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公开(公告)号：US08134007B2
公开(公告)日：2012-03-13
申请号：US12114258
申请日：2008-05-02
申请人： Sharanjeet Kaur Bagal , Karl Richard Gibson , Mark Ian Kemp , Cedric Poinsard , Blanda Luzia Stammen , Stephen Martin Denton , Melanie Susanne Glossop
发明人： Sharanjeet Kaur Bagal , Karl Richard Gibson , Mark Ian Kemp , Cedric Poinsard , Blanda Luzia Stammen , Stephen Martin Denton , Melanie Susanne Glossop
IPC分类号： C07D413/12 , C07D413/14 , C07D401/12 , C07D401/14 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4439
CPC分类号： C07D401/12 , C07D213/75 , C07D413/12
摘要： The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，用于制备用于制备中间体的方法和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途。
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公开(公告)号：US06794387B2
公开(公告)日：2004-09-21
申请号：US10099264
申请日：2002-03-14
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： Compounds of general formula (I): wherein R1, R2, R3, R4, X, Y and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.
摘要翻译： 通式（I）的化合物：其中R 1，R 2，R 3，R 4，X，Y和A具有本文给出的用于治疗和预防性治疗 需要抑制环鸟苷3'，5'-单磷酸磷酸二酯酶（如cGMP PDE5）的医疗条件。
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公开(公告)号：US06372736B1
公开(公告)日：2002-04-16
申请号：US09358107
申请日：1999-07-21
IPC分类号： A01N4346
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds of the formula (I): wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage.
摘要翻译： 式（I）化合物：其中A，Y，R，X，R 1，R 2，R 3和R 4如上定义，是旋转异构酶特别是FKBP-12和FKBP-52的抑制剂。 因此，所述化合物适度地进行神经元再生和生长，并可用于治疗由神经变性疾病或涉及神经损伤的其它疾病引起的神经障碍。
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公开(公告)号：US20100227872A1
公开(公告)日：2010-09-09
申请号：US12598308
申请日：2008-04-21
申请人： Mark Ian Kemp
发明人： Mark Ian Kemp
IPC分类号： A61K31/497 , C07D413/12 , C07D403/12 , A61P29/00
CPC分类号： C07D413/12 , C07D403/12
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐和溶剂化物，其制备方法，用于制备的中间体和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途。
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公开(公告)号：US07572797B2
公开(公告)日：2009-08-11
申请号：US11556354
申请日：2006-11-03
申请人： Stephen Mark Denton , Karl Richard Gibson , Melanie Susanne Glossop , Mark Ian Kemp , Cedric Poinsard
发明人： Stephen Mark Denton , Karl Richard Gibson , Melanie Susanne Glossop , Mark Ian Kemp , Cedric Poinsard
IPC分类号： A61K31/497
CPC分类号： C07D403/12 , C07D413/12
摘要： The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐和溶剂化物，其制备方法，用于制备的中间体和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途。
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公开(公告)号：US20090048306A1
公开(公告)日：2009-02-19
申请号：US12114258
申请日：2008-05-02
申请人： Sharanjeet Kaur Bagal , Karl Richard Gibson , Mark Ian Kemp , Cedric Poinsard , Blanda Luzia Christa Stammen , Stephen Martin Denton , Melanie Susanne Glossop
发明人： Sharanjeet Kaur Bagal , Karl Richard Gibson , Mark Ian Kemp , Cedric Poinsard , Blanda Luzia Christa Stammen , Stephen Martin Denton , Melanie Susanne Glossop
IPC分类号： A61K31/4439 , C07D401/12 , A61P25/04
CPC分类号： C07D401/12 , C07D213/75 , C07D413/12
摘要： The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，用于制备用于制备中间体的方法和含有这些化合物的组合物以及这些化合物用于治疗疼痛的用途。
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7.发明授权3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands 有权3-或4-单取代苯酚和可用作H3配体的苯硫酚衍生物公开(公告)号：US07456164B2
公开(公告)日：2008-11-25
申请号：US11124876
申请日：2005-05-09
申请人： Patrick Bernardelli , Andrew Michael Cronin , Alexis Denis , Stephen Martin Denton , Henry Jacobelli , Mark Ian Kemp , Edwige Lorthiois , Fiona Rousseau , Delphine Serradeil-Civit , Fabrice Vergne
发明人： Patrick Bernardelli , Andrew Michael Cronin , Alexis Denis , Stephen Martin Denton , Henry Jacobelli , Mark Ian Kemp , Edwige Lorthiois , Fiona Rousseau , Delphine Serradeil-Civit , Fabrice Vergne
IPC分类号： A61K31/397 , A61K31/4025 , A61K31/4427 , A61K31/4439 , A61K31/443 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , C07D205/04 , C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
CPC分类号： C07D405/12 , C07D207/12 , C07D295/088 , C07D309/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said 3- or 4-monosubstituted phenol and thiophenol derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（I）的3-或4-单取代的苯酚和苯硫酚衍生物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 所述3-或4-单取代的苯酚和苯硫酚衍生物是H 3配体，并且可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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公开(公告)号：US06770645B2
公开(公告)日：2004-08-03
申请号：US10096190
申请日：2002-03-12
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： Compound of general formula I: wherein R1, R2, R3, R4, X, Y and R5 have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.
摘要翻译： 通式I的化合物：其中R 1，R 2，R 3，R 4，X，Y和R 5具有本文给出的用于治疗和预防性治疗 需要抑制环鸟嘌呤3'，5'-单磷酸磷酸二酯酶（例如cGMP PDE5）的医疗条件。
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公开(公告)号：US06784185B2
公开(公告)日：2004-08-31
申请号：US10098900
申请日：2002-03-14
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： Compounds of general formula I: or pharmaceutically or veterinarily acceptable salts, solvates, polymorphs or pro-drugs thereof wherein: wherein R1, R2, R3, R4, X and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.
摘要翻译： 通式I的化合物：或其药学或兽医学上可接受的盐，溶剂化物，多晶型物或其前体药物，其中：其中R 1，R 2，R 3，R 4，X和A具有 可用于治疗性和预防性治疗期望抑制环鸟嘌呤3'，5'-单磷酸磷酸二酯酶（例如cGMP PDE5）的医学病症。
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公开(公告)号：US06562964B1
公开(公告)日：2003-05-13
申请号：US10056901
申请日：2002-01-23
IPC分类号： C07D40300
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds of the formula (I): wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage.
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