-
公开(公告)号：US20080096828A1
公开(公告)日：2008-04-24
申请号：US11636206
申请日：2006-12-07
申请人： Simon Shaw , Gary Ashley , Mark Burlingame
发明人： Simon Shaw , Gary Ashley , Mark Burlingame
IPC分类号： A61K31/7048 , A61P11/00 , A61P17/00 , C07H17/08
CPC分类号： C07D405/14
摘要： 15-fluoroketolides of the formula having improved activity and safety, compositions comprising them, and methods for their preparation and use in the treatment of bacterial infections.
摘要翻译： 具有改善的活性和安全性的式的15-氟代内酯类，包含它们的组合物，及其制备和用于治疗细菌感染的方法。
-
2.发明授权公开(公告)号：US07342124B2
公开(公告)日：2008-03-11
申请号：US10817532
申请日：2004-04-02
申请人： David C. Myles , Mark Burlingame , Simon James Shaw , Kurt F. Sundermann , Brian Scott Freeze , Ignació Brouard Martin , Tomoyasu Hirose , Amos B. Smith, III
发明人： David C. Myles , Mark Burlingame , Simon James Shaw , Kurt F. Sundermann , Brian Scott Freeze , Ignació Brouard Martin , Tomoyasu Hirose , Amos B. Smith, III
CPC分类号： C07D309/30 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
-
3.发明申请公开(公告)号：US20050049414A1
公开(公告)日：2005-03-03
申请号：US10817532
申请日：2004-04-02
申请人： David Myles , Mark Burlingame , Simon Shaw , Kurt Sundermann , Brian Freeze , Ignacio Martin , Tomoyasu Hirose , Amos Smith
发明人： David Myles , Mark Burlingame , Simon Shaw , Kurt Sundermann , Brian Freeze , Ignacio Martin , Tomoyasu Hirose , Amos Smith
IPC分类号： C07D20060101 , C07D309/10 , C07D309/30 , C07D309/32 , C07F9/28
CPC分类号： C07D309/30 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
-
公开(公告)号：US20060270616A1
公开(公告)日：2006-11-30
申请号：US11416519
申请日：2006-05-02
申请人： Yaoquan Liu , Christopher Carreras , David Myles , Yong Li , Simon Shaw , Hong Fu , Yue Chen , Hao Zheng , Yandong Li , Mark Burlingame
发明人： Yaoquan Liu , Christopher Carreras , David Myles , Yong Li , Simon Shaw , Hong Fu , Yue Chen , Hao Zheng , Yandong Li , Mark Burlingame
IPC分类号： A61K31/7048 , C07H17/08
CPC分类号： C07H17/08
摘要： Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.
摘要翻译： 具有式（I）结构的化合物其中R A，R B，R C，R D，D， R E和R F如本文所定义，可用作促动力剂。
-
公开(公告)号：US07090109B2
公开(公告)日：2006-08-15
申请号：US11023186
申请日：2004-12-27
申请人： Mark Burlingame , Cory Burlingame
发明人： Mark Burlingame , Cory Burlingame
IPC分类号： B25C7/00
CPC分类号： B25C5/1693
摘要： The invention comprises a staple gun with highly compact accessory apparatus for attaching a planar tab or label to a fixing surface. The accessory has a housing and a positioning and indexing assembly associated with the housing which is operable to feed and hold a tab or label between the staple gun head and fixing surface, thereby allowing single-handed fixing of a label or tab to a fixing surface. The apparatus can include a roller assembly, staple gun and accessory apparatus or have all components integrated into the construction of a staple gun apparatus. Preferably, the apparatus is mated with a tab or label holding magazine. Some exemplary embodiments of the invention are suitable for securing protective covering to lumber product and may be configured for rectangular polyolefin tabs measuring approximately 0.035 inch thick and 1.0 inches by 2.0 inches.
