公开(公告)号：US20220213222A1

公开(公告)日：2022-07-07

申请号：US17701626

申请日：2022-03-22

申请人： Kai Yuan Xu

发明人： Kai Yuan Xu

IPC分类号： C07K16/40 ,  A61K39/00 ,  A61P3/10

摘要： Methods of preventing and treating type-1 diabetes and its complications using peptide vaccines to generate endogenous specific antibody activators that bind to the (Na++K+)-ATPase.

公开(公告)号：US20190263933A1

公开(公告)日：2019-08-29

申请号：US16409841

申请日：2019-05-12

申请人： Kai Yuan Xu

发明人： Kai Yuan Xu

IPC分类号： C07K16/40 ,  A61K39/00 ,  A61P7/02

摘要： Methods of inhibiting platelet activation and aggregation using antibodies or peptide vaccines having binding specificity for the a subunit of the (Na++K+)-ATPase are provided, along with methods for inhibiting or preventing or treating thrombosis in a subject using such antibodies.

公开(公告)号：US10053505B2

公开(公告)日：2018-08-21

申请号：US15697884

申请日：2017-09-07

申请人： Kai Yuan Xu

发明人： Kai Yuan Xu

IPC分类号： C07K16/18 ,  C07K16/40 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/75

摘要： Antibodies that are agonists of sodium pump (Na+/K+ ATPase; NKA) activity are provided. In particular, antibodies that specifically bind epitopes on the beta-1(β1) subunit of NKA are disclosed. These antibodies have the ability to increase the activity of the catalytic alpha subunit of NKA upon β1 subunit binding. Due to their activity, the antibodies also have the ability to trigger a positive inotropic effect in cardiac tissues (i.e., increase cardiac contraction). The present invention thus includes, but is not limited to, NKA β1 subunit peptide epitopes, antibodies that specifically bind the epitopes, methods of increasing NKA activity and cardiac contraction through administration of the peptide vaccines or the antibodies, and methods of treating and/or preventing heart disease through administration of the peptides or the antibodies.

公开(公告)号：US09790270B2

公开(公告)日：2017-10-17

申请号：US14960664

申请日：2015-12-07

申请人： Kai Yuan Xu

发明人： Kai Yuan Xu

IPC分类号： C07K16/18 ,  C07K16/40 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/75

摘要： Antibodies that are agonists of sodium pump (Na+/K+ ATPase; NKA) activity are provided. In particular, antibodies that specifically bind epitopes on the beta-1 (β1) subunit of NKA are disclosed. These antibodies have the ability to increase the activity of the catalytic alpha subunit of NKA upon β1 subunit binding. Due to their activity, the antibodies also have the ability to trigger a positive inotropic effect in cardiac tissues (i.e., increase cardiac contraction). The present invention thus includes, but is not limited to, NKA β1 subunit peptide epitopes, antibodies that specifically bind the epitopes, methods of agonizing NKA activity through administration of the peptides or the antibodies, and methods of treating and/or preventing heart disease through administration of the peptides or the antibodies.

公开(公告)号：US09279020B2

公开(公告)日：2016-03-08

申请号：US14574310

申请日：2014-12-17

申请人： Kai Yuan Xu

发明人： Kai Yuan Xu

IPC分类号： A61K39/395 ,  C07K16/40

CPC分类号： A61K39/0005 ,  A61K48/00 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/75

摘要： Antibodies binding to sites on the alpha-subunit of the (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the alpha-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.

公开(公告)号：US08946835B2

公开(公告)日：2015-02-03

申请号：US13618691

申请日：2012-09-14

申请人： Yuan Xu ,  Wei Hu ,  Justin Jia-Jen Hwu ,  Gene Gauzner ,  Koichi Wago ,  David Shiao-Min Kuo

发明人： Yuan Xu ,  Wei Hu ,  Justin Jia-Jen Hwu ,  Gene Gauzner ,  Koichi Wago ,  David Shiao-Min Kuo

IPC分类号： H01L29/82

CPC分类号： G11B5/743 ,  B44D3/18

摘要： A planarization process may planarize a media disk that has data trenches between data features and larger servo trenches between servo features. A filler material layer is deposited on the media disk and provides step coverage of the trenches. The filler material has data recesses over the data trenches and servo recesses over the servo trenches that must be removed to produce a planar media surface. A first planarization process is used to remove the data recesses and a second planarization process is used to remove the servo recesses.

摘要翻译： 平坦化处理可以平坦化在伺服特征之间具有数据特征和较大伺服沟槽之间的数据沟槽的介质盘。 填充材料层沉积在介质盘上并提供沟槽的台阶覆盖。 填充材料在伺服沟槽上的数据沟槽和伺服凹槽上具有必须被移除以产生平面介质表面的数据凹槽。 使用第一平面化处理来去除数据凹槽，并且使用第二平面化处理来去除伺服凹部。

公开(公告)号：US20140221609A1

公开(公告)日：2014-08-07

申请号：US13886482

申请日：2013-05-03

申请人： Kai Yuan Xu

发明人： Kai Yuan Xu

IPC分类号： C07K7/08

CPC分类号： C07K7/08 ,  A61K39/00 ,  A61K39/0005 ,  A61K2039/505 ,  C07K7/02 ,  C07K7/04 ,  C07K7/50 ,  C07K7/64 ,  C07K16/40 ,  C07K2317/75 ,  C12N9/14 ,  G01N2333/914 ,  G01N2500/04 ,  G01N2800/325

摘要： Activation sites on the alpha subunit of sodium potassium ATPase have been discovered. It has also been discovered that certain antibodies that bind to the alpha subunit of sodium potassium ATPase dramatically increase enzyme activity. There has never before been a report of precise activation sites or drug interaction sites for sodium potassium ATPase. Certain methods have also been discovered for treating or preventing diseases associated with low sodium potassium ATPase activity by administering antibodies, antibody fragments and small molecules that bind to the activation sites on the alpha subunit of sodium potassium ATPase.

