摘要:
A backpack that has an outward appearance of a stuffed character, while providing an imbedded tracker device to monitor the location of a child. The backpack includes a main compartment, adjustable straps, and one or more small compartments. The exterior surface of the main compartment is adapted to repel water and illuminate in low light environments. The interior surface of the main compartment includes an insulated lining with pockets. The upper end of the main compartment includes a Global Positioning System (GPS) tracking unit therein. The GPS tracking unit is adapted to communicate with a server and a GPS satellite to disclose the location of a child that is carrying the backpack. The small compartments are adapted to store emergency supplies such as a first aid kit and an emergency contact card. In this way, the present invention facilitates parents and guardians in supervision and monitoring of a child.
摘要:
A preferred embodiment of the present invention comprises a foot assembly for a power hand tool such as a jigsaw that has an angularly adjustable support foot with a generally flat bottom, at least two spaced apart supports connected to the support foot, an elongated rod extends through apertures in the supports in a configuration that permits limited sliding movement and the angular adjusting movement of the support foot relative to the hand tool, a retainer member associated with the hand tool that selectively engages one of the supports to lock the support foot at predetermined angular positions, and a spring biases the retainer member toward engagement with the support. A second embodiment includes a removable transparent plate that attaches to the support foot and has a faux laser line for a cutting aid.
摘要:
The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
摘要翻译:本发明提供式(I)化合物及其药学上可接受的盐,其中R 1,R 2,R 3,R 3, R 4,R 5,R 6,m和n如本文所述定义。 本发明还提供了在哺乳动物中制备式(I)化合物的方法和治疗炎性疾病如类风湿性关节炎的方法,包括向哺乳动物施用治疗有效量的式(I)化合物。
摘要:
This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.
摘要:
Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
摘要:
Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.
摘要:
A portable filtered drinking water system for removing undesirable tastes, odors, and contaminants from potable water to improve the quality of the water for drinking or consumption. The device consists of a container that holds the potable water and has an air tight screw on cap. Mounted on the cap is an opening for a screw-in hand air pump to create air pressure inside the container and an opening for a faucet for dispensing filtered drinking water. Pulling up and pushing down several times on the hand air pump creates air pressure in the container that forces the potable water through a water filter located inside the container and up to a faucet to be dispensed when a lever is pushed down.
摘要:
The present invention relates to pyrazolo[1,5-a]pyrimidine derivatives, compositions comprising an effective amount of a pyrazolo[1,5-a]pyrimidine derivative and methods for treating or preventing cancer, comprising administering to a subject in need thereof an effective amount of a pyrazolo[1,5-a]pyrimidine derivative.
摘要:
A side handle for a hand tool having a foot structure includes a support structure having a base end portion and an outer end portion, an adjustable gripable member extending from the outer end portion, and means for removably securing the support structure to the foot structure of the hand tool.