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公开(公告)号：US08603766B2
公开(公告)日：2013-12-10
申请号：US13063400
申请日：2009-09-11
申请人： Marie-Lise Gougeon , Hela Saidi , Maria-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
发明人： Marie-Lise Gougeon , Hela Saidi , Maria-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
IPC分类号： G01N33/53 , G01N33/564 , G01N33/68
CPC分类号： G01N33/6875 , A61K31/00 , A61K31/704 , C12N2740/16011 , G01N33/56988 , G01N2333/16 , G01N2333/4703 , G01N2800/52
摘要： Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
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2.发明申请MONITORING AND INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY MODULATING HMGB1 DEPENDENT TRIGGERING OF HIV-1 REPLICATION AND PERSISTENCE 有权通过调节HMGB1依赖性HIV-1复制和持续触发来监测和抑制人体免疫缺陷病毒感染公开(公告)号：US20110229474A1
公开(公告)日：2011-09-22
申请号：US13063400
申请日：2009-09-11
申请人： Marie-Lise Gougeon , Hela Saidi , Maria-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
发明人： Marie-Lise Gougeon , Hela Saidi , Maria-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
IPC分类号： A61K39/395 , G01N33/566 , A61K31/704 , A61P31/18
CPC分类号： G01N33/6875 , A61K31/00 , A61K31/704 , C12N2740/16011 , G01N33/56988 , G01N2333/16 , G01N2333/4703 , G01N2800/52
摘要： Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
摘要翻译： 用于调节人类免疫缺陷病毒（HIV）感染的组合物和方法，其涉及抑制高迁移率盒1（HMGB1）蛋白与自然杀伤（NK）细胞相互作用的能力的物质。 包含与HMGB1结合的抗体和药物如甘草酸的治疗组合物。 检测或监测涉及检测或定量生物样品中HMGB1或HMGB1特异性抗体的HIV感染的方法。
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3.发明申请HMGB1 AND ANTI-HMGB1 ANTIBODIES FOR THE PROGNOSTIC OF NEUROLOGICAL DISORDERS 有权HMGB1和抗HMGB1抗神经疾病预防的抗体公开(公告)号：US20130065221A1
公开(公告)日：2013-03-14
申请号：US13583031
申请日：2011-03-10
IPC分类号： G01N33/566 , A61B5/055
CPC分类号： G01N33/6896 , A61B5/0042 , A61B5/055 , A61B5/15 , A61B5/4029 , A61B5/4064 , A61B5/407 , A61B5/4082 , A61B5/4088 , A61B2010/0077 , G01N33/56988 , G01N33/6854 , G01N2333/16 , G01N2333/52 , G01N2333/522 , G01N2333/523 , G01N2800/28 , G01N2800/56
摘要： The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a patient, and the use of this method in the prognostic and/or diagnosis of neurological disorders. These methods are in particular applicable to the monitoring of the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV and in the prognostic and/or diagnostic of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a patient, in particular a HIV-infected patient.
摘要翻译： 本发明涉及用于定量样品中特异性的高迁移率组盒I（HMGB1）的特异性抗体的体外方法，特别是从患者获得的血清样品或脑脊液样品中的使用，以及该方法在预后中的用途 和/或神经系统疾病的诊断。 这些方法特别适用于监测已知感染艾滋病毒的受试者的人体免疫缺陷病毒（HIV）感染以及获得性免疫缺陷综合征（AIDS）进展状态的预后和/或诊断。 或艾滋病的进展状态，特别是与AIDS相关的神经障碍的进展状态或进展状态。 最后，本发明还涉及确定患者，特别是HIV感染患者的免疫缺陷或免疫激活水平的方法。
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4.发明授权HMGB1 and anti-HMGB1 antibodies for the prognostic of neurological disorders 有权HMGB1和抗HMGB1抗体用于神经系统疾病的预后公开(公告)号：US08728748B2
公开(公告)日：2014-05-20
申请号：US13583031
申请日：2011-03-10
IPC分类号： G01N33/53 , G01N33/536 , G01N33/537 , G01N33/564
CPC分类号： G01N33/6896 , A61B5/0042 , A61B5/055 , A61B5/15 , A61B5/4029 , A61B5/4064 , A61B5/407 , A61B5/4082 , A61B5/4088 , A61B2010/0077 , G01N33/56988 , G01N33/6854 , G01N2333/16 , G01N2333/52 , G01N2333/522 , G01N2333/523 , G01N2800/28 , G01N2800/56
摘要： The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a patient, and the use of this method in the prognostic and/or diagnosis of neurological disorders. These methods are in particular applicable to the monitoring of the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV and in the prognostic and/or diagnostic of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a patient, in particular a HIV-infected patient.
摘要翻译： 本发明涉及用于定量样品中特异性的高迁移率组盒I（HMGB1）的特异性抗体的体外方法，特别是从患者获得的血清样品或脑脊液样品中的使用，以及该方法在预后中的用途 和/或神经系统疾病的诊断。 这些方法特别适用于监测已知感染艾滋病毒的受试者的人体免疫缺陷病毒（HIV）感染以及获得性免疫缺陷综合征（AIDS）进展状态的预后和/或诊断。 或艾滋病的进展状态，特别是与AIDS相关的神经障碍的进展状态或进展状态。 最后，本发明还涉及确定患者，特别是HIV感染患者的免疫缺陷或免疫激活水平的方法。
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5.发明申请MONITORING AND INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY MODULATING HMGB1 DEPENDENT TRIGGERING OF HIV-1 REPLICATION AND PERSISTENCE 有权通过调节HMGB1依赖性HIV-1复制和持续触发来监测和抑制人体免疫缺陷病毒感染公开(公告)号：US20100158912A1
公开(公告)日：2010-06-24
申请号：US12558111
申请日：2009-09-11
申请人： Marie-Lise Gougeon , Hela Saidi , Marie-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
发明人： Marie-Lise Gougeon , Hela Saidi , Marie-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
IPC分类号： A61K39/395 , C07K16/18 , C07K16/00 , C07K14/00 , A61P31/18 , A61K38/16 , G01N33/567 , G01N33/53
CPC分类号： G01N33/6875 , A61K31/00 , A61K31/704 , C12N2740/16011 , G01N33/56988 , G01N2333/16 , G01N2333/4703 , G01N2800/52
摘要： Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
摘要翻译： 用于调节人类免疫缺陷病毒（HIV）感染的组合物和方法，其涉及抑制高迁移率盒1（HMGB1）蛋白与自然杀伤（NK）细胞相互作用的能力的物质。 包含与HMGB1结合的抗体和药物如甘草酸的治疗组合物。 检测或监测涉及检测或定量生物样品中HMGB1或HMGB1特异性抗体的HIV感染的方法。
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