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    Pramipexole once-daily dosage form
    2.
    发明申请
    Pramipexole once-daily dosage form 有权
    普拉克索每日一次剂型

    公开(公告)号：US20050175691A1

    公开(公告)日：2005-08-11

    申请号：US10626275

    申请日：2003-07-24

    申请人： Ernest Lee ,  Gerard Bredael ,  John Baldwin ,  Steven Cox ,  Mark Heintz

    发明人： Ernest Lee ,  Gerard Bredael ,  John Baldwin ,  Steven Cox ,  Mark Heintz

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4745 ,  A61P25/16 ,  A61P43/00

    CPC分类号： A61K31/428 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/28 ,  A61K9/2866 ,  A61K31/4745

    摘要： An orally deliverable pharmaceutical composition comprises a therapeutically effective amount of pramipexole or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, said composition exhibiting at least one of (a) an in vitro release profile wherein on average no more than about 20% of the pramipexole is dissolved within 2 hours after placement of the composition in a standard dissolution test; and (b) an in vivo pramipexole absorption profile following single dose administration to healthy adult humans wherein the time to reach a mean of 20% absorption is greater than about 2 hours and/or the time to reach a mean of 40% absorption is greater than about 4 hours. The composition is useful for oral administration, not more than once daily, to a subject having a condition or disorder for which a dopamine receptor agonist is indicated.

    摘要翻译： 可口服递送的药物组合物包含治疗有效量的普拉克索或其药学上可接受的盐和至少一种药学上可接受的赋形剂，所述组合物显示以下至少一种：（a）体外释放曲线，其平均不超过约20％ 的普拉克索在将组合物放入标准溶出试验后2小时内溶解; 并且（b）对健康成年人单剂量给药后的体内普拉克索吸收曲线，其中达到平均20％吸收的时间大于约2小时和/或达到平均40％吸收的时间更大 超过约4小时。 该组合物可用于每天不超过一次给予具有指示多巴胺受体激动剂的病症或病症的受试者。

    Tool-less adjustable foot assembly for a power hand tool
    3.
    发明授权
    Tool-less adjustable foot assembly for a power hand tool 有权
    用于电动手动工具的无工具可调脚组件

    公开(公告)号：US07503121B2

    公开(公告)日：2009-03-17

    申请号：US11169826

    申请日：2005-06-29

    申请人： Dennis Powell ,  Mark Heintz ,  Ivan Guo ,  Sean Gallagher ,  Richard LaSota ,  Richard Sutkowski

    发明人： Dennis Powell ,  Mark Heintz ,  Ivan Guo ,  Sean Gallagher ,  Richard LaSota ,  Richard Sutkowski

    IPC分类号： B23D49/10 ,  B07B19/09

    CPC分类号： B23D49/167 ,  B23D51/02 ,  Y10T83/68 ,  Y10T83/9481

    摘要： A preferred embodiment of the present invention comprises a foot assembly for a power hand tool such as a jigsaw that has an angularly adjustable support foot with a generally flat bottom, at least two spaced apart supports connected to the support foot, an elongated rod extends through apertures in the supports in a configuration that permits limited sliding movement and the angular adjusting movement of the support foot relative to the hand tool, a retainer member associated with the hand tool that selectively engages one of the supports to lock the support foot at predetermined angular positions, and a spring biases the retainer member toward engagement with the support. A second embodiment includes a removable transparent plate that attaches to the support foot and has a faux laser line for a cutting aid.

    摘要翻译： 本发明的一个优选实施例包括用于诸如拼图的动力手动工具的脚组件，其具有角度可调节的支撑脚，其具有大致平坦的底部，连接到支撑脚的至少两个间隔开的支撑件，细长杆延伸穿过 支撑件中的孔允许有限的滑动运动和支撑脚相对于手动工具的角度调节运动;与手动工具相关联的保持构件，其选择性地接合其中一个支撑件，以将支撑脚锁定在预定角度 并且弹簧偏压保持构件以与支撑件接合。 第二实施例包括附接到支撑脚并且具有用于切削辅助件的人造激光线的可拆卸透明板。

    Tool-less adjustable foot assembly for a power hand tool
    5.
    发明申请
    Tool-less adjustable foot assembly for a power hand tool 有权
    用于电动手动工具的无工具可调脚组件

    公开(公告)号：US20070000368A1

    公开(公告)日：2007-01-04

    申请号：US11169826

    申请日：2005-06-29

    申请人： Dennis Powell ,  Mark Heintz ,  Ivan Guo ,  Sean Gallagher ,  Richard LaSota ,  Richard Sutkowski

    发明人： Dennis Powell ,  Mark Heintz ,  Ivan Guo ,  Sean Gallagher ,  Richard LaSota ,  Richard Sutkowski

    IPC分类号： B23D51/10 ,  B27B21/00

    CPC分类号： B23D49/167 ,  B23D51/02 ,  Y10T83/68 ,  Y10T83/9481

    摘要： A preferred embodiment of the present invention comprises a foot assembly for a power hand tool such as a jigsaw that has an angularly adjustable support foot with a generally flat bottom, at least two spaced apart supports connected to the support foot, an elongated rod extends through apertures in the supports in a configuration that permits limited sliding movement and the angular adjusting movement of the support foot relative to the hand tool, a retainer member associated with the hand tool that selectively engages one of the supports to lock the support foot at predetermined angular positions, and a spring biases the retainer member toward engagement with the support. A second embodiment includes a removable transparent plate that attaches to the support foot and has a faux laser line for a cutting aid

    摘要翻译： 本发明的一个优选实施例包括用于诸如拼图的动力手动工具的脚组件，其具有角度可调节的支撑脚，其具有大致平坦的底部，连接到支撑脚的至少两个间隔开的支撑件，细长杆延伸穿过 支撑件中的孔允许有限的滑动运动和支撑脚相对于手动工具的角度调节运动;与手动工具相关联的保持构件，其选择性地接合其中一个支撑件，以将支撑脚锁定在预定角度 并且弹簧偏压保持构件以与支撑件接合。 第二实施例包括附接到支撑脚并且具有用于切削辅助件的人造激光线的可拆卸透明板