摘要翻译： 已经发现钠钾ATP酶的α亚基上的活化位点。 还已经发现，结合钠钾ATP酶的α亚基的某些抗体显着增加酶活性。 以前从未有过关于钠钾ATP酶的精确活化位点或药物相互作用位点的报告。 还已经发现某些方法用于治疗或预防与低钾钾ATP酶活性相关的疾病，通过施用结合于钠钾ATP酶的α亚基上的活化位点的抗体，抗体片段和小分子。

公开(公告)号：US20140049746A1

公开(公告)日：2014-02-20

申请号：US13983307

申请日：2012-02-23

申请人： Yuwen Liu ,  Junhao Ge ,  Charlie Chen ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Charles A. Francis

发明人： Yuwen Liu ,  Junhao Ge ,  Charlie Chen ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Charles A. Francis

IPC分类号： G02B1/04

CPC分类号： G02B1/043 ,  B29D11/00125 ,  C08L83/12 ,  G02C7/04 ,  G02C7/049 ,  C08L101/14 ,  C08L83/04

摘要： Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent. The contact lenses have ophthalmically-acceptable ionoflux values and surface wettability, and can be manufactured without the use of volatile organic solvents.

摘要翻译： 硅氧烷水凝胶隐形眼镜由包含至少一种含丙烯酸酯的硅氧烷单体，至少一种亲水性含乙烯基单体和至少一种含乙烯基交联剂的可聚合组合物的反应产物形成。 隐形眼镜具有眼睛可接受的离子通量值和表面润湿性，并且可以在不使用挥发性有机溶剂的情况下制造。

公开(公告)号：US20120259574A1

公开(公告)日：2012-10-11

申请号：US13080474

申请日：2011-04-05

申请人： Chenmin Hu ,  Bo Su ,  Ping Zhang ,  Yuan Xu ,  Qing Zhang

发明人： Chenmin Hu ,  Bo Su ,  Ping Zhang ,  Yuan Xu ,  Qing Zhang

IPC分类号： G06F19/00

CPC分类号： H01L22/20 ,  H01L2924/0002 ,  H01L2924/00

摘要： An integrated-circuit yield improvement system includes a global signature analysis/grouping module configured to receive an integrated circuit (IC) design and identify areas in the IC design that include potential defect signatures based on the defect signatures stored in the defect signature library. The global signature analysis/grouping module can produce a global signature map indicating these areas and their associated potential defect signatures in the IC design. A local signature analysis/grouping module can identify and group local defect signatures in the IC design with the process monitoring and yield data as input, to output grouped local signatures. An intelligent learning engine can analyze the global signature map and the grouped local signatures and update some of the defect signatures in the defect signature library. A feedback loop is formed to update and renew the contents of the defect signature library for each new IC design while process and yield are improved.

摘要翻译： 集成电路产量改进系统包括全局签名分析/分组模块，其被配置为接收集成电路（IC）设计，并基于存储在缺陷签名库中的缺陷签名来识别IC设计中包括潜在缺陷签名的区域。 全局签名分析/分组模块可以产生一个全局签名图，指示这些区域及其相关的潜在缺陷签名在IC设计中。 本地签名分析/分组模块可以通过流程监控和收益数据作为输入来识别和分组IC设计中的本地缺陷签名，以输出分组的本地签名。 智能学习引擎可以分析全局签名图和分组的本地签名，并更新缺陷签名库中的一些缺陷签名。 形成反馈循环，以更新和更新每个新IC设计的缺陷签名库的内容，同时改进处理和产量。

公开(公告)号：US20120220744A1

公开(公告)日：2012-08-30

申请号：US13404037

申请日：2012-02-24

申请人： Yuwen Liu ,  Charlie Chen ,  Charles A. Francis ,  Junhao Ge ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ying Zheng

发明人： Yuwen Liu ,  Charlie Chen ,  Charles A. Francis ,  Junhao Ge ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ying Zheng

IPC分类号： C08F230/08

CPC分类号： G02C7/04 ,  B65B5/04 ,  G02B1/043 ,  C08L83/12 ,  C08L33/08 ,  C08L33/10

摘要： Ophthalmically acceptably wettable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer. The lenses have ophthalmically acceptably wettable lens surfaces when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了眼科可接受的可湿性硅氧水凝胶隐形眼镜。 透镜衍生自包含第一硅氧烷单体的可聚合组合物。 当完全水合时，镜片具有眼科可接受的可润湿透镜表面。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。