 ,  A61K9/5026 ,  A61K31/366 ,  A61K31/426

    摘要： The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

    摘要翻译： 本发明提供了一种组合物，其可用于制备能够在少于40秒内溶解于口中的口服剂型，而不需要常规的超级崩解剂并具有小于1％的脆性; 其中所述组合物包括液体微粒和赋形剂。 根据本发明优选的赋形剂组合物包含直接可压缩的无机盐; 纤维素衍生物或直接可压缩的无机盐和纤维素衍生物的组合。 优选地，液体颗粒和赋形剂组合的比例使得当组合物被压缩以获得硬度为20至50N的剂型时，活性成分基本保持在微球内。本发明的组合物允许 制造具有改善的硬度和脆性的口服剂量。

    Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith
    6.
    发明授权
    Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith 失效
    控制释放，低剂量阿司匹林制剂及其治疗血管闭塞性疾病的方法

    公开(公告)号：US4970081A

    公开(公告)日：1990-11-13

    申请号：US293832

    申请日：1989-01-03

    申请人： Steven E. Frisbee

    发明人： Steven E. Frisbee

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/32 ,  A61K31/60

    CPC分类号： A61K9/2081 ,  A61K31/60

    摘要： An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and disintegrants is also provided, as are processes for preparing the tablets and granules and methods for their use in the treatment of vascular occlusive diseases.

    摘要翻译： 提供了一种水性制剂，用于涂覆阿司​​匹林颗粒以提供可压缩成片剂的颗粒，并且在5-8小时内延长释放速率为5至15mg /小时的释放动力学。 涂料配方优选由丙烯酸酯/甲基丙烯酸酯共聚物，羟丙基甲基纤维素，氯化钠和滑石组成。 还提供了由包衣颗粒，填充剂颗粒，赋形剂，粘合剂和崩解剂组成的薄膜包衣片剂，以及制备片剂和颗粒的方法及其用于治疗血管闭塞性疾病的方法。

    Disintegratable microspheres
    8.
    发明授权
    Disintegratable microspheres 失效
    崩解微球

    公开(公告)号：US6086920A

    公开(公告)日：2000-07-11

    申请号：US132923

    申请日：1998-08-12

    申请人： Steven E. Frisbee ,  John Getz ,  Joseph Cascone

    发明人： Steven E. Frisbee ,  John Getz ,  Joseph Cascone

    IPC分类号： A61K9/16 ,  A61K9/14

    CPC分类号： A61K9/1617

    摘要： Microspheres which disintegrate quickly in water are composed of bio-affecting agent(s), disintegrant(s) and spheronization aid(s). The microspheres, which may have taste-masking coatings, are useful in making comestible units, such as pharmaceutical dosage forms.

    摘要翻译： 在水中快速分解的微球由生物影响剂，崩解剂和滚圆助剂组成。 可以具有掩味涂层的微球可用于制造可食用单元，例如药物剂型。

    Externally heated material processing apparatus and method
    9.
    发明授权
    Externally heated material processing apparatus and method 失效
    外加热材料加工设备及方法

    公开(公告)号：US5939120A

    公开(公告)日：1999-08-17

    申请号：US966228

    申请日：1997-11-07

    申请人： B. Arlie Bogue ,  Steven E. Frisbee ,  William F. Rutkowski

    发明人： B. Arlie Bogue ,  Steven E. Frisbee ,  William F. Rutkowski

    IPC分类号： A23G3/10 ,  D01D5/18 ,  A23G7/00 ,  A23P1/00

    CPC分类号： D01D5/18 ,  A23G3/10

    摘要： A material processing apparatus and method for processing a solid feedstock material through a melt spin process including a spinner head having a spinner head chamber defined by a parametrical processing wall through which the solid feedstock material is processed. The apparatus includes a device for rotating the spinner head about an axis of rotation to cause the feedstock material to be repelled towards and through the processing walls. A heating source separate from and exterior to the spinner head is included for heating the feedstock material to an elevated temperature to cause the melt spin processing as the feedstock material is projected through the processing wall.

    摘要翻译： 一种用于通过熔体旋转工艺处理固体原料的材料处理设备和方法，该熔融纺丝工艺包括具有由参数化处理壁限定的旋转头室的旋转头，固定原料被处理。 该装置包括用于围绕旋转轴线旋转旋转头的装置，以使得原料被朝向和通过处理壁排斥。 包括与旋转头分离和外部的加热源用于将原料材料加热到升高的温度，以在原料通过处理壁投射时引起熔体旋转加工。

    Spinner head having flow restricting inserts
    10.
    发明授权
    Spinner head having flow restricting inserts 失效
    旋转头具有流动限制插入件

    公开(公告)号：US5851454A

    公开(公告)日：1998-12-22

    申请号：US874215

    申请日：1997-06-13

    申请人： William F. Rutkowski ,  Steven E. Frisbee ,  Mesfin B. Abdi

    发明人： William F. Rutkowski ,  Steven E. Frisbee ,  Mesfin B. Abdi

    IPC分类号： A23G3/02 ,  A23G3/10 ,  A61K9/16 ,  B01J2/00 ,  B01J2/02 ,  D01D5/08 ,  D01D5/18 ,  B29C67/00

    CPC分类号： D01D5/18 ,  A23G3/10

    摘要： A spinner head is used for spinning and processing feedstock material. The spinner head includes spaced tubular heating elements which are covered by annular housing that forms a material processing wall. The annular housing contains radially spaced slots which provide a passage way for the material to be expelled from the spinner head. Each slot contains a flow restricting insert removably insertable therein. The inserts include radially extending grooves which channel the feedstock material as it exits the spinner head. The insert further include latches extending therefrom which secure the inserts in the spinner head upon rotation.

    摘要翻译： 旋转头用于纺纱和加工原料。 旋转头包括间隔开的管状加热元件，其由形成材料加工壁的环形壳体覆盖。 环形壳体包含径向隔开的狭缝，其提供用于材料从旋转头排出的通道。 每个槽包含可拆卸地插入其中的流动限制插入件。 插入件包括径向延伸的凹槽，其在原料流出旋转头时使原料流通。 插入件还包括从其延伸的闩锁，其在旋转时将插入件固定在旋转头中。