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    METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS 审中-公开
    用于保存组织和器官的方法和组合物

    公开(公告)号：US20140030231A1

    公开(公告)日：2014-01-30

    申请号：US13695459

    申请日：2011-05-04

    申请人： Martin L. Yarmush ,  Mehmet Toner ,  Maria-Louisa Izamis ,  Timothy Antonie Berendsen ,  Robert Marius Bieganski ,  Osman Berk Usta ,  Basak Elif Uygun ,  Mustafa Korkut Uygun ,  Sinem Perk

    发明人： Martin L. Yarmush ,  Mehmet Toner ,  Maria-Louisa Izamis ,  Timothy Antonie Berendsen ,  Robert Marius Bieganski ,  Osman Berk Usta ,  Basak Elif Uygun ,  Mustafa Korkut Uygun ,  Sinem Perk

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0226 ,  G01N1/42 ,  G01N33/5091

    摘要： The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.

    摘要翻译： 本发明一般涉及用于确定用于移植和其它医疗目的的器官的活力的方法和组合物。 本发明的一个方面涉及一种通过测量能量参数来确定器官的能量水平来评估器官活力的方法，该方法是通过确定存储的细胞能量（例如，ATP水平）和/或特定的能量消耗 生存时间段 能量参数可以与参考能量参数进行比较，作为对活细胞产量和器官存活力的高度准确和可靠的预测。 本发明的另一方面涉及保存或延长器官存活时间的方法，任何组合（i）器官的保留灌注以预防缺血性损伤，（ii）器官的化学代谢抑制，例如使用代谢抑制剂， （iii）物理或环境条件下的代谢抑制，例如零度非冻结储存。