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    Fusion protein construct and method for inducing HIV-specific serum IgG and secretory IgA antibodies in-vivo
    2.
    发明授权
    Fusion protein construct and method for inducing HIV-specific serum IgG and secretory IgA antibodies in-vivo 失效
    融合蛋白构建体和体内诱导HIV特异性血清IgG和分泌型IgA抗体的方法

    公开(公告)号：US07262270B2

    公开(公告)日：2007-08-28

    申请号：US10655667

    申请日：2003-09-05

    申请人： Winfried Weissenhorn ,  David Prashker, legal representative ,  Nicholas Mantis ,  Marian R. Neutra ,  Pamela Kozlowski

    发明人： Don Wiley, deceased

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  C07K1/00

    CPC分类号： C07K14/005 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/545 ,  C07K2319/00 ,  C12N2740/16122 ,  C12N2760/16022 ,  Y10S530/826

    摘要： The present invention provides a fusion protein construct (gp41HA) consisting of the ectodomain of the HIV-1IIIB envelope glycoprotein gp41 fused to a fragment of the influenza virus HA2 hemagglutinin protein. Immunization in-vivo via an intraperitoneal prime followed by intranasal or intragastric boosts with gp41HA induces high concentrations of serum IgG antibodies and fecal IgA antibodies that reacted with gp41 in HIV-1IIIB viral lysate and are cross-reactive with gp41 in HIV-1MN lysate. Followup analyses by indirect immunofluorescence showed that both serum IgG and fecal IgA recognized human peripheral blood mononuclear cells infected with either syncytium-inducing (SI) or non-syncytium-inducing (NSI) North American HIV-1 field isolates, but not uninfected cells.

    摘要翻译： 本发明提供了融合蛋白质构建体（gp41HA），其由与流感病毒HA2血凝素蛋白片段融合的HIV-1 IIIB包膜糖蛋白gp41的胞外域组成。 通过腹膜内注射进行体内免疫，随后用gp41HA进行鼻内或胃内加压，诱导高浓度的血清IgG抗体和与HIV-1 IIIB III病毒裂解物中的gp41反应的血清IgG抗体和粪便IgA抗体，并且是交叉反应性 在HIV-1 MN溶解产物中具有gp41。 通过间接免疫荧光进行的随访分析显示，血清IgG和粪便IgA均识别出感染合胞体诱导（SI）或非合胞体诱导（NSI）北美HIV-1场分离株但不是未感染细胞的人外周血单核细胞。

    Spatially aligned conjugated composition having a thioether bond linkage
    3.
    发明授权
    Spatially aligned conjugated composition having a thioether bond linkage 失效
    具有硫醚键的空间取向的共轭组合物

    公开(公告)号：US6086881A

    公开(公告)日：2000-07-11

    申请号：US79374

    申请日：1998-05-15

    申请人： Andreas Frey ,  Marian R. Neutra ,  Frank A. Robey

    发明人： Andreas Frey ,  Marian R. Neutra ,  Frank A. Robey

    IPC分类号： A61K9/16 ,  A61K9/51 ,  A61K39/385 ,  A61P37/04 ,  C07K14/16 ,  A61K38/00 ,  A61M36/14 ,  C07K5/00

    CPC分类号： C07K14/005 ,  A61K39/385 ,  A61K2039/55505 ,  A61K2039/60 ,  A61K2039/627 ,  C12N2740/16122

    摘要： The present invention is a spatially aligned conjugated composition which comprises at least one chemically modified substance which is immunologically representative of a prechosen infectious agent and provides a chemical constituent for entering into and forming a thioether bond; a plurality of chemically substituted metallic oxide particles which range from about 10-10,000 nanometers and are able to enter into a thioether bond and covalent linkage; and at least one thioether bond and linkage joining the metallic oxide particles in a controlled and spatially aligned manner to the antigen or hapten. The conjugated composition may be alternatively employed as an immunogen; as a vaccine; as a diagnostic tool and reactant; and as an analytical material suitable for testing the pharmacological activity of new compounds.

    摘要翻译： 本发明是空间取向的共轭组合物，其包含至少一种化学修饰的物质，其具有免疫学上代表预先感染的物质并提供用于进入和形成硫醚键的化学成分; 多个化学取代的金属氧化物颗粒，其范围为约10-10,000纳米，并且能够进入硫醚键和共价键; 以及至少一个硫醚键和连接金属氧化物颗粒的控制和空间对准方式与抗原或半抗原的连接。 共轭组合物可以替代地用作免疫原; 作为疫苗; 作为诊断工具和反应物; 并且作为适用于测试新化合物的药理活性的分析物质。