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    Compounds Useful In Therapy
    5.
    发明申请
    Compounds Useful In Therapy 审中-公开
    化合物可用于治疗

    公开(公告)号：US20080096950A1

    公开(公告)日：2008-04-24

    申请号：US11866565

    申请日：2007-10-03

    申请人： Karl Richard Gibson ,  Sarah Elizabeth Skerratt ,  Kevin Neil Dack

    发明人： Karl Richard Gibson ,  Sarah Elizabeth Skerratt ,  Kevin Neil Dack

    IPC分类号： A61K31/4155 ,  A61P43/00 ,  C07D231/18

    CPC分类号： C07D405/04 ,  C07D409/04

    摘要： Compounds of Formula (I): and pharmaceutically acceptable salts, solvates (including hydrates) of said compounds and salts, or prodrugs of said compound, or pharmaceutically acceptable salts or solvates of said prodrugs, wherein the substituents are as herein defined, are useful in therapy, for example they may be useful for treating progesterone-mediated conditions such as endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.

    摘要翻译： 式（I）化合物及其药学上可接受的盐，所述化合物和盐的溶剂合物（包括水合物）或所述化合物的前药或所述前体药物的药学上可接受的盐或溶剂合物，其中取代基如本文所定义，可用于 治疗，例如它们可用于治疗孕激素介导的病症如子宫内膜异位症，子宫肌瘤（平滑肌瘤），月经过多，子宫腺肌症，原发性和继发性痛经（包括性交疼痛症状，经济症状和慢性盆腔疼痛）或慢性盆腔疼痛综合征 。

    Amide compounds useful in therapy
    9.
    发明授权
    Amide compounds useful in therapy 失效
    酰胺化合物可用于治疗

    公开(公告)号：US08232269B2

    公开(公告)日：2012-07-31

    申请号：US12561398

    申请日：2009-09-17

    申请人： Karl Richard Gibson ,  Martin Peter Green ,  Toby James Underwood ,  Florian Wakenhut

    发明人： Karl Richard Gibson ,  Martin Peter Green ,  Toby James Underwood ,  Florian Wakenhut

    IPC分类号： A61K31/397 ,  A61K31/415 ,  A61K31/506 ,  A61K31/4184 ,  A61K31/454 ,  C07D231/20 ,  C07D205/04 ,  C07D403/12 ,  C07D235/02 ,  C07D401/12

    CPC分类号： C07D231/14 ,  C07D231/16 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D487/04

    摘要： A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein, R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy; R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from Ra) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C1-4 alkyl); R4 represents H or C1-3 alkyl; R5 represents C1-6 alkyl (optionally substituted by one or more substituents each independently selected from Rb), C3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het2 (optionally substituted by one or more substituents each independently selected from Rd); oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C1-4 alkyl); and R6 represents C1-3 alkyl (optionally substituted by one or more substituents each independently selected from Rf), C3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen; where Rf represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids.

    摘要翻译： 式（I）的化合物或其药学上可接受的盐或溶剂合物，其中R 1和R 2各自独立地表示H，卤素，CF 3，C 1-3烷基或C 1-3烷氧基; R 3表示C 1-6烷基，C 3-6环烷基，苯基（任选被一个或多个各自独立地选自Ra的取代基）或Het（任选被一个或多个各自独立地选自OH，氧代或C 1-4烷基的取代基取代） ）; R 4表示H或C 1-3烷基; R 5表示C 1-6烷基（任选被一个或多个独立地选自Rb的取代基取代），C 3-6环烷基（任选地被一个或多个独立地选自氧代或OH的取代基取代）或Het2（任选被一个或多个 更多取代基，各自独立地选自Rd）; 氧原子或1个硫原子，或（c）1个氧原子或1个硫原子（任选被一个或多个独立地选自OH，氧代或C 1-4烷基的取代基取代）; 和R 6表示C 1-3烷基（任选被一个或多个独立地选自Rf的取代基取代），C3-5环烷基（任选被一个或多个卤素取代），CN或卤素; 其中R f表示卤素或苯基;和组合物，制备方法及其用途，例如， 治疗子宫内膜异位症或子宫肌瘤。

    Amide Compounds Useful in Therapy
    10.
    发明申请
    Amide Compounds Useful in Therapy 失效
    酰胺化合物可用于治疗

    公开(公告)号：US20100249091A1

    公开(公告)日：2010-09-30

    申请号：US12561398

    申请日：2009-09-17

    申请人： Karl Richard Gibson ,  Martin Peter Green ,  Toby James Underwood ,  Florian Wakenhut

    发明人： Karl Richard Gibson ,  Martin Peter Green ,  Toby James Underwood ,  Florian Wakenhut

    IPC分类号： A61K31/397 ,  C07D231/20 ,  A61K31/415 ,  C07D205/04 ,  C07D403/12 ,  A61K31/506 ,  C07D235/02 ,  A61K31/4184 ,  C07D401/12 ,  A61K31/454 ,  A61P35/00 ,  A61P29/00

    CPC分类号： C07D231/14 ,  C07D231/16 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D487/04

    摘要： A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein, R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy; R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from Ra) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C1-4 alkyl); R4 represents H or C1-3 alkyl; R5 represents C1-6 alkyl (optionally substituted by one or more substituents each independently selected from Rb), C3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het2 (optionally substituted by one or more substituents each independently selected from Rd); oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C1-4 alkyl); and R6 represents C1-3 alkyl (optionally substituted by one or more substituents each independently selected from Rf), C3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen; where Rf represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids

    摘要翻译： 式（I）的化合物或其药学上可接受的盐或溶剂合物，其中R 1和R 2各自独立地表示H，卤素，CF 3，C 1-3烷基或C 1-3烷氧基; R 3表示C 1-6烷基，C 3-6环烷基，苯基（任选被一个或多个各自独立地选自Ra的取代基）或Het（任选被一个或多个各自独立地选自OH，氧代或C 1-4烷基的取代基取代） ）; R 4表示H或C 1-3烷基; R 5表示C 1-6烷基（任选被一个或多个独立地选自Rb的取代基取代），C 3-6环烷基（任选地被一个或多个独立地选自氧代或OH的取代基取代）或Het2（任选被一个或多个 更多取代基，各自独立地选自Rd）; 氧原子或1个硫原子，或（c）1个氧原子或1个硫原子（任选被一个或多个独立地选自OH，氧代或C 1-4烷基的取代基取代）; 和R 6表示C 1-3烷基（任选被一个或多个独立地选自Rf的取代基取代），C3-5环烷基（任选被一个或多个卤素取代），CN或卤素; 其中R f表示卤素或苯基;和组合物，制备方法及其用途，例如， 治疗子宫内膜异位症或子宫肌瘤