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公开(公告)号:US07259156B2
公开(公告)日:2007-08-21
申请号:US11133880
申请日:2005-05-17
申请人: Daniel V. Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
发明人: Daniel V. Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
IPC分类号: C07D225/06 , A61K31/395
CPC分类号: A61K31/33 , A61K31/675 , A61K31/7052 , C07D225/00
摘要: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
摘要翻译: 具有式I的结构的格尔德霉素化合物,其中Q 1,L 1,L 1,R 5,R 6, >和R 11如本文所定义,可用于治疗通过抑制细胞外热休克蛋白-90的功能而改善的疾病或病症。
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公开(公告)号:US20050267046A1
公开(公告)日:2005-12-01
申请号:US11133880
申请日:2005-05-17
申请人: Daniel Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
发明人: Daniel Santi , Zong-Qiang Tian , Yaoquan Liu , Zhan Wang
IPC分类号: A61K31/33 , A61K31/675 , A61K31/7052
CPC分类号: A61K31/33 , A61K31/675 , A61K31/7052 , C07D225/00
摘要: Geldanamycin compounds having a structure according to formula I where Q1, L, L1, R5, R6, and R11 are as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.
摘要翻译: 具有式I的结构的格尔德霉素化合物,其中Q 1,L 1,L 1,R 5,R 6, >和R 11如本文所定义,可用于治疗通过抑制细胞外热休克蛋白-90的功能而改善的疾病或病症。
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公开(公告)号:US06875863B1
公开(公告)日:2005-04-05
申请号:US10826447
申请日:2004-04-16
申请人: Zong-Qiang Tian , Yaoquan Liu , David C. Myles , Zhan Wang
发明人: Zong-Qiang Tian , Yaoquan Liu , David C. Myles , Zhan Wang
IPC分类号: C07D207/46 , C07D225/04 , C07D225/06 , C07D403/12
CPC分类号: C07D207/46 , C07D403/12
摘要: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
摘要翻译: 在基团R 1和R 4中具有式I结构的化合物如说明书中所定义,可用作抗增殖剂。
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公开(公告)号:US20070015823A1
公开(公告)日:2007-01-18
申请号:US11305802
申请日:2005-12-16
申请人: Zong-Qiang Tian , David Myles , Zhan Wang , Yuan Xu , Bryan Julien , Eduardo Rodriguez , Mark Shimazu , Greg Buchanan , Leonard Katz
发明人: Zong-Qiang Tian , David Myles , Zhan Wang , Yuan Xu , Bryan Julien , Eduardo Rodriguez , Mark Shimazu , Greg Buchanan , Leonard Katz
IPC分类号: A61K31/35 , C07D405/14 , C07D405/02
CPC分类号: C07D309/14 , C07D309/22 , C07D405/06 , C07D405/12 , C07D407/08 , C07D407/12 , C07D417/12
摘要: Antifungal compounds represented by formula I where R1, R2, R3 and R4 are as defined herein. Isolated or purified naturally occurring 20,21-dihydro ambruticin compounds. The invention also provides Sorangium cellulosum ambM, ambO, ambP, and ambS mutant strains; a recombinant Sorangium cellulosum strain that produces 24-norambruticin compounds; and a method for treating a fungal infection using a compound of this invention.
摘要翻译: 由式I表示的抗真菌化合物,其中R 1,R 2,R 3和R 4如本文所定义 。 分离或纯化的天然存在的20,21-二氢氨苄青霉素化合物。 本发明还提供了丝胶纤维素ambM,ambO,ambP和ambS突变株; 产生24-诺布曲菌素化合物的重组Sorangium cellulosum菌株; 以及使用本发明化合物治疗真菌感染的方法。
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公开(公告)号:US06506733B1
公开(公告)日:2003-01-14
申请号:US09526300
申请日:2000-03-15
IPC分类号: A61K3805
CPC分类号: C07C271/22 , C07C235/78 , C07C275/24 , C07C317/28
摘要: Compounds of the formula: are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins K or S contribute to the pathology or symptomatolgy of the disease.