摘要翻译： 本发明包括具有高度紧凑的附件装置的钉枪，用于将平面突片或标签附接到固定表面。 附件具有壳体和与壳体相关联的定位和分度组件，其可操作以在钉枪头和固定表面之间进给和保持突片或标签，从而允许将标签或突片单手固定到固定表面 。 该装置可以包括辊组件，钉枪和附件装置，或者将所有部件集成到钉枪装置的构造中。 优选地，该装置与标签或标签保持盒配合。 本发明的一些示例性实施例适用于将保护性覆盖物固定到木材产品上，并且可以被配置为测量大约0.035英寸厚和1.0英寸×2.0英寸的矩形聚烯烃片。
-
公开(公告)号：US20050145668A1
公开(公告)日：2005-07-07
申请号：US11023186
申请日：2004-12-27
申请人： Mark Burlingame , Cory Burlingame
发明人： Mark Burlingame , Cory Burlingame
CPC分类号： B25C5/1693
摘要： The invention comprises a staple gun with highly compact accessory apparatus for attaching a planar tab or label to a fixing surface. The accessory has a housing and a positioning and indexing assembly associated with the housing which is operable to feed and hold a tab or label between the staple gun head and fixing surface, thereby allowing single-handed fixing of a label or tab to a fixing surface. The apparatus can include a roller assembly, staple gun and accessory apparatus or have all components integrated into the construction of a staple gun apparatus. Preferably, the apparatus is mated with a tab or label holding magazine. Some exemplary embodiments of the invention are suitable for securing protective covering to lumber product and may be configured for rectangular polyolefin tabs measuring approximately 0.035 inch thick and 1.0 inches by 2.0 inches.
摘要翻译： 本发明包括具有高度紧凑的附件装置的钉枪，用于将平面突片或标签附接到固定表面。 附件具有壳体和与壳体相关联的定位和分度组件，其可操作以在钉枪头和固定表面之间进给和保持突片或标签，从而允许将标签或突片单手固定到固定表面 。 该装置可以包括辊组件，钉枪和附件装置，或者将所有部件集成到钉枪装置的构造中。 优选地，该装置与标签或标签保持盒配合。 本发明的一些示例性实施例适用于将保护性覆盖物固定到木材产品上，并且可以被配置为测量大约0.035英寸厚和1.0英寸×2.0英寸的矩形聚烯烃片。
-
公开(公告)号：US06750205B2
公开(公告)日：2004-06-15
申请号：US10409429
申请日：2003-04-07
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR9, where R9 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R10 and R11 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl alkynylaryl or R2 and R3 together form a cycloalkyl or a cycloaryl moiety; R4 is hydrogen or methyl; R5 is hydrogen, hydroxyl, oxo, or together with R6 and the carbons to which they are attached form a cyclic carbonate; R6 is hydrogen, hydroxyl, OR12 where R12 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate; R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; R8 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, x is a single or a double bond.
摘要翻译： 本发明提供下式的新型大环内酯化合物，其中R是羟基或甲氧基; R 1选自氢，羟基，卤素，NH 2，OR 9，其中R 9是C 1 -C 10 烷基，C 2 -C 10烯基，C 2 -C 10炔基，芳基或杂芳基，R 10和R 11各自独立地为氢，C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基或芳基; R 2和R 3各自独立地选自氢，C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，芳基，烷基芳基，烯基芳基炔基芳基或R 2和R 3一起 形成环烷基或环芳基部分; R 4是氢或甲基; R 5是氢，羟基，氧代或与R 6一起，并且它们连接的碳形成环状碳酸酯; 其中R 12是C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，或与R 5一起形成的碳原子和它们所连接的碳原子形成环状 碳酸酯; R 7是甲基，C 3 -C 10烷基，C 2 -C 10烯基，C 2 -C 10 炔基，烷基芳基，烯基芳基，炔基芳基，酰氨基烷基芳基，酰氨基烯基芳基或酰胺基炔基芳基; R 8是C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，烷基芳基，链烯基芳基，炔基芳基，酰氨基烷基芳基，酰胺基烯基芳基或酰胺基炔基芳基; x是单键或双键。
-
公开(公告)号：US06834731B2
公开(公告)日：2004-12-28
申请号：US10635766
申请日：2003-08-06
申请人： Mark Burlingame , Cory Burlingame
发明人： Mark Burlingame , Cory Burlingame
IPC分类号： B25C700
CPC分类号： B25C5/1693
摘要： The invention comprises a staple gun with highly compact accessory apparatus for attaching a planar tab or label to a fixing surface. The accessory has a housing and a positioning and indexing assembly associated with the housing which is operable to feed and hold a tab or label between the staple gun head and fixing surface, thereby allowing single-handed fixing of a label or tab to a fixing surface. The apparatus can include a roller assembly, staple gun and accessory apparatus or have all components integrated into the construction of a staple gun apparatus. Preferably, the apparatus is mated with a tab or label holding magazine. Some exemplary embodiments of the invention are suitable for securing protective covering to lumber product and may be configured for rectangular polyolefin tabs measuring approximately 0.035 inch thick and 1.0 inches by 2.0 inches.
