公开(公告)号：US20050014158A1

公开(公告)日：2005-01-20

申请号：US10607806

申请日：2003-06-27

Applicant: Gail Adam ,  Maria Langdown ,  Mikhail Denissenko ,  Edward Dennis ,  Charles Cantor ,  Byron Rubin

Inventor： Gail Adam ,  Maria Langdown ,  Mikhail Denissenko ,  Edward Dennis ,  Charles Cantor ,  Byron Rubin

IPC: A61B20060101 ,  A61K31/7088 ,  A61K38/46 ,  A61K45/00 ,  A61K48/00 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/44 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/564 ,  G01N33/566 ,  G01N33/68 ,  G01N33/92

CPC classification number: G01N33/566 ,  G01N33/564 ,  G01N33/6893 ,  G01N2500/20 ,  G01N2800/042

Abstract: Provided herein are methods for prognosing and diagnosing fat deposition and related disorders (e.g., obesity and non-insulin diabetes dependent mellitus (NIDDM)) in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for reducing fat deposition and related disorders, and therapeutic methods for reducing fat deposition or treating fat deposition related disorders in a subject. These embodiments are based in part upon an analysis of polymorphic variations of the nucleic acid set forth in SEQ ID NO:1.

Abstract translation: 本文提供了用于预测和诊断受试者的脂肪沉积和相关疾病（例如，肥胖和非胰岛素糖尿病依赖性细胞（NIDDM））的方法，用于实施该方法的试剂和试剂盒，用于鉴定用于减少脂肪沉积的候选治疗剂的方法 和相关疾病，以及用于减少受试者中脂肪沉积或治疗脂肪沉积相关疾病的治疗方法。 这些实施方案部分地基于对SEQ ID NO：1所示的核酸的多态变异的分析。

公开(公告)号：US20050239077A1

公开(公告)日：2005-10-27

申请号：US10608296

申请日：2003-06-27

Applicant: Gail Adam ,  Maria Langdown

Inventor： Gail Adam ,  Maria Langdown

IPC: A61B20060101 ,  C12Q1/00 ,  C12Q1/44 ,  C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: Provided herein are methods for prognosing and diagnosing fat deposition and related disorders (e.g., obesity and non-insulin diabetes dependent mellitus (NIDDM)) in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for reducing fat deposition and related disorders, and therapeutic methods for reducing fat deposition or treating fat deposition related disorders in a subject. These embodiments are based in part upon an analysis of polymorphic variations of the nucleic acid set forth in SEQ ID NO:1.

Abstract translation: 本文提供了用于预测和诊断受试者的脂肪沉积和相关疾病（例如，肥胖和非胰岛素糖尿病依赖性细胞（NIDDM））的方法，用于实施该方法的试剂和试剂盒，用于鉴定用于减少脂肪沉积的候选治疗剂的方法 和相关疾病，以及用于减少受试者中脂肪沉积或治疗脂肪沉积相关疾病的治疗方法。 这些实施方案部分地基于对SEQ ID NO：1所示的核酸的多态变异的分析。