摘要翻译: 具有下式的化合物,并且可用作半胱氨酸蛋白酶抑制剂,特别是用于治疗组织蛋白酶K或S对组织蛋白酶K或S有助于疾病的病理学或症状性疾病的疾病如骨质疏松症或自身免疫性疾病。
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公开(公告)号:US06476026B1
公开(公告)日:2002-11-05
申请号:US09526485
申请日:2000-03-15
申请人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
发明人: Clifford M. Bryant , James T. Palmer , Robert M. Rydzewski , Eduardo L. Setti , Zong-Qiang Tian , Shankar Venkatraman , Dan-Xiong Wang
IPC分类号: A61K314439
CPC分类号: C07D213/70 , C07B2200/07 , C07C255/24 , C07C255/29 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/06 , C07C311/09 , C07C317/50 , C07C323/60 , C07C323/62 , C07C2601/14 , C07D207/16 , C07D209/06 , C07D209/26 , C07D209/52 , C07D211/60 , C07D213/81 , C07D213/82 , C07D233/26 , C07D239/28 , C07D277/30 , C07D277/42 , C07D277/56 , C07D295/155 , C07D295/215 , C07D307/68 , C07D333/20 , C07D333/38 , C07D417/04 , C07D417/12
摘要: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
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公开(公告)号:US07241754B2
公开(公告)日:2007-07-10
申请号:US10868724
申请日:2004-06-14
申请人: Zong-Qiang Tian , Robert McDaniel , David C. Myles , Kedar Gautam Patel , Misty Piagentini , Zhan Wang
发明人: Zong-Qiang Tian , Robert McDaniel , David C. Myles , Kedar Gautam Patel , Misty Piagentini , Zhan Wang
IPC分类号: C07D225/04 , C07D225/06 , A61K31/395 , A61K31/33 , A61K31/40
CPC分类号: C07D225/06 , C07D491/04
摘要: 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents
摘要翻译: 具有式I结构的2-去甲基安沙霉素,其中R 1,R 2,R 3,R 4, 其中R 5,R 5和R 6如本文所定义,而其它2-去甲基安沙霉素可用作抗增殖剂
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公开(公告)号:US06887993B1
公开(公告)日:2005-05-03
申请号:US10826445
申请日:2004-04-16
申请人: Zong-Qiang Tian , Yaoquan Liu , David C. Myles , Zhan Wang
发明人: Zong-Qiang Tian , Yaoquan Liu , David C. Myles , Zhan Wang
IPC分类号: C07D225/06 , C07D225/04
CPC分类号: C07D225/06
摘要: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
摘要翻译: 具有式I结构的化合物,其中基团R 1和R 4如说明书中所定义,可用作抗增殖剂。
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公开(公告)号:US06870049B1
公开(公告)日:2005-03-22
申请号:US10826446
申请日:2004-04-16
申请人: Zong-Qiang Tian , Yaoquan Liu , David C. Myles , Zhan Wang
发明人: Zong-Qiang Tian , Yaoquan Liu , David C. Myles , Zhan Wang
IPC分类号: C07D225/04 , C07D225/06
CPC分类号: C07D225/06
摘要: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
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公开(公告)号:US20050026894A1
公开(公告)日:2005-02-03
申请号:US10868724
申请日:2004-06-14
申请人: Zong-Qiang Tian , Robert McDaniel , David Myles , Kedar Patel , Misty Piagentini , Zhan Wang
发明人: Zong-Qiang Tian , Robert McDaniel , David Myles , Kedar Patel , Misty Piagentini , Zhan Wang
IPC分类号: A61K20060101 , A61K31/33 , A61P35/00 , C07D507/00 , C12N1/21
CPC分类号: C07D225/06 , C07D491/04
摘要: 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents.
摘要翻译: 具有式I结构的2-去甲基安沙霉素,其中R 1,R 2,R 3,R 4,R 5和R 6如本文所定义,其它2 β-甲基安沙霉素可用作抗增殖剂。
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