摘要翻译： 本发明包括具有高度紧凑的附件装置的钉枪，用于将平面突片或标签附接到固定表面。 附件具有壳体和与壳体相关联的定位和分度组件，其可操作以在钉枪头和固定表面之间输送和保持突片或标签，从而允许将标签或突片单手固定到固定表面 。 该装置可以包括辊组件，钉枪和附件装置，或者将所有部件集成到钉枪装置的构造中。 优选地，该装置与标签或标签保持盒配合。 本发明的一些示例性实施例适用于将保护性覆盖物固定到木材产品上，并且可以被配置为测量大约0.035英寸厚和1.0英寸×2.0英寸的矩形聚烯烃片。
-
公开(公告)号：US06562795B2
公开(公告)日：2003-05-13
申请号：US09788314
申请日：2001-02-15
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： The present invention provides novel macrolide compounds of the formulas wherein: R is hydroxyl or methoxy; R1 is selected from the group consisting of hydrogen, hydroxyl, halide, NH2, OR9, where R9 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl or heteroaryl and R10 and R11 are each independently hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or aryl; R2 and R3 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, alkylaryl, alkenylaryl, alkynylaryl or R2 and R3 together form a cycloalkyl or a cycloaryl moiety; R4 is hydrogen or methyl; R5 is hydrogen, hydroxyl, oxo, or together with R6 and the carbons to which they are attached form a cyclic carbonate; R6 is hydrogen, hydroxyl, OR12 where R12 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, or together with R5 and the carbons to which they are attached form a cyclic carbonate; R7 is methyl, C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; R8 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, alkylaryl, alkenylaryl, alkynylaryl, amidoalkylaryl, amidoalkenylaryl, or amidoalkynylaryl; and, x is a single or a double bond.
摘要翻译： 本发明提供下式的新型大环内酯化合物，其中R为羟基或甲氧基; R 1选自氢，羟基，卤素，NH 2，OR 9，其中R 9为C 1 -C 10烷基，C 2 -C 10烯基， C10炔基，芳基或杂芳基，R10和R11各自独立地为氢，C1-C10烷基，C2-C10烯基，C2-C10炔基或芳基; R2和R3各自独立地选自氢，C1-C10 烷基，C 2 -C 10烯基，C 2 -C 10炔基，芳基，烷基芳基，烯基芳基，炔基芳基或R 2和R 3一起形成环烷基或环芳基部分; R 4是氢或甲基; R 5是氢，羟基，氧代或与R 6一起 并且与它们相连的碳原子形成环状碳酸酯; R 6是氢，羟基，OR 12，其中R 12是C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，或与R 5和它们所连接的碳一起 形成环状碳酸酯; R 7是甲基，C 3 -C 10烷基，C 2 -C 10烯基，C 2 -C 10炔基，烷基芳基，链烯基芳基 ，芳基芳基，酰氨基烷基芳基，酰胺基烯基芳基或酰氨基炔基芳基; R8是C1-C10烷基，C2-C10烯基，C2-C10炔基，烷基芳基，烯基芳基，炔基芳基，酰氨基烷基芳基，酰氨基烯基芳基或酰胺基炔基芳基; x是单键或双键。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.016 秒)
