公开(公告)号：US5474764A

公开(公告)日：1995-12-12

申请号：US248865

申请日：1994-05-24

申请人： Rajesh Patel ,  Lyle Bowman ,  Margarita Vildaver ,  Raymond Chen

发明人： Rajesh Patel ,  Lyle Bowman ,  Margarita Vildaver ,  Raymond Chen

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K47/32 ,  A61K31/74 ,  A61K9/50

CPC分类号： A61K9/0048 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914

摘要： Topical ophthalmic medicament delivery system combining an aqueous ophthalmic gel suspension at a pH equal to or greater than 7.5 and an osmotic pressure of from 10 to about 400 mOsM containing a pharmaceutically effective mount of one or more ophthalmic medicaments of from about 0.05% to about 10% by weight, based on the total weight of the suspension, of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less then about 5% by weight of a cross-linking agent. The systems have a viscosity of from about 1,000 to about 30,000 centiposes prior to administration to the eye and remain a gel in the eye for a prolonged period of time allowing for the sustained release of one or medicaments such as amine containing antibiotics alone or in combination with cortiscosteroids.

摘要翻译： 局部眼科药物递送系统，其组合pH为等于或大于7.5的水性眼用凝胶悬浮液和10至约400mOsM的渗透压，所述渗透压含有约0.05％至约10％的药学上有效的一种或多种眼科药物 基于悬浮液的总重量计，通过聚合一种或多种含羧基的单烯属不饱和单体和少于约5％重量的交联剂制备的含羧基聚合物。 该系统在施用于眼睛之前具有约1,000至约30,000厘泊的粘度，并且在眼睛中保持长时间的凝胶，从而允许单独或组合的一种或多种药物如含胺抗生素的持续释放 与皮质类固醇。

公开(公告)号：US5340572A

公开(公告)日：1994-08-23

申请号：US14512

申请日：1993-02-08

申请人： Rajesh Patel ,  Lyle Bowman ,  Margarita Vildaver ,  Raymond Chen

发明人： Rajesh Patel ,  Lyle Bowman ,  Margarita Vildaver ,  Raymond Chen

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K47/32 ,  A61K31/74 ,  A61F2/14 ,  A61K9/14

CPC分类号： A61K9/0048 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914

摘要： Topical ophthalmic medicament delivery system combining an aqueous ophthalmic gel suspension at a pH equal to or greater than 7.5 and an osmotic pressure of from 10 to about 400 mOsM containing a pharmaceutically effective amount of one or more ophthalmic medicaments of from about 0.05% to about 10% by weight, based on the total weight of the suspension, of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less then about 5% by weight of a cross-linking agent. The systems have a viscosity of from about 1,000 to about 30,000 centiposes prior to administration to the eye and remain a gel in the eye for a prolonged period of time allowing for the sustained release of one or medicaments such as amine containing antibiotics alone or in combination with cortiscosteroids.

摘要翻译： 局部眼科药物递送系统将pH等于或大于7.5的pH眼用凝胶悬浮液和10至约400mOsM的渗透压组合，所述渗透压含有药学有效量的一种或多种眼用药物，其含量为约0.05％至约10 基于悬浮液的总重量计，通过聚合一种或多种含羧基的单烯属不饱和单体和少于约5％重量的交联剂制备的含羧基聚合物。 该系统在施用于眼睛之前具有约1,000至约30,000厘泊的粘度，并且在眼睛中保持长时间的凝胶，从而允许单独或组合的一种或多种药物如含胺抗生素的持续释放 与皮质类固醇。