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公开(公告)号:US20070015823A1
公开(公告)日:2007-01-18
申请号:US11305802
申请日:2005-12-16
申请人: Zong-Qiang Tian , David Myles , Zhan Wang , Yuan Xu , Bryan Julien , Eduardo Rodriguez , Mark Shimazu , Greg Buchanan , Leonard Katz
发明人: Zong-Qiang Tian , David Myles , Zhan Wang , Yuan Xu , Bryan Julien , Eduardo Rodriguez , Mark Shimazu , Greg Buchanan , Leonard Katz
IPC分类号: A61K31/35 , C07D405/14 , C07D405/02
CPC分类号: C07D309/14 , C07D309/22 , C07D405/06 , C07D405/12 , C07D407/08 , C07D407/12 , C07D417/12
摘要: Antifungal compounds represented by formula I where R1, R2, R3 and R4 are as defined herein. Isolated or purified naturally occurring 20,21-dihydro ambruticin compounds. The invention also provides Sorangium cellulosum ambM, ambO, ambP, and ambS mutant strains; a recombinant Sorangium cellulosum strain that produces 24-norambruticin compounds; and a method for treating a fungal infection using a compound of this invention.
摘要翻译: 由式I表示的抗真菌化合物,其中R 1,R 2,R 3和R 4如本文所定义 。 分离或纯化的天然存在的20,21-二氢氨苄青霉素化合物。 本发明还提供了丝胶纤维素ambM,ambO,ambP和ambS突变株; 产生24-诺布曲菌素化合物的重组Sorangium cellulosum菌株; 以及使用本发明化合物治疗真菌感染的方法。