公开(公告)号：US08603766B2

公开(公告)日：2013-12-10

申请号：US13063400

申请日：2009-09-11

申请人： Marie-Lise Gougeon ,  Hela Saidi ,  Maria-Therese Melki ,  Beatrice Poirier-Beaudoin ,  Valerie Seffer

发明人： Marie-Lise Gougeon ,  Hela Saidi ,  Maria-Therese Melki ,  Beatrice Poirier-Beaudoin ,  Valerie Seffer

IPC分类号： G01N33/53 ,  G01N33/564 ,  G01N33/68

CPC分类号： G01N33/6875 ,  A61K31/00 ,  A61K31/704 ,  C12N2740/16011 ,  G01N33/56988 ,  G01N2333/16 ,  G01N2333/4703 ,  G01N2800/52

摘要： Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.

公开(公告)号：US20110229474A1

公开(公告)日：2011-09-22

申请号：US13063400

申请日：2009-09-11

申请人： Marie-Lise Gougeon ,  Hela Saidi ,  Maria-Therese Melki ,  Beatrice Poirier-Beaudoin ,  Valerie Seffer

发明人： Marie-Lise Gougeon ,  Hela Saidi ,  Maria-Therese Melki ,  Beatrice Poirier-Beaudoin ,  Valerie Seffer

IPC分类号： A61K39/395 ,  G01N33/566 ,  A61K31/704 ,  A61P31/18

CPC分类号： G01N33/6875 ,  A61K31/00 ,  A61K31/704 ,  C12N2740/16011 ,  G01N33/56988 ,  G01N2333/16 ,  G01N2333/4703 ,  G01N2800/52

摘要： Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.

摘要翻译： 用于调节人类免疫缺陷病毒（HIV）感染的组合物和方法，其涉及抑制高迁移率盒1（HMGB1）蛋白与自然杀伤（NK）细胞相互作用的能力的物质。 包含与HMGB1结合的抗体和药物如甘草酸的治疗组合物。 检测或监测涉及检测或定量生物样品中HMGB1或HMGB1特异性抗体的HIV感染的方法。