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公开(公告)号：US12115169B2
公开(公告)日：2024-10-15
申请号：US18432492
申请日：2024-02-05
发明人： Joseph Hulihan , Alex Aimetti , Scott Braunstein
CPC分类号： A61K31/57 , A61K31/658 , A61P25/08
摘要： The disclosure to methods for treating tuberous sclerosis complex and epilepsy disorders comprising administering to a subject in need thereof a therapeutically effective amount of ganaxolone or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20230321117A1
公开(公告)日：2023-10-12
申请号：US18328996
申请日：2023-06-05
发明人： Alex Aimetti , Joseph HULIHAN
CPC分类号： A61K31/57 , A61K9/4808 , A61B5/291 , A61P25/08 , A61K9/0053
摘要： The disclosure to methods for treating seizure or an epilepsy disorder comprising administering to a subject in need thereof a therapeutically effective amount of ganaxolone or a pharmaceutically acceptable salt thereof.
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3.发明申请Stable Corticosteroid Nanoparticulate Formulations and Methods for the Making and Use thereof 有权稳定的皮质类固醇纳米颗粒制剂及其制备和使用方法公开(公告)号：US20130243830A1
公开(公告)日：2013-09-19
申请号：US13887673
申请日：2013-05-06
发明人： Kenneth Shaw , Mingbao Zhang
CPC分类号： A61K9/145 , A61K9/007 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/1623 , A61K9/1652 , A61K9/2886 , A61K9/5078 , A61K31/58 , A61K47/14 , A61K47/6949 , B82Y5/00 , C07J71/00 , Y10S977/773 , Y10S977/906
摘要： Disclosed are stable corticosteroid nanoparticulate formulations, methods of making and therapeutic uses thereof.
摘要翻译： 公开了稳定的皮质类固醇纳米颗粒制剂，其制备方法及其治疗用途。
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公开(公告)号：US20240245709A1
公开(公告)日：2024-07-25
申请号：US18625718
申请日：2024-04-03
IPC分类号： A61K31/57 , A61K9/00 , A61K31/724
CPC分类号： A61K31/57 , A61K9/0019 , A61K31/724
摘要： This invention relates to methods for treating established status epilepticus (ESE) by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides ESE suppression and continued suppression of ESE.
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公开(公告)号：US20240173336A1
公开(公告)日：2024-05-30
申请号：US18432492
申请日：2024-02-05
发明人： Joseph HULIHAN , Alex AIMETTI , Scott BRAUNSTEIN
CPC分类号： A61K31/57 , A61K31/658 , A61P25/08
摘要： The disclosure to methods for treating tuberous sclerosis complex and epilepsy disorders comprising administering to a subject in need thereof a therapeutically effective amount of ganaxolone or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11266662B2
公开(公告)日：2022-03-08
申请号：US16705541
申请日：2019-12-06
摘要： Uses of ganaxolone in prophylaxis and treatment of postpartum depression are described. A dose of ganaxolone is administered to a female suffering from postpartum depression or at risk of developing postpartum depression in an amount and at a rate sufficient to alleviate at least one symptom of postpartum depression in the female.
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公开(公告)号：US11110100B2
公开(公告)日：2021-09-07
申请号：US17186569
申请日：2021-02-26
发明人： David Czekai , Maciej Gasior , Lorianne Masuoka , Julia Tsai , Joseph Hulihan , Alex Aimetti
IPC分类号： A61K31/573 , A61P25/08 , A61K9/00
摘要： This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.
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公开(公告)号：US20210186987A1
公开(公告)日：2021-06-24
申请号：US17186569
申请日：2021-02-26
发明人： David CZEKAI , Maciej GASIOR , Lorianne MASUOKA , Julia TSAI , Joseph HULIHAN , Alex AIMETTI
IPC分类号： A61K31/573 , A61K9/00 , A61P25/08
摘要： This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.
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公开(公告)号：US20200289530A1
公开(公告)日：2020-09-17
申请号：US16829661
申请日：2020-03-25
IPC分类号： A61K31/573 , C07J7/00 , A61K45/06 , A61K31/5513 , A61K47/36 , A61K47/69 , A61K47/32 , A61K47/10 , A61K9/00 , C08B37/16 , A61K47/38 , A61K31/57 , A61K9/107
摘要： The disclosure provides a method of treating a patient having postpartum depression, premenstrual dysphoric disorder, menopausal depression, or delirium tremens comprising administering an effective amount of an injectable neurosteroid formulation to the patient. In certain embodiments the injectable neurosteroid formulation is an injectable ganaxolone formulation. Two types of injectable neurosteroid formulations may be used in the disclosed methods. The first such formulation is an injectable formulation containing ganaxolone and sulfobutyl ether β-cyclodextrin in a 1:1 inclusion complex. The second such formulation is an injectable neurossteroid formulation comprising a neurosteroid, preferably ganaxolone, but which may be a neurosteroid selected from allopregnanolone, ganaxolone, alphaxalone, alphadolone, hydroxydione, minaxolone, pregnanolone, tetrahydrocorticosterone, and combinations of the foregoing; a surface stabilizer selected from hydroxyl ethyl starch, dextran, and povidone; and a surfactant.
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公开(公告)号：US10391105B2
公开(公告)日：2019-08-27
申请号：US15700314
申请日：2017-09-11
IPC分类号： A61K31/56 , A61K31/573 , C07J7/00 , A61K31/721 , A61K31/718
摘要： The disclosure provides a method of treating a patient having postpartum depression, premenstrual dysphoric disorder, menopausal depression, or delirium tremens comprising administering an effective amount of an injectable neurosteroid formulation to the patient. In certain embodiments the injectable neurosteroid formulation is an injectable ganaxolone formulation. Two types of injectable neurosteroid formulations may be used in the disclosed methods. The first such formulation is an injectable formulation containing ganaxolone and sulfobutyl ether β-cyclodextrin in a 1:1 inclusion complex. The second such formulation is an injectable neurossteroid formulation comprising a neurosteroid, preferably ganaxolone, but which may be a neurosteroid selected from allopregnanolone, ganaxolone, alphaxalone, alphadolone, hydroxydione, minaxolone, pregnanolone, tetrahydrocorticosterone, and combinations of the foregoing; a surface stabilizer selected from hydroxyl ethyl starch, dextran, and povidone; and a surfactant.
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