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公开(公告)号：US20100286230A1
公开(公告)日：2010-11-11
申请号：US12090426
申请日：2006-10-20
申请人： Maria del Carmen Acosta Boj , Juana Gallar Martinez , Angela Sesto Yague , Carlos Belmonte Martinez , Ana Isabel Jimenez Anton , Maria Concepcion Jimenez Gomez
发明人： Maria del Carmen Acosta Boj , Juana Gallar Martinez , Angela Sesto Yague , Carlos Belmonte Martinez , Ana Isabel Jimenez Anton , Maria Concepcion Jimenez Gomez
IPC分类号： A61K31/713 , A61K31/7105 , C07H21/02 , C12N5/00 , A61P27/02
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/14
摘要： The present invention relates to methods and compositions for the treatment and/or the prevention of conditions related to high levels of expression and/or activity of the transient receptor potential vanilloid-1 (TRPV1). Amongst others, the conditions to be treated are eye conditions such as discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses, dry eyes and diabetic retinopathy.
摘要翻译： 本发明涉及用于治疗和/或预防与瞬时受体潜在香草素-1（TRPV1）的高水平表达和/或活性有关的病症的方法和组合物。 其中，待治疗的病症是屈光手术后角膜的不适和敏感性改变等眼睛状况，使用隐形眼镜，干眼症和糖尿病性视网膜病变。
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公开(公告)号：US20080249048A1
公开(公告)日：2008-10-09
申请号：US11858579
申请日：2007-09-20
CPC分类号： A61K31/7115 , A61K31/00 , Y02A50/486
摘要： Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
摘要翻译： 公开了用于治疗肠疾病如IBD和克罗恩病的方法和组合物。 优选的组合物包括siNA。 还公开了专门靶向siNA以通过直肠内施用siNA化合物治疗肠道疾病的方法。
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公开(公告)号：US08354385B2
公开(公告)日：2013-01-15
申请号：US12090426
申请日：2006-10-20
申请人： Maria Del Carmen Acosta Boj , Juana Gallar Martinez , Angela Sesto Yague , Carlos Belmonte Martinez , Ana Isabel Jimenez Anton , Maria Concepcion Jimenez Gomez
发明人： Maria Del Carmen Acosta Boj , Juana Gallar Martinez , Angela Sesto Yague , Carlos Belmonte Martinez , Ana Isabel Jimenez Anton , Maria Concepcion Jimenez Gomez
IPC分类号： A61K48/00
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/14
摘要： The present invention relates to methods and compositions for the treatment and/or the prevention of conditions related to high levels of expression and/or activity of the transient receptor potential vanilloid-1 (TRPV1). Amongst others, the conditions to be treated are eye conditions such as discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses, dry eyes and diabetic retinopathy.
摘要翻译： 本发明涉及用于治疗和/或预防与瞬时受体潜在香草素-1（TRPV1）的高水平表达和/或活性有关的病症的方法和组合物。 其中，待治疗的病症是屈光手术后角膜的不适和敏感性改变等眼睛状况，使用隐形眼镜，干眼症和糖尿病性视网膜病变。
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