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公开(公告)号：US5374626A
公开(公告)日：1994-12-20
申请号：US38331
申请日：1993-03-12
摘要： The present invention relates to the use as antivirals of compounds of formula: ##STR1## wherein B is a purinic or pyrimidinic heterocycle; X is oxygen or sulphur; R.sup.1 is a hydroxyl group or a hydrogen atom; R.sup.2 is a linear, branched or cyclic, alkyl group of up to twenty carbon atoms; R.sup.3 is as specified for R.sup.2 above or a hydrogen atom, a cation or a polyhydroxy group.
摘要翻译： 本发明涉及作为下式的化合物的抗病毒剂的用途：其中B是嘌呤或嘧啶杂环; X是氧或硫; R1是羟基或氢原子; R2是直链，支链或环状的，最多20个碳原子的烷基; R3如上述R2所定义或氢原子，阳离子或多羟基。
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公开(公告)号：US5017599A
公开(公告)日：1991-05-21
申请号：US485847
申请日：1990-02-21
IPC分类号： A61K31/40 , A61K31/4025 , A61P35/00 , A61P35/02 , C07D207/34 , C07D403/12 , C07D409/12 , C07D417/12 , C07D207/14
CPC分类号： C07D409/12 , C07D207/34
摘要： The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and -Het- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R.sub.1 and R.sub.2 is hydrogen and the other is an acylating moiety or R.sub.1 and R.sub.2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds.The compounds of the invention can be useful antitumor and antiviral agents.
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公开(公告)号：US5310752A
公开(公告)日：1994-05-10
申请号：US925408
申请日：1992-08-10
IPC分类号： C07D207/34 , C07D409/12 , A61K31/40 , C07D403/14
CPC分类号： C07D409/12 , C07D207/34
摘要： The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and --Het-- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R.sub.1 and R.sub.2 is hydrogen and the other is an acylating moiety or R.sub.1 and R.sub.2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds.The compounds of the invention can be useful antitumor and antiviral agents.
摘要翻译： 本发明涉及下列式的分心霉素A类似物：其中n为2,3或4; A是选自以下的任选取代的二价基团：其中Het是五原子或六原子异单环，除了吡咯; 并且其中R 1和R 2中的任一个是氢，而另一个是酰化部分或R 1和R 2都是氢或任选被取代的两个烷基，包括所述化合物的药学上可接受的盐。 本发明的化合物可以是有用的抗肿瘤剂和抗病毒剂。
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公开(公告)号：US5049579A
公开(公告)日：1991-09-17
申请号：US607339
申请日：1990-10-31
IPC分类号： C07D207/34 , C07D409/12
CPC分类号： C07D409/12 , C07D207/34
摘要： The invention relates to distamycin A analogs of the following formula ##STR1## wherein n is 2, 3 or 4; A is an optionally substituted divalent radical chosen from ##STR2## and -Het- wherein Het is a pentatomic or hexatomic heteromonocyclic ring, except pyrrole; and wherein either one of R.sub.1 and R.sub.2 is hydrogen and the other is an acylating moiety or R.sub.1 and R.sub.2 are both hydrogen or both alkyl groups optionally substituted, including the pharmaceutically acceptable salts of the said compounds.The compounds of the invention can be useful antitumor and antiviral agents.
摘要翻译： 本发明涉及下列式的分心霉素A类似物：其中n为2,3或4; A是选自以下的任选取代的二价基团：其中Het是五原子或六原子异单环，除了吡咯; 并且其中R 1和R 2中的任一个是氢，而另一个是酰化部分或R 1和R 2都是氢或任选被取代的两个烷基，包括所述化合物的药学上可接受的盐。 本发明的化合物可以是有用的抗肿瘤剂和抗病毒剂。
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